| Project/Area Number |
18K17852
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59020:Sports sciences-related
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| Research Institution | Tsukuba University of Technology |
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Principal Investigator |
Matsui Yassuhi 筑波技術大学, 保健科学部, 講師 (80735762)
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| Project Period (FY) |
2018-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2020: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | レーベル遺伝性視神経症 / ミトコンドリアDNA / 心肺持久力 / 視覚障害 / 持久力 / レーベル病 / ミトコンドリア / 無酸素性作業閾値 |
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| Outline of Final Research Achievements |
The purpose of this study is to investigate whether Leber's disease, which is caused by mutations in mitochondrial DNA, affects human endurance. We compared cardiopulmonary endurance in patients with Leber's disease and visually impaired subjects with other diseases. We also investigated whether maximal oxygen uptake and anaerobic work thresholds of patients with Leber's disease could be improved by 6 weeks of high-intensity interval training. Results showed that patients with Reber's disease had lower maximal oxygen uptake and lower anaerobic work threshold than visually impaired patients with other diseases. Furhermore, the patients with Reber's disease showed improvement in maximal oxygen uptake, but not in anaerobic work threshold after 6 weeks of high-intensity interval training.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の意義は，ミトコンドリアDNAの変異により発症するレーベル病患者の持久力，及び持久力に対するトレーニング効果を明らかにすることにより，レーベル病患者において視覚障害者スポーツの競技を選択する際の判断材料として使用できると考えられる．また，レーベル病患者が日常生活を送る際に必要な体力を維持，改善するための方法を考える上での重要な基礎資料となると考えられる．
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