A novel pathophysiological mechanism of dry mouth

• Project/Area Number: 18K17219
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Niigata University
• Principal Investigator: Kishikawa Sari 新潟大学, 研究推進機構, 特任助教 (50781358)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 唾液腺 / ドライマウス / GABAB受容体

Outline of Final Research Achievements

we confirmed that GABA B receptors were expressed in human salivary gland cells. In addition, to clarify whether high glucose condition induces cell death or not, we cultured human salivary gland cells under high or low glucose condition. In the future, we will investigate the relationship between GABA B receptors and cell death markers to elucidate the macanism of dry mouse.

Academic Significance and Societal Importance of the Research Achievements

抑制性の神経伝達物質であるγ-アミノ酪酸（GABA）が唾液分泌に対してどのような働きをしているかについてはわかっていない。研究の結果、申請者は唾液腺にGABA B受容体が発現していることを見出した。しかし、唾液に対してどのような作用、修飾を行っているかについては今後の研究課題である。