| Project/Area Number |
18K17044
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57030:Conservative dentistry-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 抗菌性 / イオン徐放 / バイオアクティブガラス / 根面う蝕 / 歯学 |
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| Outline of Final Research Achievements |
In this study, zinc ion-release and recharge properties of a zinc (Zn)-containing glass particle and glass ionomer cement for root surface restoration incorporating Zn-containing glass particles were evaluated. Also, the antibacterial activity against oral bacteria and anti-biofilm effect were assessed in vitro. The Zn-containing glass particle and the cement incorporating Zn-containing glass particles accelerated the release of zinc ion under acidic conditions, which induced antibacterial and anti-biofilm effects. Moreover, the cement containing Zn-containing glass particles had the ability to recharge zinc ion, suggesting that it could demonstrate long-lasting antibacterial and anti-plaque effects.
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| Academic Significance and Societal Importance of the Research Achievements |
近年、バイオアクティブガラスの配合によって修復材料に抗プラーク性を付与する試みが行われているが、それらのほとんどは、バイオアクティブガラスからの初期のイオン溶出に伴う一時的で非常に弱い抗菌効果をねらったものにとどまっている。本研究により、亜鉛含有ガラスを配合したセメントが、口腔細菌に対して効率的かつ長期的に抗菌効果を発現できることが明らかになったことで、多数の細菌が常在する口腔環境において確実な疾患の発生予防を実現するうえで、この修復材料がひとつの基盤技術を提示するものと期待できる。
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