• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Predicting and preventing the progression of naive and recurrent keratoconus

Research Project

Project/Area Number 18K16917
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionThe University of Tokyo

Principal Investigator

Junko Yoshida  東京大学, 医学部附属病院, 届出研究員 (20770465)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords円錐角膜 / 再発円錐角膜 / 進行予測因子 / 進行予防 / リスクファクター / バイオマーカ / バイオマーカー / 再発 / 進行予測
Outline of Final Research Achievements

Keratoconus is a progressive, ectatic corneal disorder which could lead to visual impairment in young generation. Serious cases eventually need to receive corneal transplants. We sometimes see patients who show recurrent keratoconus long after corneal transplants. We performed this study to reveal the characteristics and risk factors of recurrent keratoconus. As a result, we revealed that keratoconus could progress decades of years after corneal transplants and the acute hydrops could be severer than treatment naive keratoconus. The risk factor of recurrent keratoconus was a small graft size.

Academic Significance and Societal Importance of the Research Achievements

円錐角膜は、世界的にも全層角膜移植の適応疾患の上位にある疾患である。円錐角膜の術後再発については症例報告は散見されるものの、その詳細についてのまとまった報告はほとんどなかった。本研究では歴史の長い病院での研究調査ならではの貴重なデータが提供できた。また結果解釈により、手術時の移植片のサイズ決定、術後管理の面においても有用であった。円錐角膜の病因等については未解明な部分も多く、本知見をきっかけにさらなる理解、進行予防法の解明につながることが期待できる。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (50 results)

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article (19 results) (of which Peer Reviewed: 19 results,  Open Access: 7 results) Presentation (31 results) (of which Int'l Joint Research: 8 results)

  • [Journal Article] Investigation of the Sectorized Corneal Thickness of Eyes With Corneal Endothelial Dysfunction Using Anterior-Segment Optical Coherence Tomography2023

    • Author(s)
      Omoto Takashi、Kim Minjae、Goto Hiroki、Abe Yuito、Ono Takashi、Taketani Yukako、Toyono Tetsuya、Yoshida Junko、Usui Tomohiko、Yamagami Satoru、Aihara Makoto、Miyai Takashi
    • Journal Title

      Cornea

      Volume: 42 Issue: 6 Pages: 714-718

    • DOI

      10.1097/ico.0000000000003061

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative evaluation of corneal irregularity and scarring after infectious keratitis using anterior segment optical coherence tomography2023

    • Author(s)
      Ichikawa Kazunori、Ono Takashi、Chen Lily、Kitamoto Kohdai、Taketatni Yukako、Toyono Tetsuya、Yoshida Junko、Aihara Makoto、Miyai Takashi
    • Journal Title

      Graefe's Archive for Clinical and Experimental Ophthalmology

      Volume: 262 Issue: 1 Pages: 133-141

    • DOI

      10.1007/s00417-023-06157-3

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of rigid gas-permeable contact lens on keratometric indices and corneal thickness of keratoconus eyes examined with anterior segment optical coherence tomography2022

    • Author(s)
      Akiyama Kaho、Ono Takashi、Ishii Hitoha、Chen Lily Wei、Kitamoto Kohdai、Toyono Tetsuya、Yoshida Junko、Aihara Makoto、Miyai Takashi
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 7 Pages: e0270519-e0270519

    • DOI

      10.1371/journal.pone.0270519

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corneal irregularity and visual function using anterior segment optical coherence tomography in TGFBI corneal dystrophy2022

    • Author(s)
      Abe Yuito、Omoto Takashi、Kitamoto Kohdai、Toyono Tetsuya、Yoshida Junko、Asaoka Ryo、Yamagami Satoru、Miyai Takashi、Usui Tomohiko
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 13759-13759

    • DOI

      10.1038/s41598-022-17738-3

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-year results of accelerated transepithelial cross-linking (30 mW/cm2× 3 min) for keratoconus: a prospective study2022

    • Author(s)
      Ishii Hitoha、Yoshida Junko、Toyono Tetsuya、Yamagami Satoru、Usui Tomohiko、Miyai Takashi
    • Journal Title

      BMJ Open Ophthalmology

      Volume: 7 Issue: 1 Pages: e000827-e000827

    • DOI

      10.1136/bmjophth-2021-000827

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of efficacy and safety of accelerated trans-epithelial crosslinking for keratoconus patients with corneas thicker and thinner than 380μm2021

    • Author(s)
      Abe Kentaro、Miyai Takashi、Toyono Tetsuya、Aixinjueluo Wei、Inoue Tatsuya、Asano Shotaro、Ishii Hitoha、Yoshida Junko、Shirakawa Rika、Usui Tomohiko
    • Journal Title

      Current Eye Research

      Volume: Online ahead of print Issue: 4 Pages: 1-6

    • DOI

      10.1080/02713683.2021.2018466

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Descemet stripping endothelial keratoplasty after cytomegalovirus corneal endotheliitis and immunosuppression for Mooren's ulcer2021

    • Author(s)
      Ueda Koji、Ono Takashi、Toyono Tetsuya、Yoshida Junko、Kaburaki Toshikatsu、Miyai Takashi
    • Journal Title

      American Journal of Ophthalmology Case Reports

      Volume: 22 Pages: 101088-101088

    • DOI

      10.1016/j.ajoc.2021.101088

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of Long-Term Anterior and Posterior Topographic Changes in the Cornea After Ptosis Surgery Using Fourier Harmonic Analysis2021

    • Author(s)
      Yamamoto Risako、Ono Takashi、Toyono Tetsuya、Shirakawa Rika、Noda Mika、Yoshida Junko、Miyai Takashi
    • Journal Title

      Cornea

      Volume: 40 Issue: 4 Pages: 440-444

    • DOI

      10.1097/ico.0000000000002429

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 成人アトピー性皮膚炎患者の結膜に伝染性軟属腫が生じた1例2021

    • Author(s)
      鈴木 貴文 , 北本 昂大 , 吉田 絢子 , 森川 鉄平 , 豊野 哲也 , 臼井 智彦 , 宮井 尊史
    • Journal Title

      臨床眼科

      Volume: 75 Pages: 609-614

    • NAID

      40022565051

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Severe Cytomegalovirus anterior uveitis and corneal endotheliitis after use of topical tacrolimus2021

    • Author(s)
      Tsubota, Y. Fujino, Y. Ohtomo, K. Ueda, K. Yoshida, J. Miyai, T. Kaburaki, T. Mayama, C.
    • Journal Title

      International Journal of Ophthalmology

      Volume: 14 Issue: 3 Pages: 468-471

    • DOI

      10.18240/ijo.2021.03.22

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk factors and evaluation of keratoconus progression after penetrating keratoplasty with anterior segment optical coherence tomography2020

    • Author(s)
      Yoshida Junko、Toyono Tetsuya、Shirakawa Rika、Miyai Takashi、Usui Tomohiko
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 18594-18594

    • DOI

      10.1038/s41598-020-75412-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corneal topography in keratoconus evaluated more than 30?years after penetrating keratoplasty: a Fourier harmonic analysis2020

    • Author(s)
      Ono Takashi、Kawasaki Yuki、Chen Lily Wei、Toyono Tetsuya、Shirakawa Rika、Yoshida Junko、Aihara Makoto、Miyai Takashi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 14880-14880

    • DOI

      10.1038/s41598-020-71818-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of 5-Year Clinical Results of Descemet and Non-Descemet Stripping Automated Endothelial Keratoplasty.2020

    • Author(s)
      Omoto T, Toyono T, Inoue T, Shirakawa R, Yoshida J, Miyai T, Yamagami S, Usui T.
    • Journal Title

      Cornea.

      Volume: 39 Issue: 5 Pages: 573-577

    • DOI

      10.1097/ico.0000000000002211

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Severity Assessment of Acute Hydrops Due to Recurrent Keratoconus after Penetrating Keratoplasty Using Anterior Segment Optical Coherence Tomography2019

    • Author(s)
      Fujita Asahi、Yoshida Junko、Toyono Tetsuya、Usui Tomohiko、Miyai Takashi
    • Journal Title

      Current Eye Research

      Volume: 44 Issue: 11 Pages: 1189-1194

    • DOI

      10.1080/02713683.2019.1629597

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Late corneal acute hydrops in ineffective accelerated transepithelial corneal crosslinking in a patient with keratoconus2019

    • Author(s)
      Asano Shotaro、Miyai Takashi、Toyono Tetsuya、Aixinjueluo Wei、Yoshida Junko、Usui Tomohiko
    • Journal Title

      JCRS Online Case Reports

      Volume: 7 Issue: 2 Pages: 20-22

    • DOI

      10.1016/j.jcro.2018.10.001

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 緑内障術後濾過胞眼における眼瞼下垂症手術の術後経過2019

    • Author(s)
      山本 理紗子、 白川 理香、 豊野 哲也、 坂田 礼、 秋山 玲奈、 野田 実香、 吉田 絢子 宮井 尊史、 臼井 智彦、 相原 一
    • Journal Title

      日本眼科学会雑誌

      Volume: 123 Pages: 402-406

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 人工的無水晶体眼水疱性角膜症に対して角膜内皮移植術を行った3例2019

    • Author(s)
      石井 一葉、 吉田 絢子、 宮井 尊史、 臼井 智彦、 山上 聡
    • Journal Title

      眼科臨床紀要

      Volume: 12 Pages: 599-603

    • NAID

      40021993208

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics and risk factors of recurrent keratoconus over the long term after penetrating keratoplasty2018

    • Author(s)
      Yoshida Junko、Murata Hiroshi、Miyai Takashi、Shirakawa Rika、Toyono Tetsuya、Yamagami Satoru、Usui Tomohiko
    • Journal Title

      Graefe's Archive for Clinical and Experimental Ophthalmology

      Volume: 256 Issue: 12 Pages: 2377-2383

    • DOI

      10.1007/s00417-018-4131-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 全層角膜移植後円錐角膜再発により急性水腫を起こした4症例の前眼部光干渉断層計による検討2018

    • Author(s)
      藤田, あさひ 吉田, 絢子 豊野, 哲也 白川, 理香 宮井, 尊史 臼井, 智彦
    • Journal Title

      日本眼科学会雑誌

      Volume: 122 Pages: 758-765

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 教育セミナー 角膜移植の適応と基本手技、そして術後管理 全層角膜移植の基本手技2024

    • Author(s)
      吉田 絢子
    • Organizer
      第47回日本眼科手術学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Corneal Epithelium is altered in keratoconus, and forme fruste keratoconus2024

    • Author(s)
      Sukhee Nomuundari,難波 広幸,吉田 絢子,臼井 智彦
    • Organizer
      角膜カンファランス2024
    • Related Report
      2023 Annual Research Report
  • [Presentation] 円錐角膜眼におけるFloppy Eyelid症候群の特徴2024

    • Author(s)
      寺島 まり絵,難波 広幸,星 謙成,吉田 絢子,臼井 智彦
    • Organizer
      角膜カンファランス2024
    • Related Report
      2023 Annual Research Report
  • [Presentation] 顆粒状角膜変性症の視力に関連する要因2023

    • Author(s)
      阿部 結人,恒谷 美貴,橋本 友美,大本 貴士,竹渓 友香子,豊野 哲也,吉田 絢子,山上 聡,相原 一,宮井 尊史,臼井 智彦.
    • Organizer
      第127回日本眼科学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] インストラクションコース 円錐角膜アップデート2023

    • Author(s)
      吉田 絢子他
    • Organizer
      第38回JSCRS学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 円錐角膜眼における前眼部OCTデンシトメトリー値の評価2023

    • Author(s)
      吉田 絢子,脇 まどか,難波 広幸,臼井 智彦.
    • Organizer
      第77回日本臨床眼科学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 円錐角膜眼での網膜厚、脈絡膜厚の不均一性2023

    • Author(s)
      栗原 智行,難波 広幸,鈴木 泰賢,吉田 絢子,臼井 智彦
    • Organizer
      第77回日本臨床眼科学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 円錐角膜眼のハードコンタクトレンズ装用に伴う眼瞼下垂の検討2023

    • Author(s)
      星 謙成,檀之上 和彦,吉田 絢子,難波 広幸,臼井 智彦
    • Organizer
      第77回日本臨床眼科学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Nominated Lecture, Detecting corneal transparency changes in keratoconus eyes.2023

    • Author(s)
      Junko Yoshida
    • Organizer
      The 29th Annual Meeting of the Kyoto Cornea Club
    • Related Report
      2023 Annual Research Report
  • [Presentation] 教育セミナー 全層角膜移植の基本手技2023

    • Author(s)
      吉田絢子
    • Organizer
      日本眼科手術学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 教育セミナー 前眼部OCTの活用2023

    • Author(s)
      吉田絢子
    • Organizer
      角膜カンファランス
    • Related Report
      2022 Research-status Report
  • [Presentation] 角膜内皮機能不全患者の部位別角膜厚2022

    • Author(s)
      大本 貴士, 金 みんじぇ, 小野 喬, 豊野 哲也, 吉田 絢子, 臼井 智彦, 山上 聡, 相原 一, 宮井 尊史.
    • Organizer
      日本眼科学会
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Long-term analysis on anterior and posterior surface of ATE-CXL for keratoconus.2022

    • Author(s)
      石井 一葉, 吉田 絢子, 竹渓 友佳子, 北本 昴大, 豊野 哲也, 相原 一, 宮井 尊史.
    • Organizer
      日本眼科学会
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 眼瞼下垂術後の涙液の変化の特徴2022

    • Author(s)
      冨岡真帆、髙木誠二、檀之上和彦、吉田絢子、上村景子、長谷川咲希、臼井智彦
    • Organizer
      日本臨床眼科学会
    • Related Report
      2022 Research-status Report
  • [Presentation] Effective conditions for accelerated transepithelial corneal cross-linking2021

    • Author(s)
      Junko Yoshida, Hitoha Ishii, Koudai Kitamoto, Tetsuya Toyono, Tomohiko Usui, and Takashi Miyai
    • Organizer
      The 7th Asia Cornea Society Biennial Scientific Meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Three-year results of ATE-CXL for pellucid marginal degeneration2021

    • Author(s)
      Hitoha Ishii, Junko Yoshida, Koudai Kitamoto, Tetsuya Toyono, and Takashi Miyai
    • Organizer
      The 7th Asia Cornea Society Biennial Scientific Meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] ペルーシド角膜辺縁変性に対するaccelerated transepithelial crosslinkingの3年成績2021

    • Author(s)
      石井一葉、吉田絢子、北本昂大、豊野哲也、宮井尊史
    • Organizer
      日本眼科学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 角膜クロスリンキング後角膜混濁の定量:Epi-on法とEpi-off法の比較2021

    • Author(s)
      吉田絢子、石井一葉、北本昂大、豊野哲也、臼井智彦、宮井尊史
    • Organizer
      日本臨床眼科学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 高速経上皮角膜クロスリンキングの有効な眼条件についての検討2021

    • Author(s)
      吉田絢子、石井一葉、北本昂大、豊野哲也、臼井智彦、宮井尊史
    • Organizer
      角膜カンファランス2021
    • Related Report
      2020 Research-status Report
  • [Presentation] 角膜内皮移植(DSAEK)の基本手技2021

    • Author(s)
      吉田絢子
    • Organizer
      第44回日本眼科手術学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 自己角膜輪部上皮組織移植後に自己血清点眼を使用し上皮化を維持した1例2021

    • Author(s)
      秋山拓也、稲用絢、北本 昂大 、豊野 哲也 、臼井 智彦 、 宮井 尊史
    • Organizer
      第20回日本再生医療学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Results of accelerated trasnepithelial cros-linking redo on keratoconus2020

    • Author(s)
      石井一葉、吉田絢子、豊野哲也、臼井智彦、山上聡、宮井尊史
    • Organizer
      第124回日本眼科学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Nominated Lecture, Keratoconus progression and surgical treatments2020

    • Author(s)
      Junko Yoshida
    • Organizer
      The 26th Annual Meeting of the Kyoto Cornea Club
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 教育セミナー 「角膜内皮移植の基本手技」2020

    • Author(s)
      吉田 絢子
    • Organizer
      第43回日本眼科手術学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Three-year results of transepithelial crosslinking prospective study2019

    • Author(s)
      Junko Yoshida, Hitoha Ishii, Tetsuya Toyono, Tomohiko Usui, Takashi Miyai
    • Organizer
      第123回日本眼科学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 角膜内皮移植をレビューする2019

    • Author(s)
      吉田絢子
    • Organizer
      日本眼科手術学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Risk factors for recurrent keratoconus after penetrating keratoplasty2018

    • Author(s)
      Junko Yoshida, Asahi Fujita, Tetsuya Toyono, Rika Shirakawa, Takashi Miyai, Tomohiko Usui
    • Organizer
      日本眼科学会
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparison between recurrent and naïve keratoconus in cases with acute hydrops2018

    • Author(s)
      Asahi Fujita, Junko Yoshida, Tetsuya Toyono, Rika Shirakawa, Takashi Miyai, Tomohiko Usui
    • Organizer
      日本眼科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Acute hydrops of recurrent keratoconus after penetrating keratoplasty may occur in a different way from that of naïve keratoconus2018

    • Author(s)
      Asahi Fujita Junko Yoshida, Tetsuya Toyono, Rika Shirakawa, Takashi Miyai, Tomohiko Usui
    • Organizer
      ARVO
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 全層移植後長期経過例での前眼部OCTによる角膜形状解析と円錐角膜再発との関連2018

    • Author(s)
      吉田絢子、 藤田あさひ、豊野哲也、白川理香、宮井尊史、臼井智彦
    • Organizer
      日本臨床眼科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Characteristics and risk factors of keratoconus progression after penetrating keratoplasty over long term: Anterior segment optical coherence tomography evaluation2018

    • Author(s)
      Junko Yoshida, Asahi Fujita, Tetsuya Toyono, Rika Shirakawa, Takashi Miyai, Tomohiko Usui
    • Organizer
      Korean ophthalmological society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2018-04-23   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi