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Development of capture of Exosome by protein

Research Project

Project/Area Number 18K17104
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57040:Regenerative dentistry and dental engineering-related
Research InstitutionTokyo Dental College

Principal Investigator

Yoshida Mitsutaka  東京歯科大学, 歯学部, 臨床講師 (20755029)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsエクソソーム / 細胞外小胞 / バイオマーカー / ペプチド / がん / リキッドバイオプシー / 診断 / 親和性界面 / 液体生検 / 人工ペプチド / 分離カラム / EpCAM / コート剤 / コート材
Outline of Final Research Achievements

Early diagnosis is the key to obtaining good treatment results in cancer treatment. Recently, it has been revealed that vesicles called exosomes released by cancer cells are involved in malignant transformation of cancer. Since exosomes are contained in body fluids throughout the body, it is easy to collect them, which makes them impractical. This research aims to develop a cancer diagnostic method using exosomes.

Academic Significance and Societal Importance of the Research Achievements

細胞は、自身の遺伝情報をふくむエクソソームとよばれる小胞を体液中に放出する。体液中を循環したエクソソームは、他の細胞へ遺伝情報を伝達して性質をかえる。このエクソソームを介した細胞間のコミュニケーションがさまざまな疾患と関連している。がん分野においては、エクソソームを利用してがん細胞が転移のしやすい環境をつくりだしている。本研究では、がん細胞由来のエクソソームを利用した診断法の開発を目標としている。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (1 results)

All 2018

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Preferential capture of EpCAM-expressing extracellular vesicles on solid surfaces coated with an aptamer-conjugated zwitterionic polymer.2018

    • Author(s)
      Mitsutaka Yoshida, Kazuhiro Hibino, Satoshi Yamamoto, Sachiko Matsumura, Yasutomo Yajima, and Kiyotaka Shiba
    • Journal Title

      Biotechnology and Bioengineering

      Volume: Mar;115(3) Issue: 3 Pages: 536-544

    • DOI

      10.1002/bit.26489

    • NAID

      120006795409

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2018-04-23   Modified: 2021-02-19  

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