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Involvement of SASP in bone microenvironment

Research Project

Project/Area Number 18K17214
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionHyogo Medical University

Principal Investigator

Tamaoka Joji  兵庫医科大学, 医学部, 助教 (60755578)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨微小環境 / SASP / TGF-β
Outline of Final Research Achievements

The purpose of this study was to elucidate the effects of aging on osteoclast precursor cell proliferation, differentiation and SASP. It is considered that senescent osteoclast progenitor cells have reduced osteoclast differentiation potential due to decreased expression of RANK. In addition, the expression of SASP factors (iNOS, TGF-β1, HIF) was increased in senescent osteoclast progenitor cells. It is thought that it may be associated with inflammatory bone diseases such as rheumatoid arthritis due to increased production of inflammatory cytokines.

Academic Significance and Societal Importance of the Research Achievements

老化は未解明な生命現象であり、骨リモデリングが行われる骨微小環境においても例外ではない。骨リモデリングは破骨細胞と骨芽細胞による連関した制御システムであり、このバランスの破綻がさまざまな骨疾患につながる。近年、老化を起こした細胞は、単に細胞増殖を停止しているのではなく、炎症性サイトカインなどさまざまなタンパク質を分泌していることが明らかになった。この分泌現象はSASP(senescence-associated secretory phenotype)と呼ばれているが、骨微小環境との関連の報告は少なく,本研究は価値のあるものと考えている。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2020 2019

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (1 results)

  • [Journal Article] Osteonecrosis of the jaws caused by bisphosphonate treatment and oxidative stress in mice2019

    • Author(s)
      Tamaoka J, Takaoka K, Hattori H, Ueta M, Maeda H, Yamamura M, Yamanegi K, Noguchi K, Kishimoto H
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 17 Pages: 1440-1448

    • DOI

      10.3892/etm.2018.7076

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of TGF β1 on the migration and morphology of RAW264.7 cells in vitro2019

    • Author(s)
      Ueta M, Takaoka K, Yamamura M, Maeda H, Tamaoka J, Nakano Y, Noguchi K, Kishimoto H.
    • Journal Title

      Mol Med Rep

      Volume: 20 Pages: 4331-9

    • DOI

      10.3892/mmr.2019.10662

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 破骨細胞前駆細胞の老化におけるSASPへの影響2020

    • Author(s)
      服部洋一, 高岡一樹, 玉岡丈二, 上田美帆, 押谷将之, 野口一馬, 岸本裕充
    • Organizer
      第74回日本口腔科学会学術集会
    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2021-02-19  

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