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Association of glycemic variability with cognitive function and subclinical atherosclerosis in a general population of Japanese women

Research Project

Project/Area Number 18K17379
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research InstitutionShiga University of Medical Science

Principal Investigator

Miyazawa Itsuko  滋賀医科大学, 医学部, 特任助教 (20649305)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords血糖変動
Outline of Final Research Achievements

The purpose of this study was to examine the relationship between blood glucose variability and cognitive function and subclinical arteriosclerosis in the general population. General population women (60-85 years old) were randomly selected from Kusatsu City, Shiga Prefecture, and used a low-invasive continuous glucose monitor to obtain blood glucose variability data for one week. Testing was performed in 321 subjects, and valid data were obtained in 307. The mean total blood glucose level was 65.9 ± 16.9 mg/dl and the mean SD was 26.7 ± 9.8 mg/dl. 92.1 ± 13.2% of all blood glucose data were within the optimal blood glucose range (70-180 mg/dl). MAGE, a measure of diurnal variation in blood glucose, averaged 65.9±24.8 mg/dl.

Academic Significance and Societal Importance of the Research Achievements

本研究のような一般住民を対象とした大規模な疫学研究において、血糖変動を調査した報告は国内外において認めず、その実態を報告することに意義があるうえ、本コホートでの認知機能や動脈硬化の検査は国際的に標準化された方法で実施されており、血糖変動との関連を研究するにあたり、学術的にも価値が高い。
本研究の成果は血糖変動という新たな側面から糖尿病、認知症、動脈硬化性疾患に対する予防策を提言できる可能性がある。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2023 2022 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification2022

    • Author(s)
      Ganbaatar Namuun、Kadota Aya、Hisamatsu Takashi、Araki Shinichi、Kume Shinji、Fujiyoshi Akira、Kadowaki Sayaka、Torii Sayuki、Kondo Keiko、Segawa Hiroyoshi、Salman Ebtehal、Miyazawa Itsuko、Yamamoto Takashi、Nakagawa Yoshihisa、Maegawa Hiroshi、Miura Katsuyuki、Ueshima Hirotsugu、for the SESSA Research Group
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 29 Issue: 9 Pages: 1359-1371

    • DOI

      10.5551/jat.63030

    • NAID

      130008106841

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2022-09-01
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Association between renal function and silent cerebrovascular disease in Japanese men2023

    • Author(s)
      Naoko Miyagawa, Naoyuki Takashima, Aya Kadota, Akira Fujiyoshi, Sayuki Torii, Hiroyoshi Segawa, Itsuko Miyazawa, Shinji Kume, Keiko Kondo, Takashi Hisamatsu, Yuichiro Yano, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura, the SESSA Research Group
    • Organizer
      AHA EPI|Lifestyle Scientific Sessions 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 日本人一般住民男性における腎異所性脂肪と肥満指標との関連:滋賀動脈硬化疫学研究(SESSA)2019

    • Author(s)
      宮澤伊都子、大久保孝義、村上陽子、永谷幸裕、佐藤滋高、藤吉朗、 久松隆史、門田文、脇紗也佳、瀬川裕佳、近藤慶子、新田哲久、前川聡、三浦克之、上島弘嗣
    • Organizer
      第40回日本肥満学会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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