| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Formation of scars after treatment for cleft palate surgery is a big problem. The main factor of scarring is that the fibroblasts at the surgical site produce large amounts of collagen. TGF-β promotes Collagen production. Therefore, we focused on the binding of TGF-β to the elastic fiber component MAGP-1. It was found that cultured fibroblasts increased TGF-β1 and MAGP-1 mRNA expression with tension, and that MAGP-1 and TGFβ-1 coexisted as a complex. MAGP-1 may capture TGF-β and prevent it from binding to cells, and administration of MAGP-1 to cleft palate surgical wounds may be useful as an approach to prevent scarring.
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