| Project/Area Number |
18K17247
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57070:Developmental dentistry-related
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Usumi-Fujita Risa 東京医科歯科大学, 東京医科歯科大学病院, 助教 (90706946)
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| Project Period (FY) |
2018-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ペリオスチン / スプライシングバリアント / 軟骨形成 / 歯科矯正 / 咬合機能低下 / 歯科矯正学 / 咬合刺激低下 / LIPUS |
|---|
| Outline of Final Research Achievements |
The role of each variant in cartilage formation and osteogenesis in the craniofacial region is summarized in the paper. Specifically, C56BL6 / N mice were used as the control group, as well as mice of each variant type, and the effects of each variant were measured morphologically and histologically; Micro-CT imaging showed that ΔEx17, ΔEx21, and ΔEx17&21 craniofacial bones, particularly in the mandible, were smaller values were observed, focusing on the mandibular head, indicating that the lack of Ex17 or Ex21 in periostin tends to lead to inadequate chondrocyte differentiation, resulting in smaller craniofacial bones.
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| Academic Significance and Societal Importance of the Research Achievements |
ペリオスチンの各スプライシングバリアントの役割について検討した顎顔面領域の研究は皆無である。特に軟骨細胞肥大に重要な役割を果たし、exon17については軟骨形成、骨形成の抑制につながっている可能性が示唆された。
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