| Project/Area Number |
18K17701
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 59010:Rehabilitation science-related
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2018-04-01 – 2023-03-31
|
| Project Status |
Completed (Fiscal Year 2022)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 運動単位数 / MUNE / Martin-Gruber吻合 / 神経再生 / 手根管症候群 / 肘部管症候群 / 神経伝導検査 / 神経吻合 / 末梢神経障害 |
|---|
| Outline of Final Research Achievements |
We have developed the Digital subtraction and New MUNE methods for nerve anastomosis. To our knowledge, these methods are the first simple, non-invasive electrophysiological assessment of nerve anastomoses. The Digital subtraction method is simple and widely useful for anastomotic branches. The MUNE new method for anastomotic branches may be used for a more detailed evaluation of anastomotic branches (end-to-end or some end-to-side anastomoses) with a relatively constant number of motor units. Using these new evaluations, we clarified the characteristics of muscle innervation by the nerve anastomotic branches of the Marin-Gruber anastomosis, which is the most popular variation. We also demonstrated that the anastomotic branches contribute to nerve regeneration in patients with peripheral injury.
|
| Academic Significance and Societal Importance of the Research Achievements |
今回Digital subtraction法およびMUNE新法を開発し，神経吻合における簡便かつ非侵襲的な電気生理学的評価を初めて実現した．また19.5%と頻度の高い破格Marin-Gruber吻合において，神経吻合枝による筋支配の特徴を明らかにし，末梢神経障害合併時に吻合枝が神経再生へ寄与することを示した．本知見は，神経吻合枝を評価する新たな客観的指標を提供し，神経吻合を有する末梢神経障害において，より正確な診断や効果的な治療選択や治療開発に役立つ．更にMarin-Gruber吻合は神経吻合の健常モデルであり，神経移行や神経移植で吻合枝を生じる神経再生医療の発展への貢献が期待される．
|
