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Genetic analysis of immunological status in oral cancer patients and applications for cancer immunotherapy

Research Project

Project/Area Number 18K17202
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionKumamoto University

Principal Investigator

Hirayama Masatoshi  熊本大学, 病院, 非常勤診療医師 (50779171)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords口腔癌 / 癌免疫療法 / ペプチドワクチン療法 / 癌ペプチドワクチン療法 / 免疫チェックポイント阻害薬 / 腫瘍免疫
Outline of Final Research Achievements

We conducted the clinical trial of peptide-based cancer vaccines as an adjuvant therapy for oral cancer patients. In this study, we harvested peripheral blood mononuclear cells (PBMCs) from these patients and confirmed the presence of the peptide-specific cytotoxic T lymphocytes (CTLs) and the frequencies of M2-macrophages, NK cells, and regulatory T cells by using flow cytometry. In addition, we analyzed the expression of immunologically relevant genes in oral cancer tissues by using NanoString Technologies. Furthermore, we analyzed the concentration of IL-6 in serum collected from oral cancer patients received peptide-based cancer vaccines by ELISA. From now, we analyze the association between these data and clinical efficacy.

Academic Significance and Societal Importance of the Research Achievements

進行口腔癌に対しては、以前より手術療法に加えて放射線療法や化学療法を組み合わせることが一 般的である。しかし、口腔癌患者の5年生存率は過去30年間ほとんど変化しておらず、抗PD-1抗体療法を含む癌免疫療法が口腔癌治療のブレークスルーとなることが期待される。癌免疫療法は、患者個人の免疫状態によってその効果は大きく異なるとされるが、口腔癌患者における患者個々の免疫状態の解析は不十分な面がある。したがって、本研究の社会的意義は大きいと考える。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (1 results)

  • [Journal Article] HMGA2 Contributes to Distant Metastasis and Poor Prognosis by Promoting Angiogenesis in Oral Squamous Cell Carcinoma.2019

    • Author(s)
      Sakata J,Hirosue A,Yoshida R,Kawahara K,Matsuoka Y,Yamamoto T,Nakamoto M,Hirayama M,Takahashi N,Nakamura T,Arita H,Nakashima H,Nagata M,Hiraki A,Shinohara M,Nakayama H
    • Journal Title

      International journal of molecular sciences

      Volume: 20 Issue: 10 Pages: 2473-2473

    • DOI

      10.3390/ijms20102473

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bladder cancer-associated cancer-testis antigen-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes induced CD4+ T cells expressing converged T-cell receptor genes in vitro2018

    • Author(s)
      Tsuruta Miki、Ueda Shohei、Yew Poh Yin、Fukuda Isao、Yoshimura Sachiko、Kishi Hiroyuki、Hamana Hiroshi、Hirayama Masatoshi、Yatsuda Junji、Irie Atsushi、Senju Satoru、Yuba Eiji、Kamba Tomomi、Eto Masatoshi、Nakayama Hideki、Nishimura Yasuharu
    • Journal Title

      OncoImmunology

      Volume: 7 Issue: 4 Pages: 1415687-1415687

    • DOI

      10.1080/2162402x.2017.1415687

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Identification of bladder cancer-associated cancer-testis antigens-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes2018

    • Author(s)
      Yasuharu Nishimura, Miki Tsuruta, Shohei Ueda, Poh Yin Yew, Isao Fukuda, Sachiko Yoshimura, Hiroyuki Kishi, Hiroshi Hamana, Masatoshi Hirayama, Junji Yatsuda, Atsushi Irie, Satoru Senju, Eiji Yuba, Tomomi Kamba, Masatoshi Eto and Hideki Nakayama
    • Organizer
      AACR Annual Meeting 2018
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2021-02-19  

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