| Project/Area Number |
18K16804
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | エストロゲン受容体β / 骨格筋 / 女性のヘルスケア / 糖代謝 / エストロゲン欠乏 |
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| Outline of Final Research Achievements |
Recently, sarcopenia, an age-related progressive loss of muscle mass and strength has been focused. Estrogens are important for comprehensively maintaining muscle function, and an insufficiency affects muscle strength and regeneration in females. In this study, we focused on estrogen receptor (ER)β, which is thought to be involved in skeletal muscle development and regeneration. We generated muscle-specific ERβ‐knockout (mKO) and satellite cell-specific ERβ-knockout (scKO) mice. The mKO mice showed a decrease in both muscle mass and muscle strength. The scKO mice also showed impaired muscle regeneration following acute muscle injury. ERβ plays an important role in skeletal muscle development and regeneration.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、女性特異的な骨格筋制御のメカニズムの一端を明らかにすることができた。これまでにあまり考慮されることがなかった性差に注目した骨格筋研究の重要性を指摘することができた。
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