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Expression profiles of lncRNA in keloid fibroblasts

Research Project

Project/Area Number 18K17005
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56070:Plastic and reconstructive surgery-related
Research InstitutionNagoya University (2020)
Nippon Medical School (2018-2019)

Principal Investigator

Aoki Masayo  名古屋大学, 医学系研究科, 特任講師 (40465282)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordslncRNA / ケロイド / 細胞外マトリックス / 線維芽細胞 / マトリックス分解酵素 / 創傷治癒
Outline of Final Research Achievements

Long non-coding RNA was comprehensively analyzed in keloid fibroblasts, which are intractable cutaneous fibrotic lesions. The gene expression of matrix metalloproteinase (MMP)-1,3, which is an enzyme that degrades extracellular matrix, is decreased in keloids. lncRNA encoded near chromosome 11q22.2, where these enzymes are located, was analyzed. The increased expression of LINC00900 (5.9-fold) was confirmed. It was suggested that LINC00900 has some function in fibrotic diseases.

Academic Significance and Societal Importance of the Research Achievements

lncRNAは、タンパクをコードしないものの、生体の様々なプロセスに関与する。しかし、大部分のlncRNAの機能は未だ不明である。今回の研究課題で、これまで少なかったケロイド線維芽細胞(継代0代)における遺伝子発現プロファイルを構築することができた。これにより、ケロイドに関与する機能性lncRNA研究の発展が期待される。さらに、他の臓器の線維性疾患における機能性lncRNA研究への応用や、未だ機能が不明であるlncRNAの機能特定に貢献すると考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (14 results)

All 2020 2019 Other

All Int'l Joint Research (2 results) Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (4 results) (of which Int'l Joint Research: 3 results)

  • [Int'l Joint Research] Roswell Park CCC(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Virginia Commonwealth University/Roswell Park CCC(米国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Direct Delivery of Apatite Nanoparticle-Encapsulated siRNA Targeting TIMP-1 for Intractable Abnormal Scars2020

    • Author(s)
      Aoki Masayo、Matsumoto Noriko M.、Dohi Teruyuki、Kuwahawa Hiroaki、Akaishi Satoshi、Okubo Yuri、Ogawa Rei、Yamamoto Hirofumi、Takabe Kazuaki
    • Journal Title

      Molecular Therapy - Nucleic Acids

      Volume: 22 Pages: 50-61

    • DOI

      10.1016/j.omtn.2020.08.005

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gene Expression Profile of Isolated Dermal Vascular Endothelial Cells in Keloids2020

    • Author(s)
      Matsumoto Noriko M.、Aoki Masayo、Okubo Yuri、Kuwahara Kosuke、Eura Shigeyoshi、Dohi Teruyuki、Akaishi Satoshi、Ogawa Rei
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 8 Pages: 658-658

    • DOI

      10.3389/fcell.2020.00658

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The immunosuppressant fingolimod (FTY720) for the treatment of mechanical force-induced abnormal scars.2020

    • Author(s)
      Aoki M, Kondo A, Matsunaga N, Honda A, Okubo Y, Takabe K, Ogawa R
    • Journal Title

      Journal of Immunology Research

      Volume: 2020 Pages: 7057295-7057295

    • DOI

      10.1155/2020/7057195

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Combination Therapy Composed of Surgery, Postoperative Radiotherapy, and Wound Self-management for Umbilical Keloids2020

    • Author(s)
      Dohi Teruyuki、Kuribayashi Shigehiko、Aoki Masayo、Tosa Mamiko、Akaishi Satoshi、Ogawa Rei
    • Journal Title

      Plastic and Reconstructive Surgery - Global Open

      Volume: 8 Issue: 10 Pages: e3181-e3181

    • DOI

      10.1097/gox.0000000000003181

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Geometric analysis and a retrospective cohort study on the usefulness of fascial tensile reductions in severe keloid surgery.2019

    • Author(s)
      Tsuge T, Aoki M, Akaishi S, Dohi T, Yamamoto H, Ogawa R
    • Journal Title

      Surgery

      Volume: 167 Issue: 2 Pages: 504-509

    • DOI

      10.1016/j.surg.2019.07.028

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The roles of sphingosine kinases in skin aging.2019

    • Author(s)
      Aoki M, Aoki H, Mukhopadhyay P, Katsuta E, Takabe K
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 139 Issue: 4 Pages: 951-953

    • DOI

      10.1016/j.jid.2018.06.192

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cytochrome P450 genes play central roles in transcriptional response by keratinocytes to a high-voltage alternating current electric field.2019

    • Author(s)
      Aoki M, Matsumoto NM, Okubo Y, Ogawa R
    • Journal Title

      Bioelectrochemistry

      Volume: 126 Pages: 163-171

    • DOI

      10.1016/j.bioelechem.2018.11.014

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sphingosine-1-Phosphate Facilitates Skin Wound Healing by Increasing Angiogenesis and Inflammatory Cell Recruitment with Less Scar Formation2019

    • Author(s)
      Masayo Aoki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20(14) Issue: 14 Pages: 3381-3397

    • DOI

      10.3390/ijms20143381

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Sphingosine-1-Phospate Enhances Both Excisional and Burn Wound Healing with Less Scaring.2019

    • Author(s)
      Aoki M, Tsuge T, Aoki H, Mukhopadhyay P, Yamamoto H, Matsumoto NM, Toyohara E, Ogawa R, Takabe K
    • Organizer
      14th Annual Academic Surgical Congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Apatite Nanoparticle-encapsulated siRNA Targeting Tissue Inhibitor of Metalloprotease-1 for the Treatment of Hypertrophic Scars and Keloids2019

    • Author(s)
      Masayo Aoki, Noriko M Matsumoto, Azusa Honda, Yuri Okubo, Rei Ogawa, Hirofumi Yamamoto, Kazuaki Takabe, and, Takashi Okada
    • Organizer
      第25回日本遺伝子細胞治療学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Geometric Analysis and a Retrospective Cohort Study on the Usefulness of Fascial Tensile Reductions in Severe Keloid Surgery.2019

    • Author(s)
      Tsuge T, Aoki M, Akaishi S, Dohi T, Yamamoto H, Ogawa R
    • Organizer
      14th Annual Academic Surgical Congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Topical Injection of the Immunosuppressant Fingolimod (FTY720) Inhibits Mechanical Force-induced Hypertrophic Scarring.2019

    • Author(s)
      Kondo A, Aoki M, Matsunaga N, Honda A, Okubo Y, Takabe K, Ogawa R
    • Organizer
      14th Annual Academic Surgical Congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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