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Basic research for the development of urinary stone fragmentation therapy in the space environment

Research Project

Project/Area Number 18K16741
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56030:Urology-related
Research InstitutionNagoya City University

Principal Investigator

Banno Rika  名古屋市立大学, 医薬学総合研究院(医学), 研究員 (20600753)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords尿路結石 / ESWL / 宇宙空間 / オシロスコープ / ハイドロフォン / モデル結石 / 体外衝撃波結石破砕 / 宇宙飛行 / 体外衝撃波結石破砕術
Outline of Final Research Achievements

In the space environment, increased excretion of urinary calcium induces the risk of urinary stone formation by increased bone resorption. However, no surgical treatment for urinary stones in the space has been investigated so far. The purpose of this study is to investigate whether the extracorporeal shock wave lithotripsy (ESWL) can be applied as urinary stone surgery in the space.
We started verification using a shock wave device for the treatment of aponeurositis for the development of a small ESWL, but the lack of shock wave convergence capability of this model and the spread of the new coronavirus infection made it difficult to jointly develop the device internationally. Therefore, we constructed a fragmentation simulation using ESWL equipment for real patient treatment and established an environment for shock wave intensity measurement using a hydrophone.

Academic Significance and Societal Importance of the Research Achievements

宇宙空間での尿路結石形成リスクとその予防法について、これまで私たちはJAXA/NASAとの共同研究によって一定の成果を得てきた。しかし、今後長期間の宇宙飛行や宇宙移住を想定とした予防法については確立できていない。このため、将来想定される地球外での尿路結石の発症に対し、外科的治療を確立することが必要だという着想に至った。
衝撃波強度の測定環境の構築は、宇宙空間での研究に応用可能となる。また宇宙飛行船・国際宇宙ステーションに搭載可能な小型ESWL機器の開発の成功は、将来の宇宙飛行士の健康に寄与するだけではなく、地上での新しい尿路結石治療法の確立にも貢献するという社会的意義がある。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (13 results)

All 2020 2019

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Complete response of renal cell carcinoma with an inferior vena cava tumor thrombus and lung metastases after treatment with nivolumab plus ipilimumab.2020

    • Author(s)
      Okada T, Hamamoto S, Etani T, Naiki T, Sue Y, Banno R, Yamada K, Sakakura T, Yasui T.
    • Journal Title

      Int Cancer Conf J.

      Volume: 9 Issue: 2 Pages: 88-91

    • DOI

      10.1007/s13691-020-00403-9

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low Geriatric Nutritional Risk Index as a Poor Prognostic Marker for Second-Line Pembrolizumab Treatment in Patients with Metastatic Urothelial Carcinoma: A Retrospective Multicenter Analysis2020

    • Author(s)
      Etani Toshiki、Naiki Taku、Sugiyama Yosuke、Nagai Takashi、Iida Keitaro、Noda Yusuke、Shimizu Nobuhiko、Tasaki Yoshihiko、Mimura Yoshihisa、Okada Tomoki、Banno Rika、Kubota Hiroki、Hamamoto Shuzo、Ando Ryosuke、Kawai Noriyasu、Yasui Takahiro
    • Journal Title

      Oncology

      Volume: 98 Issue: 12 Pages: 876-883

    • DOI

      10.1159/000508923

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] M2 macrophages differentiated from iPS cells have higher abilities to phagocytose and process calcium oxalate crystals than similarly induced M1 macrophages2020

    • Author(s)
      Okada Atsushi, Aoki Hiromasa, Onozato Daichi, Kato Taiki, Takase Hiroshi, Ohshima Shigeru, Banno Rika, Taguchi Kazumi, Hashita Tadahiro, Matsunaga Tamihide, Kohri Kenjiro, Yasui Takahiro
    • Organizer
      American Urological Association Annual Meeting 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The impact of SWL hands-on training on maintaining high success rate and identification of performance improvement factors2020

    • Author(s)
      Okada Atsushi, Tanaka Yutaro, Sugino Teruaki, Unno Rei, Banno Rika, Hamamoto Shuzo, Ando Ryosuke, Tozawa Keiichi, Yasui Takahiro
    • Organizer
      American Urological Association Annual Meeting 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Induction of human iPS cell-derived M1 / M2 macrophages and comparison of phagocytic ability of calcium oxalate crystals by real-time imaging analysis2020

    • Author(s)
      Okada Atsushi, Aoki Hiromasa, Onozato Daichi, Kato Taiki , Takase Hiroshi, Ohshima Shigeru, Taguchi Kazumi, Rika Banno, Hashita Tadahiro, Matsunaga Tamihide , Kohri Kenjiro , Yasui Takahiro
    • Organizer
      第108回日本泌尿器科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 転移性腎細胞癌に対するニボルマブ・イピリムマブ併用療法の初期使用経験2020

    • Author(s)
      岡田 朋記、濵本 周造、惠谷 俊紀、須江 保仁、阪野 里花、山田 健司、坂倉 毅、安井 孝周
    • Organizer
      第108回日本泌尿器科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 当院における進行性尿路上皮癌に対するペムブロリズマブの初期治療経験2020

    • Author(s)
      (一般ポスター)須江 保仁、阪野 里花、山田 健司、惠谷俊紀、内木 拓、河合 憲康、坂倉 毅、安井 孝周
    • Organizer
      第108回日本泌尿器科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 精嚢癌が疑われたBurned out testicular tumorの1例2019

    • Author(s)
      岡田 朋記、阪野 里花、山田 健司、坂倉 毅
    • Organizer
      第280回日本泌尿器科学会東海地方会
    • Related Report
      2019 Research-status Report
  • [Presentation] 腎盂腎炎治療後に実施したTULの検討2019

    • Author(s)
      岡田 朋記、田口 和己、濵本 周造、岡田 淳志、阪野 里花、山田 健司、坂倉 毅、安井 孝周
    • Organizer
      第107回日本泌尿器科学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] ニボルマブ・イピリムマブ併用療法によってCRを得た下大静脈腫瘍塞栓を伴う左腎細胞癌の1例2019

    • Author(s)
      岡田 朋記、須江 保仁、阪野 里花、山田 健司、坂倉 毅、安井 孝周、須田 久雄
    • Organizer
      第281回日本泌尿器科学会東海地方会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 行性尿路上皮癌に対するペムブロリズマブ投与の初期経験2019

    • Author(s)
      惠谷 俊紀、内木 拓、野田 祐介、飯田 啓太郎、永井 隆、野崎 哲史、阪野 里花、安藤 亮介、池上 要介、窪田 裕樹、橋本 良博、河合 憲康、安井 孝周
    • Organizer
      第57回日本癌治療学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 当院におけるニボルマブ・イピリムマブ併用療法の初期使用経験2019

    • Author(s)
      岡田 朋記、須江 保仁、阪野 里花、山田 健司、坂倉 毅、安井 孝周
    • Organizer
      第69回日本泌尿器科学会中部総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 虫垂癌による膀胱浸潤を来した1例2019

    • Author(s)
      須江 保仁、阪野 里花、山田 健司、坂倉 毅
    • Organizer
      第282回日本泌尿器科学会東海地方会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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