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Establishment of a method for controlling autonomic nervous activity by hearing-Study and clinical application in clock gene-deficient mice-

Research Project

Project/Area Number 18K17287
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionKagoshima University

Principal Investigator

Yamashita Kaoru  鹿児島大学, 医歯学域鹿児島大学病院, 助教 (50762613)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords聴覚 / 歯科治療 / 自律神経 / 音楽 / 心理 / 脳波 / 抜歯 / 時計遺伝子 / 自律神経系 / 心拍変動 / 歯科 / 心拍変動解析 / 心理状態
Outline of Final Research Achievements

Auditory stress, pain, and anxiety during dental treatment can cause medical emergency due to fluctuations in autonomic nervous activity. We analyzed the effect of listening to music during dental treatment and hypothesized that it is possible to control autonomic nervous activity with music to construct a safe dental treatment environment. Therefore, we studied the effect of music on the autonomic nervous system and the patient’s psychological state using the Yamashita model ー which is an established method for evaluating autonomic nervous system activity ー during extraction of the impacted mandibular third molar. We reported in an international journal that listening to music reduces sympathetic nervous activity during tooth extraction and reduces anxiety.

Academic Significance and Societal Importance of the Research Achievements

本研究は、下顎埋伏智歯抜歯中の音楽聴取が切開剥離、骨削合、分割中の交感神経活動を低下させ不安を軽減することを見出した初めての研究である。計測方法と評価方法を確立し、自律神経モニタリングを可能にした点、術者など条件を揃えた上で計測した点、処置ごとの自律神経活動、循環動態の変化をとらえ、音楽聴取の有用性を処置ごとにとらえた点、術前5項目のアンケート(MDAS)のスコアが自律神経活動の状態の予測因子となることを見出した点、歯科治療中のバイタルサインには現れない神経学的な変化をとらえ、患者管理の質の向上に役立つ可能性のある知見を得た点に学術的意義・社会的意義があると考える。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (25 results)

All 2020 2019 2018 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 7 results) Presentation (14 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Effects of intravenous sedation on autonomic nerve activity and the psychological state during tooth extraction: A prospective non‐randomized controlled trial2020

    • Author(s)
      Uchino Minako、Yamashita Kaoru、Kibe Toshiro、Shidou Rumi、Kohjitani Atsushi、Sugimura Mitsutaka
    • Journal Title

      Oral Science International

      Volume: ー Issue: 2 Pages: 1-6

    • DOI

      10.1002/osi2.1094

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] General Anesthesia During Lip Repair and Palatoplasty After Glenn Surgery2020

    • Author(s)
      Yamashita Kaoru、Kibe Toshiro、Kohjitani Atsushi、Higa Yurina、Niiro Ayako、Uchino Minako、Aoyama Kanae、Shidou Rumi、Hashiguchi Kohei、Sugimura Mitsutaka
    • Journal Title

      Anesthesia Progress

      Volume: 67 Issue: 2 Pages: 107-108

    • DOI

      10.2344/anpr-67-02-05

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Difference in the Effects of Lidocaine With Epinephrine and Prilocaine With Felypressin on the Autonomic Nervous System During Extraction of the Impacted Mandibular Third Molar: A?Randomized Controlled Trial2020

    • Author(s)
      Yamashita Kaoru、Kibe Toshiro、Shidou Rumi、Kohjitani Atsushi、Nakamura Norifumi、Sugimura Mitsutaka
    • Journal Title

      Journal of Oral and Maxillofacial Surgery

      Volume: 78 Issue: 2 Pages: 215.e1-215.e8

    • DOI

      10.1016/j.joms.2019.09.019

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The State Anxiety Inventory Is Useful for Predicting the Autonomic Nervous System State of Patients Before the Extraction of an Impacted Mandibular Third Molar2020

    • Author(s)
      Yamashita Kaoru、Kibe Toshiro、Aoyama Kanae、Ohno Sachi、Kohjitani Atsushi、Sugimura Mitsutaka
    • Journal Title

      Journal of Oral and Maxillofacial Surgery

      Volume: 78 Issue: 4 Pages: 538-544

    • DOI

      10.1016/j.joms.2019.11.030

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Time to Recovery of Feeding After Alveolar Bone Graft Is Associated With Postoperative Nausea and Vomiting Within 2 Hours in Children2019

    • Author(s)
      Yamashita Kaoru、Kibe Toshiro、Ohno Sachi、Uchino Minako、Higa Yurina、Niiro Ayako、Nakamura Norifumi、Sugimura Mitsutaka
    • Journal Title

      Clinical Medicine Insights: Pediatrics

      Volume: 13

    • DOI

      10.1177/1179556519855387

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Effects of Music Listening During Extraction of the Impacted Mandibular Third Molar on the Autonomic Nervous System and Psychological State2019

    • Author(s)
      Yamashita Kaoru、Kibe Toshiro、Ohno Sachi、Kohjitani Atsushi、Sugimura Mitsutaka
    • Journal Title

      Journal of Oral and Maxillofacial Surgery

      Volume: ー Issue: 6 Pages: 1153.e1-1153.e8

    • DOI

      10.1016/j.joms.2019.02.028

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] グレン循環患児における口唇形成・口蓋形成術に対する全身麻酔経験2019

    • Author(s)
      山下 薫, 岐部俊郎, 糀谷 淳, 比嘉憂理奈, 新納彩子, 内野美菜子, 青山歌奈絵, 四道瑠美, 橋口浩平, 杉村光隆
    • Journal Title

      日本歯科麻酔学会雑誌

      Volume: 47 Pages: 65-67

    • NAID

      130007632927

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predictive Factors of Postoperative Blood Pressure Abnormalities Following a Minor-to-Moderate Surgery2018

    • Author(s)
      Yamashita Kaoru、Kohjitani Atsushi、Miyata Masaaki、Ohno Sachi、Tohya Akina、Ohishi Mitsuru、Sugimura Mitsutaka
    • Journal Title

      International Heart Journal

      Volume: 59 Issue: 6 Pages: 1359-1367

    • DOI

      10.1536/ihj.17-612

    • NAID

      130007521688

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2018-11-30
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recovery of Endothelial Function after Minor-to-Moderate Surgery Is Impaired by Diabetes Mellitus, Obesity, Hyperuricemia and Sevoflurane-Based Anesthesia2018

    • Author(s)
      Ohno S, Kohjitani A, Miyata M, Tohya A, Yamashita K, Hashiguchi T, Ohishi M, Sugimura M.
    • Journal Title

      International Heart Journal

      Volume: 59 Issue: 3 Pages: 559-565

    • DOI

      10.1536/ihj.17-143

    • NAID

      130007378203

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2018-05-31
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of glucose-insulin infusion during major oral and maxillofacial surgery on postoperative complications and outcomes.2018

    • Author(s)
      Tohya A, Kohjitani A, Ohno S, Yamashita K, Manabe Y, Sugimura M.
    • Journal Title

      JA Clinical Reports

      Volume: 4 Issue: 1 Pages: 9-9

    • DOI

      10.1186/s40981-018-0148-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] エピネフリン添加リドカインとフェリプレシン添加プリロカインによる局所麻酔が自律神経系と循環動態に与える影響の評価;ランダム化比較試験2020

    • Author(s)
      山下 薫, 岐部俊郎, 四道瑠美, 糀谷 淳, 杉村光隆
    • Organizer
      日本歯科麻酔学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 歯科・口腔外科手術患者のバイオマーカー、左室拡張能・術後循環器系異常との関連2020

    • Author(s)
      四道瑠美, 糀谷 淳, 山下 薫, 大野 幸, 杉村光隆
    • Organizer
      日本歯科麻酔学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] エピネフリン添加リドカインとフェリプレシン添加プリロカインによる局所麻酔が自律神経系と循環動態に与える影響の評価;ランダム化比較試験2020

    • Author(s)
      山下 薫
    • Organizer
      令和2年度 鹿児島大学歯学部同窓会奨励賞 受賞講演
    • Related Report
      2020 Annual Research Report
  • [Presentation] 顎裂部腸骨海綿骨移植術における、術後悪心・嘔吐と摂食回復期間との関連2019

    • Author(s)
      吉野浩史, 岐部俊郎, 山下 薫, 渕上貴央, 手塚征宏, 中村典史
    • Organizer
      第31回小児口腔外科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] グレン循環患児における口唇形成術に対する全身麻酔経験2019

    • Author(s)
      青山歌奈絵, 山下 薫, 岐部俊郎
    • Organizer
      第31回小児口腔外科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 歯科治療中の神経学的評価モデルの確立 -下顎埋伏智歯抜歯中の音楽介入は自律神経系と心理状態に影響を与える-2019

    • Author(s)
      山下 薫, 岐部俊郎, 大野 幸, 糀谷 淳, 杉村光隆
    • Organizer
      第47回日本歯科麻酔学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 歯科・口腔外科手術患者のバイオマーカー、加速度脈波加齢指数と左室拡張能および術後循環器系異常との関連2019

    • Author(s)
      四道瑠美, 糀谷 淳, 山下 薫, 大野 幸, 杉村光隆
    • Organizer
      第47回日本歯科麻酔学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 不眠症に対してエチゾラム内服をしていた舌痛症および口腔乾燥症併発患者に漢方療法が奏功した症例2019

    • Author(s)
      千堂良造, 山口孝二郎, 真鍋庸三, 山形和彰, 山下薫, 杉村光隆
    • Organizer
      第24回日本口腔顔面痛学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 術前の左室拡張機能と、歯科・口腔外科手術後の血圧異常の関連について2019

    • Author(s)
      山下 薫, 糀谷 淳, 宮田 昌明, 大野 幸, 遠矢 明菜. 大石 充, 杉村光隆
    • Organizer
      鹿児島麻酔懇話会
    • Related Report
      2018 Research-status Report
  • [Presentation] Relationship between anesthesia types and postoperative quality of life after iliac crest bone grafting of the alveolar cleft2018

    • Author(s)
      Yamashita K, Kibe T, Sugimura M
    • Organizer
      IFDAS
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 直線偏光近赤外線の星状神経節近傍照射が心臓自律神経系に与える影響2018

    • Author(s)
      真鍋 庸三, 山下 薫, 千堂 良造, 遠矢 明菜, 山形 和彰, 糀谷 淳, 杉村 光隆
    • Organizer
      日本口腔顔面痛学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 口腔癌術治療時に著明な低ナトリウム血症を認め診断治療に苦慮した2例2018

    • Author(s)
      三島 優美子, 後藤 雄一, 別府 真広, 山下 薫, 濱田 倫史, 坂元 亮一, 今村 晴幸, 杉村 光隆, 杉浦 剛
    • Organizer
      日本口腔科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] ラット三叉神経節における組織透明化の応用と細胞体局在の検討2018

    • Author(s)
      千堂 良造, 杉村 光隆, 糀谷 淳, 眞鍋 庸三, 山形 和彰, 山下 薫, 後藤 哲哉
    • Organizer
      日本口腔顔面痛学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 術前の左室拡張機能と、歯科・口腔外科手術後の血圧異常の関連について2018

    • Author(s)
      糀谷 淳, 宮田 昌明, 山下 薫, 四道 瑠美, 大石 充, 杉村光隆
    • Organizer
      日本高血圧学会臨床高血圧フォーラム
    • Related Report
      2018 Research-status Report
  • [Remarks] research map

    • URL

      https://researchmap.jp/yamashita-k/

    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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