Circulatory dynamics and metabolic mechanism among pregnant women who have higher risks of cardiovascular disease
Project/Area Number |
18K16753
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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Research Institution | Hirosaki University |
Principal Investigator |
Iino Kaori 弘前大学, 医学部附属病院, 客員研究員 (40568896)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2020: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
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Keywords | 妊娠高血圧症候群 / 周産期合併症 / 心血管疾患 / 高血圧症 / 脂質異常症 |
Outline of Final Research Achievements |
We aimed to determine if change in blood pressure during pregnancy is related to the average blood pressure during pregnancy and evaluate the association between blood pressure changes during pregnancy and the development of hypertension later in life. We collected Maternity Health Record Books from 735 women who participated in the Iwaki Health Promotion Project; 520 women were included and divided them into quartiles (Q1-Q4) according to their averaged systolic and diastolic blood pressures during pregnancy. The change in blood pressure for each gestational month relative to non-pregnant measurements was calculated. The rates of development of hypertension in the systolic blood pressure groups were 9.2% (Q1), 19.2% (Q2), 24.6% (Q3), and 23.8% (Q4). The rates for the diastolic blood pressure groups were 13.8% (Q1), 18.5% (Q2), 18.5% (Q3), and 26.2% (Q4). Higher averaged blood pressure during pregnancy was associated with smaller changes in blood pressure.
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Academic Significance and Societal Importance of the Research Achievements |
妊娠中の血圧値が将来の心血管疾患リスクと関連することは妊娠時の情報、特に血圧値が将来の心血管疾患発症を予測するうえで有用なマーカーであることを示唆している。 妊娠時に判明する将来の心血管疾患リスクは我々産婦人科医が把握しやすい重要な情報である。しかし、多くの場合これらの有益な情報は疾患一次予防に役立っているとはいい難く、長期的なフォロー体制を模索することが望まれる。
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Reduced serum levels of anti-Mullerian hormone is a putative biomarker of early knee osteoarthritis in middle-aged females at menopausal transition2021
Author(s)
Sasaki E, Chiba D, Ota S, Kimura Y, Sasaki S, Yamamoto Y, Oishi M, Iino K, Ando M, Tsuda E, Ishibashi Y.
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Journal Title
Scientific Reports
Volume: 11
Pages: 4931-4931
Related Report
Peer Reviewed / Open Access
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