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Identification of sport injury-related genetic polymorphisms in athletes

Research Project

Project/Area Number 18K17863
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionJuntendo University

Principal Investigator

Kumagai Hiroshi  順天堂大学, スポーツ健康科学部, 特任助教 (00794819)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords遺伝子多型 / ケガ / アスリート / 肉離れ / 疲労骨折 / エストロゲン受容体 / アロマターゼ / 女性ホルモン / 傷害 / 血中エストラジオール濃度 / エストロゲン / スポーツ傷害 / 性ホルモン / 性差
Outline of Final Research Achievements

The aim of the present study was to identify sport injury-related genetic polymorphisms in Japanese athletes. Because there was a sex difference in the incidence of sports injury, we focused on sex hormone-related genetic polymorphisms in the present study. We observed that the athletes with the C allele in the ESR1 rs2234693 exhibited a significantly lower risk of skeletal muscle injury as well as muscle stiffness, a risk factor for muscle injury, than those with the T allele. Furthermore, athletes with the T allele in the CYP19A1 rs936306 showed a significantly lower risk of stress fracture than those with the C allele. These findings suggest that estrogen-related genetic polymorphisms, namely ESR1 rs2234693 and CYP19A1 rs936306, are a possible predictor of sports injuries.

Academic Significance and Societal Importance of the Research Achievements

アスリートにおいて、ケガが競技成績に悪影響を及ぼすことは明白であることから、ケガの発生を未然に防ぐ必要がある。ケガのリスクは、年齢、性、遺伝といった内的要因とトレーニング、疲労回復、食事といった外的要因により規定される。これまでに、外的要因に関する研究は数多く行われているが、内的要因に関する研究はほとんど実施されていなかった。本研究では、女性ホルモンであるエストロゲンの作用に関連する遺伝子多型が肉離れなどの筋のケガや疲労骨折などの骨のケガに関連することを明らかにした。これらの研究成果は、遺伝子型に基づいたアスリートの傷害リスクの把握や傷害予防プログラムの構築に寄与すると考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (28 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (7 results) Journal Article (16 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 16 results,  Open Access: 12 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Int'l Joint Research] University of Southern California(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Auckland(ニュージーランド)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Liverpool John Moores University(英国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Kazan State Medical University/Ural State University/South Ural State Medical University(ロシア連邦)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of Southern California(米国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] The University of Auckland(ニュージーランド)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of Cagliari/Italian Sports Medicine Federation(イタリア)

    • Related Report
      2018 Research-status Report
  • [Journal Article] MOTS-c reduces myostatin and muscle atrophy signaling2021

    • Author(s)
      Kumagai Hiroshi、Coelho Ana Raquel、Wan Junxiang、Mehta Hemal H.、Yen Kelvin、Huang Amy、Zempo Hirofumi、Fuku Noriyuki、Maeda Seiji、Oliveira Paulo J.、Cohen Pinchas、Kim Su-Jeong
    • Journal Title

      American Journal of Physiology-Endocrinology and Metabolism

      Volume: 320 Issue: 4 Pages: E680-E690

    • DOI

      10.1152/ajpendo.00275.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationship between serum testosterone concentration and microvascular endothelial function in Japanese men2021

    • Author(s)
      Kumagai Hiroshi, Zempo-Miyaki Asako, Yoshikawa, Toru, Myoenzono Kanae, Tanahashi Koichiro, Akazawa Nobuhiko, Maeda Seiji
    • Journal Title

      Journal of Men’s Health

      Volume: -

    • DOI

      10.31083/jomh.2021.013

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Female Athletes Genetically Susceptible to Fatigue Fracture Are Resistant to Muscle Injury2021

    • Author(s)
      Miyamoto-Mikami E, Kumagai H, Tanisawa K, Taga Y, Hirata K, Kikuchi N, Kamiya N, Kawakami R, Midorikawa T, Kawamura T, Kakigi R, Natsume T, Zempo H, Suzuki K, Kohmura Y, Mizuno K, Torii S, Sakamoto S, Oka K, Higuchi M, Naito H, Miyamoto N, Fuku N
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: Publish Ahead of Print Issue: 9 Pages: 0-0

    • DOI

      10.1249/mss.0000000000002658

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The impact of aerobic fitness on arterial stiffness and adrenal cortex hormones in middle-aged and older adults2020

    • Author(s)
      Akazawa Nobuhiko、Tanahashi Koichiro、Kosaki Keisei、Kumagai Hiroshi、Oikawa Satoshi、Hamasaki Ai、Maeda Seiji
    • Journal Title

      Endocrine Journal

      Volume: 67 Issue: 12 Pages: 1199-1205

    • DOI

      10.1507/endocrj.EJ20-0211

    • NAID

      130007962225

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A rs936306 C/T Polymorphism in the CYP19A1 Is Associated With Stress Fractures2020

    • Author(s)
      Kumagai Hiroshi、Miyamoto-Mikami Eri、Kikuchi Naoki、Kamiya Nobuhiro、Zempo Hirofumi、Fuku Noriyuki
    • Journal Title

      Journal of Strength and Conditioning Research

      Volume: - Issue: 8 Pages: 2322-2325

    • DOI

      10.1519/jsc.0000000000003825

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial-derived peptides in energy metabolism2020

    • Author(s)
      Merry Troy L.、Chan Alex、Woodhead Jonathan S. T.、Reynolds Joseph C.、Kumagai Hiroshi、Kim Su-Jeong、Lee Changhan
    • Journal Title

      American Journal of Physiology-Endocrinology and Metabolism

      Volume: 319 Issue: 4 Pages: E659-E666

    • DOI

      10.1152/ajpendo.00249.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] eQTL variants in COL22A1 are associated with muscle injury in athletes2020

    • Author(s)
      Miyamoto-Mikami Eri、Kumagai Hiroshi、Kikuchi Naoki、Kamiya Nobuhiro、Miyamoto Naokazu、Fuku Noriyuki
    • Journal Title

      Physiological Genomics

      Volume: 52 Issue: 12 Pages: 588-589

    • DOI

      10.1152/physiolgenomics.00115.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition2020

    • Author(s)
      D’Souza Randall F.、Woodhead Jonathan S. T.、Hedges Christopher P.、Zeng Nina、Wan Junxiang、Kumagai Hiroshi、Lee Changhan、Cohen Pinchas、Cameron-Smith David、Mitchell Cameron J.、Merry Troy L.
    • Journal Title

      Aging

      Volume: 12 Issue: 6 Pages: 5244-5258

    • DOI

      10.18632/aging.102944

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regular aerobic exercise improves sexual function assessed by the Aging Males’ Symptoms questionnaire in adult men2020

    • Author(s)
      Kumagai Hiroshi、Myoenzono Kanae、Yoshikawa Toru、Tsujimoto Takehiko、Shimomura Kosei、Maeda Seiji
    • Journal Title

      The Aging Male

      Volume: 12 Issue: 5 Pages: 1-8

    • DOI

      10.1080/13685538.2020.1724940

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The association of HFE gene H63D polymorphism with endurance athlete status and aerobic capacity: novel findings and a meta-analysis2020

    • Author(s)
      Semenova EA, Miyamoto-Mikami E, Akimov EB, Al-Khelaifi F, Murakami H, Zempo H, Kostryukova ES, Kulemin NA, Larin AK, Borisov OV, Miyachi M, Popov DV, Boulygina EA, Takaragawa M, Kumagai H, Naito H, Pushkarev VP, Dyatlov DA, Lekontsev EV, Pushkareva YE, Andryushchenko LB, Elrayess MA, Generozov EV, Fuku N, Ahmetov II
    • Journal Title

      European Journal of Applied Physiology

      Volume: 120 Issue: 3 Pages: 665-673

    • DOI

      10.1007/s00421-020-04306-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Incremental short maximal exercise increases urinary liver‐type fatty acid‐binding protein in adults without CKD2020

    • Author(s)
      Kosaki Keisei、Kamijo‐Ikemori Atsuko、Sugaya Takeshi、Kumamoto Shota、Tanahashi Koichiro、Kumagai Hiroshi、Kimura Kenjiro、Shibagaki Yugo、Maeda Seiji
    • Journal Title

      Scandinavian Journal of Medicine & Science in Sports

      Volume: 30 Issue: 4 Pages: 709-715

    • DOI

      10.1111/sms.13618

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] COL5A1 rs12722 polymorphism is not associated with passive muscle stiffness and sports-related muscle injury in Japanese athletes.2019

    • Author(s)
      Miyamoto-Mikami E, Miyamoto N, Kumagai H, Hirata K, Kikuchi N, Zempo H, Kimura N, Kamiya N, Kanehisa H, Naito H, Fuku N.
    • Journal Title

      BMC Medical Genetics.

      Volume: 20 Issue: 1 Pages: 192-192

    • DOI

      10.1186/s12881-019-0928-2

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deterioration of sexual function is associated with central hemodynamics in adult Japanese men2019

    • Author(s)
      Kumagai Hiroshi、Yoshikawa Toru、Kosaki Keisei、Myoenzono Kanae、Maeda Seiji
    • Journal Title

      Hypertension Research

      Volume: 43 Issue: 1 Pages: 36-44

    • DOI

      10.1038/s41440-019-0336-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of sleep efficiency on salivary metabolite profile and cognitive function during exercise in volleyball athletes.2019

    • Author(s)
      Akazawa Nobuhiko, Kobayashi Naoko, Nakamura Yuki, Kumagai Hiroshi, Choi Youngju, Maeda Seiji.
    • Journal Title

      European Journal of Applied Physiology

      Volume: 119 Issue: 10 Pages: 2215-2223

    • DOI

      10.1007/s00421-019-04205-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of High Physical Fitness in Deterioration of Male Sexual Function in Japanese Adult Men.2019

    • Author(s)
      Kumagai H, Yoshikawa T, Myoenzono K, Kosaki K, Akazawa N, Tanahashi K, Tagawa K, Zempo-Miyaki A, Maeda S.
    • Journal Title

      American Journal of Men's Health

      Volume: 13 Issue: 3 Pages: 1-9

    • DOI

      10.1177/1557988319849171

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness2018

    • Author(s)
      Hiroshi Kumagai、Eri Miyamoto-Mikami、Kosuke Hirata、Naoki Kikuchi、Nobuhiro Kamiya、Seigo Hoshikawa、Hirofumi Zempo、Hisashi Naito、Naokazu Miyamoto、Noriyuki Fuku
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 1 Issue: 1 Pages: 19-26

    • DOI

      10.1249/mss.0000000000001750

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 成人男性における有酸素性運動トレーニングはAMSスコアを改善する2019

    • Author(s)
      熊谷仁、妙圓園香苗、吉川 徹、前田清司
    • Organizer
      第19回日本メンズヘルス医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 運動とテストステロン2019

    • Author(s)
      前田清司、熊谷仁
    • Organizer
      第19回日本メンズヘルス医学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] エストロゲン関連遺伝子多型はウルトラマラソンによる筋損傷に関連する2018

    • Author(s)
      熊谷仁, 宮本(三上)恵里, 徳留信寛, 福典之
    • Organizer
      第26回日本運動生理学会
    • Related Report
      2018 Research-status Report
  • [Presentation] ESR1 rs2234693 polymorphism and sports-related muscle injuries: a case-control association and physiologically functional studies in Japanese population.2018

    • Author(s)
      Hiroshi Kumagai、Eri Miyamoto-Mikami、Kosuke Hirata、Naoki Kikuchi、Nobuhiro Kamiya、Seigo Hoshikawa、Hirofumi Zempo、Hisashi Naito、Naokazu Miyamoto、Noriyuki Fuku
    • Organizer
      23th annual congress of the European College of Sport Science
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ACE I/D polymorphism and muscle injuries in Italian and Japanese elite football players2018

    • Author(s)
      Myosotis Massidda, Eri Miyamoto-Mikami, Hiroshi Kumagai, Carla Maria Cal, Paolo Cugia, Naoki Kikuchi, Marco Scorcu, Noriyuki Fuku
    • Organizer
      35th FIMS World Congress of Sports Medicine
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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