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Creation of preemptive medical-oriented peri-implantitis prevention strategy by nano-modification of surface oxidation

Research Project

Project/Area Number 18K17106
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57040:Regenerative dentistry and dental engineering-related
Research InstitutionOsaka Dental University

Principal Investigator

Yamawaki Isao  大阪歯科大学, 歯学部, 助教 (70805176)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords糖尿病 / インプラント / 硬組織形成
Outline of Final Research Achievements

In a population of poorly controlled diabetic patients, biochemical markers of bone resorption were reduced in association with improved glycemic control, suggesting that hyperglycemia in patients with type II DM has an adverse impact on bone metabolism.The dental management of patients with diabetes requires special attention to their treatment planning and management, especially post-treatment. Proactive coordination of care with physicians to help ensure proper glycemic control is critical for long-term successful periodontal and implant prothesis. Patients should be assessed regularly for statements of implant. If a patient has DM, it should be treated definitively by establishing glycemic control, and controlling other complications managed in coordination with the patient's physician.

Academic Significance and Societal Importance of the Research Achievements

糖尿病患者の数は増え続けており,今後の展開は広がる一方である。現在注目されているナノテクノロジーの1つである材料表面のナノ構造制御に着目しており,表面構造制御の方法も比較的簡易であることから様々なインプラント材料への表面構造の改変ができ,生体親和性の著しく向上した抗菌性を有したインプラントの創製が期待できる点である。この結果は歯牙喪失リスクの高い糖尿病患者に対して,血糖値コントロールとインプラントのナノ構造制御をすることで,安全にインプラント手術という選択肢を提示することができ,糖尿病患者のQOLの向上に大きく貢献できるものであると考える。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2020 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Effects of α-tocopherol on bone marrow mesenchymal cells derived from type II diabetes mellitus rats2018

    • Author(s)
      Masahiro Noguchi, Isao Yamawaki, Saitatsu Takahashi, YoichiroTaguchi, Makato Umeda.
    • Journal Title

      Journal of Oral Science

      Volume: 60 Issue: 4 Pages: 579-587

    • DOI

      10.2334/josnusd.17-0422

    • NAID

      130007553049

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] P.gingivalis LPS存在下でのグルコース濃度がヒト骨髄間葉系細胞の硬組織分化に及ぼす影響2020

    • Author(s)
      武 慶超, 山脇 勲, 田口 洋一郎, 塩見 慧, 嘉藤 弘仁, 中田 貴也, 高橋 貫之, 梅田 誠
    • Organizer
      第153回2020年度秋季日本歯科保存学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] P.gingivalis LPS存在下における高グルコース環境がヒト骨髄間葉系細胞の硬組織分化に及ぼす影響2018

    • Author(s)
      塩見 慧, 山脇 勲, 田口 洋一郎, 野口 正皓, 中垣 直毅, 山岸 信博, 那須 誉, 本城 佳明, 梅田 誠
    • Organizer
      第61回秋季日本歯周病学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] II型糖尿病モデルラット由来骨髄間葉系細胞に及ぼすα-トコフェロールの影響2018

    • Author(s)
      野口 正皓, 山脇 勲, 田口 洋一郎, 塩見 慧, 小渕 健二朗, 大塚 健司, 中垣 直毅, 山岸 信博, 梅田 誠
    • Organizer
      第61回春季日本歯周病学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Effects of nano modified titanium surface on osteogenic differentiation of diabetes mellitus mesenchymal stromal cells under high glucose concentration.2018

    • Author(s)
      Isao Yamawaki, Yoichiro Taguchi, Satoshi Komasa, Makoto Umeda
    • Organizer
      American Academy of Periodontology 103rd Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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