Program to prevent sarcopenia dysphagia with acute stroke patients.

• Project/Area Number: 18K17129
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Tokyo Dental College
• Principal Investigator: Sakai Katsuhiko 東京歯科大学, 歯学部, 講師 (40433958)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 摂食嚥下障害 / 脳卒中 / サルコペニア / 側頭筋 / MRI / 超音波 / 急性期

Outline of Final Research Achievements

We investigated the relationship between sarcopenia and dysphagia in patient with acute stroke. Temporal muscle thickness measured by MRI was detected as significant explanator of dysphagia severity following stroke.
We also investigated the changes of tongue thickness and temporal muscle thickness after the on set of stroke. These atrophy progressed 2 weeks after the onset of stroke. The result suggested that stroke-related sarcopenia may occur in mastication and swallowing muscles.

Academic Significance and Societal Importance of the Research Achievements

本研究において、脳卒中発症後の摂食嚥下障害にサルコペニアが強く関与していることが明らかになった。脳卒中後の摂食嚥下リハビリテーションにおいて、従来の神経学的なアプローチに加えて、廃用の予防や低栄養の予防を目的とした早期からの介入が重要であることが示唆された。

Research Products

• [Journal Article] Temporal muscle thickness is associated with the severity of dysphagia in patients with acute stroke (2021)
  • Author(s): Sakai Katsuhiko、Katayama Masateru、Nakajima Junko、Inoue Satoshi、Koizumi Kenzo、Okada Satoshi、Suga Sadao、Nomura Takeshi、Matsuura Nobuyuki
  • Journal Title: Archives of Gerontology and Geriatrics Volume: 96 Pages: 104439-104439
  • DOI: 10.1016/j.archger.2021.104439
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Effect of sarcopenia in masticatory and swallowing muscles on oropharyngeal dysphagia in patients with acute stroke (2021)
  • Author(s): Katsuhiko Sakai, Masateru Katayama, Yusuke Matsumoto, Kentaro Honda, Nana Morita, Junko Nakajima, Dai Kamamoto, Sadao Suga, Takeshi Nomura, Nobuyuki Matsuura
  • Organizer: Dysphagia Research Society2021
• [Presentation] 多職種による脳卒中急性期患者の食支援 (2019)
  • Author(s): 小松万純, 酒井克彦, 綿引美香, 大屋朋子, 齋藤寛一, 野村武史
  • Organizer: 第30回日本老年歯科医学会学術大会
• [Presentation] 急性期脳卒中患者における摂食嚥下機能と側頭筋萎縮の関連性の検討 (2019)
  • Author(s): 酒井克彦, 小松万純, 齋藤寛一, 蔵本千夏, 片山正輝, 菅 貞郎, 野村武史
  • Organizer: 第25回 日本摂食・嚥下リハビリテーション学会学術大会
• [Presentation] 急性期脳卒中患者に対する多職種での食事回診の取り組み (2019)
  • Author(s): 小松万純、酒井克彦、山﨑雅恵、秀島能、直江三善、財津愛、大屋朋子、片山正輝、菅貞郎、野村武史
  • Organizer: 第308回東京歯科大学学会・総会