Elucidation of pathophysiology and development of new therapeutic agents for preeclampsia through complement inhibition
| Project/Area Number |
18K16770
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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| Research Institution | Osaka University |
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Principal Investigator |
Mimura Kazuya 大阪大学, 医学系研究科, 助教 (50437422)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 妊娠高血圧症候群 / 補体 / ヒト臍帯血管内皮細胞 / 予知・予後予測マーカー / 予知 / 予後予測マーカー / 妊娠高血圧腎症 / Drug Repositioning |
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| Outline of Final Research Achievements |
We investigated whether complement activity is involved in the pathology of preeclampsia in human samples, and elucidated a new mechanism by utilizing the preeclampsia maternal vascular endothelium model using human umbilical cord vascular endothelial cells. The other purpose was to comprehensively screen new drugs that can improve vascular endothelial damage via complement inhibitory action by adding to the model. As an in vivo study, we searched for complement markers in serum and urine to determine whether complement could be a predictive and prognostic marker for preeclampsia, and investigated complement activity in preeclampsia cases. In addition, we have conducted a comprehensive screening using a library of Kampo drugs using an in vitro preeclampsia model to narrow down candidate drugs.
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| Academic Significance and Societal Importance of the Research Achievements |
妊娠高血圧症候群の中でも妊娠高血圧腎症は、妊娠20週以降に発症する高血圧、尿蛋白、他の全身障害を特徴とした疾患で、胎児死亡・母体死亡の主な原因である。全妊娠の5-8%に発症する高い頻度に加え、現在、分娩年齢の高齢化に伴い増加している。日本における妊娠高血圧症候群も最近Hypertensive Disorders of Pregnancy（HDP）と改名され、HDPはけして軽症な病態はなく、すぐに治療に取り掛かるべき疾患であるという啓発が進んでいる。いまだ治療は分娩のみで薬物療法は確立していない。母体健康・胎児健康のためにも、治療薬の開発に寄与することは現在の周産期医学において非常に重要である。
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Report
(3 results)
Research Products
(33 results)
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[Journal Article] Successful management of fetal hemolytic disease due to strong anti-Rh17 with plasma exchange and intrauterine transfusion in a woman with the D--phenotype.2020
Author(s)
Mimura K, Endo M, Takahashi A, Doi Y, Sakuragi M, Kiyokawa T, Taniguchi H, Kitabatake Y, Handa M, Tomimatsu T, Tomiyama Y, Isaka Y, Kimura T.
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Journal Title
International Journal of Hematology
Volume: 111
Issue: 1
Pages: 149-154
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A rare type of vasa previa2019
Author(s)
Hara, T. Matsuzaki, S. Kakigano, A. Mimura, K. Takiuchi, T. Kimura, T.
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Journal Title
Clinical case reports.
Volume: 7(11)
Issue: 11
Pages: 2263-2264
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Single versus multiple cervical dilation by osmotic dilator before induction of labor for second-trimester abortion2019
Author(s)
Lee, M. Mimura, K. Endoh, M. Kawanishi, Y. Miyake, T. Kakigano, A. Takiuchi, T. Matsuzaki, S. Tomimatsu, T. Kimura, T.
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Journal Title
J Obstet Gynaecol Res
Volume: 45(5)
Issue: 5
Pages: 961-966
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Obstetric outcome in patients with a unicornuate uterus after laparoscopic resection of a rudimentary horn2018
Author(s)
Sawada, M. Kakigano, A. Matsuzaki, S. Takiuchi, T. Mimura, K. Kumasawa, K. Endo, M. Ueda, Y. Yoshino, K. Kimura, T.
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Journal Title
J Obstet Gynaecol Res
Volume: -
Issue: 6
Pages: 1080-1086
DOI
Related Report
Peer Reviewed / Open Access
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[Book] 胎児発育不全2018
Author(s)
味村和哉、金山 尚裕、池田 智明 他
Total Pages
196
Publisher
中外医学社
ISBN
9784498060906
Related Report
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