Effect of delay of the onsets of diabetes and diabetic angiopathies on health life span and lifetime treatment cost
Project/Area Number |
18K17376
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
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Research Institution | University of Yamanashi |
Principal Investigator |
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Project Period (FY) |
2018-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 2型糖尿病 / 糖尿病性腎症 / 死因 / 痩せ / がん / 虚血性心疾患 / 感染症 / 脳血管疾患 / 寿命 / 細小血管障害 / 大血管障害 / Body mass index / アレルギー疾患 / 細小血管疾患 / 大血管疾患 / 細小血管合併症 / 大血管合併症 / 糖尿病の発症 / 医療費 / 診療報酬明細書(レセプト) / 健康寿命 / スチェルチェス積分 / 糖尿病 / 生涯医療費 / 糖尿病性血管合併症 / 診療報酬請求書データ |
Outline of Final Research Achievements |
1. Among the vascular complications associated with diabetes, mortality was highest in patients with diabetic nephropathy. This was true for all-cause mortality, deaths from cancer, ischaemic heart disease, infectious diseases and cerebrovascular disease. However, mortality from cancer was similar among patients with macrovascular complications, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy.
2. In diabetic patients with diabetic nephropathy, being thin was associated with 1.79 times higher mortality than being of standard weight and slightly overweight. This was considered an equivalent risk factor to being a current smoker, which increased mortality by 1.70-fold.
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Academic Significance and Societal Importance of the Research Achievements |
1. 糖尿病患者のなかで、糖尿病性腎症がもっとも大きな死亡リスクを背負っていることがわかった。その大きな死亡リスクは、日本人の代表的な死亡原因のほとんどでみられた。糖尿病患者で糖尿病性腎症を進展させないための手厚い医療が必要である。 2. 糖尿病患者の寿命が延伸していることにともない、患者のがんによる死亡が多くなった。糖尿病に合併する血管障害の種類にかかわらず、がんを予防し、早期発見することが今後重要になるだろう。 3. 糖尿病患者で喫煙と同程度に、痩せていることが死亡リスクとなっていることがわかった。臨床医は痩せた患者を診たら、死亡のハイリスク群であることを肝に銘じる必要があるだろう。
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Report
(6 results)
Research Products
(119 results)
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[Journal Article] Endothelial Lipase Exerts its Anti-Atherogenic Effect through Increased Catabolism of β-VLDLs2021
Author(s)
Yan H, Niimi M, Wang C, Chen Y, Zhou H, Matsuhida F, Nishijima K, Kitajima S, Nakajima K, Murakami M, Zhang J, Chen YE, Fan J
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 28
Issue: 2
Pages: 157-168
DOI
NAID
ISSN
1340-3478, 1880-3873
Year and Date
2021-02-01
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Risk factors for perforation during endoscopic retrograde cholangiopancreatography in post-reconstruction intestinal tract2019
Author(s)
akano S, Fukasawa M, Shindo H, Takahashi E, Hirose S, Fukasawa Y ,Kawakami S, Hayakawa H, Yokomichi H, Kadokura M, Sato T, Enomoto N
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Journal Title
World Journal of Clinical Cases
Volume: 7
Pages: 1-18
Related Report
Peer Reviewed / Open Access
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[Journal Article] Impact of the Great East Japan Earthquake on Body Mass Index, Weight, and Height of Infants and Toddlers: An Infant Survey2018
Author(s)
Hiroshi YOKOMICHI, Hiroko MATSUBARA, Mami ISHIKURO, Masahiro KIKUYA, Tsuyoshi ISOJIMA, Susumu YOKOYA, Toshiaki TANAKA, Noriko KATO, Shoichi CHIDA, Atsushi ONO, Mitsuaki HOSOYA, Soichiro TANAKA, Shinichi KURIYAMA, Shigeo KURE, Zentaro YAMAGATA
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Journal Title
Journal of Epidemiology
Volume: 28
Issue: 5
Pages: 237-244
DOI
NAID
ISSN
0917-5040, 1349-9092
Year and Date
2018-05-05
Related Report
Peer Reviewed / Open Access
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[Journal Article] Early excessive growth with distinct seasonality in preschool obesity2018
Author(s)
Isojima Tsuyoshi、Kato Noriko、Yokoya Susumu、Ono Atsushi、Tanaka Toshiaki、Yokomichi Hiroshi、Yamagata Zentaro、Tanaka Soichiro、Matsubara Hiroko、Ishikuro Mami、Kikuya Masahiro、Chida Shoichi、Hosoya Mitsuaki、Kuriyama Shinichi、Kure Shigeo
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Journal Title
Archives of Disease in Childhood
Volume: 104
Issue: 1
Pages: 53-57
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] わが国の小児思春期1型糖尿病治療の現状~小児インスリン治療研究会第5コホート研究より~2019
Author(s)
菊池透, 伊藤善也, 横道洋司, 山本幸代, 望月美恵, 浦上達彦, 川村智行, 菊池信行, 横田一郎, 深見真紀, 井原健二, 志賀健太郎, 竹本幸司, 広瀬正和, 雨宮伸, 杉原茂孝
Organizer
第53回日本小児内分泌学会学術集会
Related Report
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[Presentation] Increase trend in proportion of obesity in Japanese paediatric patients with type 1 diabetes2019
Author(s)
Mochizuki M, Kikuchi T, Ito Y, Musha I, Anzou M, Matsuo K, Soneda S, Kobayashi K, Yokomichi H, Yokota I, Kawamura T, Kikuchi N, Urakami T, Matsuua N, Sasaki N, Sugihara S, Amemiya S on behalf of The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes
Organizer
第53回日本小児内分泌学会学術集会
Related Report
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[Presentation] Increase trend in proportions of overweight and obesity in Japanese paediatric patients with type 1 diabetes2019
Author(s)
Mochizuki M, Anzo M, Matsuo K, Soneda S, Ito Y, Musha I, Kobayashi K, Yokomichi H, Matsuura N, Sasaki N, Sugihara S, Kikuchi T, Amemiya S, Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes
Organizer
55th Annual Meeting of the European Association for the Study of Diabetes
Related Report
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[Presentation] グリコアルブミン/ヘモグロビンA1c比の個人別長期一定性への成長変化の影響2019
Author(s)
武者育麻, 望月美恵, 菊池透, 横道洋司, 赤塚淳弥, 大竹明, 菊池信行, 横田一郎, 川村智行, 浦上達彦, 杉原茂孝, 雨宮伸
Organizer
第62回日本糖尿病学会年次学術集会
Related Report
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[Presentation] 脳梗塞の増悪因子であるアクロレインの抗血小板作用2018
Author(s)
梅谷徳彦, 白井俊光, 築地長治, 佐々木知幸, 田村彰吾, 佐藤金夫, 大竹志門, 髙野勝弘, 横道洋司, 尾崎由基男, 井上克枝
Organizer
第40回 日本血栓止血学会学術集会
Related Report
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[Book] 論文を読み解くためのやさしい統計学 改訂第3版2019
Author(s)
阿江竜介, 天野宏紀, 上原里程, 尾島俊之, 黒沢洋一, 佐伯圭吾, 櫻井勝, 杉山裕美, 中村好一, 西信雄, 松原優里, 三浦克之, 村上義孝, 横道洋司, 渡辺至
Total Pages
200
Publisher
診断と治療社
ISBN
9784787823649
Related Report
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