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Comprehensive analysis of fusobacterial coaggregation factors associating with subgingival plaque formation

Research Project

Project/Area Number 18K17028
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57020:Oral pathobiological science-related
Research InstitutionKagawa University

Principal Investigator

Tada Ayano  香川大学, 医学部, 助教 (80779463)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsF. nucleaetum / 共凝集 / バイオフィルム / F. nucleatum / フソバクテリウム / 外膜タンパク質 / 菌叢解析 / 歯周病 / 次世代シークエンス
Outline of Final Research Achievements

Fusobacterium nucleatum plays an important role in oral biofilm formation by coaggregating with diverse oral microbes. We prepared VHH antibody to outer membrane protein FadA of F. nucleatum and used for pull-down assay to identify the oral bacteria that coaggregate with this oral anaerobe. The results showed that F. nucleatum preferentially aggregates with Actinomyces naeslandii. In addition, we found that the cell-free culture supernatant of A. naesulandii enhances the coaggregative property of F. nucleatum and this effect was not observed when paraformaldehyde-fixed F. nucleatum. These results indicate that F. nucleatum alter its coaggregative property in response to the signaling molecules produced from oral microbiota.

Academic Significance and Societal Importance of the Research Achievements

F. nucleatumは歯周病関連細菌であり、単独でのバイオフィルム形成能は低いが、多様な口腔細菌と共凝集することで強固で複雑な口腔バイオフィルム形成と成熟に重要な役割を果たしている。また、F. nucleatumは大腸癌など様々な全身疾患との関連性が報告され、注目されている。しかしながら、本菌種がどのように他の口腔内細菌を認識し、自己の凝集能を制御しているのか、そのメカニズムは解明されていない。本研究によるF. nucleatumの共凝集の分子メカニズムの解明は新たな歯周疾患の治療および予防法の開発に多大な情報を与えるものである。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (7 results)

All 2020 2019 2018

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (3 results)

  • [Journal Article] Effect of thymoquinone on Fusobacterium nucleatum-associated biofilms and inflammation2020

    • Author(s)
      Ayano Tada, Haruyuki Nakayana-Imaohji, Hisashi Yamasaki, Miad Elahi, Tamiko Nagao, Hirofumi Yagi, Masao Ishikawa, Koji Shibuya, Tomomi Kuwahara
    • Journal Title

      Molecular Medicine Reports

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of a recombinant Bacteroides fragilis sialidase expressed in Escherichia coli.2018

    • Author(s)
      Yamamoto T, Ugai H, Nakayama-Imaohji H, Tada A, Elahi M, Houchi H, Kuwahara T.
    • Journal Title

      Anaerobe.

      Volume: 50 Pages: 69-75

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] L-histidine augments the oxidative damage against Gram-negative bacteria by hydrogen peroxide.2018

    • Author(s)
      Nagao T, Nakayama-Imaohji H, Elahi M, Tada A, Toyonaga E, Yamasaki H, Okazaki K, Miyoshi H, Tsuchiya K, Kuwahara T.
    • Journal Title

      Int J Mol Med.

      Volume: 41 Pages: 2847-2854

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ethanolamine utilization supports Clostridium perfringens growth in infected tissues.2018

    • Author(s)
      Yagi H, Nakayama-Imaohji H, Nariya H, Tada A, Yamasaki H, Ugai H, Elahi M, Ono T, Kuwahara T.
    • Journal Title

      Microb Pathog.

      Volume: 119 Pages: 200-207

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Fusobacterium含有バイオフィルムに対するチモキノンの洗浄効果2019

    • Author(s)
      多田彩乃、桑原知巳
    • Organizer
      第39回日本歯科薬物療法学会総会・学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] チモキノンのFusobacterium nucleatum混合バイオフィルムに対する効果2018

    • Author(s)
      多田彩乃、石川正夫、渋谷耕司、桑原知巳
    • Organizer
      第67回日本口腔衛生学会・総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Fusobacterium含有バイオフィルムに対するチモキノンの洗浄効果2018

    • Author(s)
      多田彩乃、桑原知巳
    • Organizer
      第39回日本歯科薬物療法学会総会・学術大会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2021-02-19  

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