Identification of sport injury-related genetic polymorphisms in athletes
Project/Area Number |
18K17863
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 59020:Sports sciences-related
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Research Institution | Juntendo University |
Principal Investigator |
Kumagai Hiroshi 順天堂大学, スポーツ健康科学部, 特任助教 (00794819)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 遺伝子多型 / ケガ / アスリート / 肉離れ / 疲労骨折 / エストロゲン受容体 / アロマターゼ / 女性ホルモン / 傷害 / 血中エストラジオール濃度 / エストロゲン / スポーツ傷害 / 性ホルモン / 性差 |
Outline of Final Research Achievements |
The aim of the present study was to identify sport injury-related genetic polymorphisms in Japanese athletes. Because there was a sex difference in the incidence of sports injury, we focused on sex hormone-related genetic polymorphisms in the present study. We observed that the athletes with the C allele in the ESR1 rs2234693 exhibited a significantly lower risk of skeletal muscle injury as well as muscle stiffness, a risk factor for muscle injury, than those with the T allele. Furthermore, athletes with the T allele in the CYP19A1 rs936306 showed a significantly lower risk of stress fracture than those with the C allele. These findings suggest that estrogen-related genetic polymorphisms, namely ESR1 rs2234693 and CYP19A1 rs936306, are a possible predictor of sports injuries.
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Academic Significance and Societal Importance of the Research Achievements |
アスリートにおいて、ケガが競技成績に悪影響を及ぼすことは明白であることから、ケガの発生を未然に防ぐ必要がある。ケガのリスクは、年齢、性、遺伝といった内的要因とトレーニング、疲労回復、食事といった外的要因により規定される。これまでに、外的要因に関する研究は数多く行われているが、内的要因に関する研究はほとんど実施されていなかった。本研究では、女性ホルモンであるエストロゲンの作用に関連する遺伝子多型が肉離れなどの筋のケガや疲労骨折などの骨のケガに関連することを明らかにした。これらの研究成果は、遺伝子型に基づいたアスリートの傷害リスクの把握や傷害予防プログラムの構築に寄与すると考えられる。
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] MOTS-c reduces myostatin and muscle atrophy signaling2021
Author(s)
Kumagai Hiroshi、Coelho Ana Raquel、Wan Junxiang、Mehta Hemal H.、Yen Kelvin、Huang Amy、Zempo Hirofumi、Fuku Noriyuki、Maeda Seiji、Oliveira Paulo J.、Cohen Pinchas、Kim Su-Jeong
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Journal Title
American Journal of Physiology-Endocrinology and Metabolism
Volume: 320
Issue: 4
Pages: E680-E690
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Female Athletes Genetically Susceptible to Fatigue Fracture Are Resistant to Muscle Injury2021
Author(s)
Miyamoto-Mikami E, Kumagai H, Tanisawa K, Taga Y, Hirata K, Kikuchi N, Kamiya N, Kawakami R, Midorikawa T, Kawamura T, Kakigi R, Natsume T, Zempo H, Suzuki K, Kohmura Y, Mizuno K, Torii S, Sakamoto S, Oka K, Higuchi M, Naito H, Miyamoto N, Fuku N
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Journal Title
Medicine & Science in Sports & Exercise
Volume: Publish Ahead of Print
Issue: 9
Pages: 0-0
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The association of HFE gene H63D polymorphism with endurance athlete status and aerobic capacity: novel findings and a meta-analysis2020
Author(s)
Semenova EA, Miyamoto-Mikami E, Akimov EB, Al-Khelaifi F, Murakami H, Zempo H, Kostryukova ES, Kulemin NA, Larin AK, Borisov OV, Miyachi M, Popov DV, Boulygina EA, Takaragawa M, Kumagai H, Naito H, Pushkarev VP, Dyatlov DA, Lekontsev EV, Pushkareva YE, Andryushchenko LB, Elrayess MA, Generozov EV, Fuku N, Ahmetov II
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Journal Title
European Journal of Applied Physiology
Volume: 120
Issue: 3
Pages: 665-673
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] COL5A1 rs12722 polymorphism is not associated with passive muscle stiffness and sports-related muscle injury in Japanese athletes.2019
Author(s)
Miyamoto-Mikami E, Miyamoto N, Kumagai H, Hirata K, Kikuchi N, Zempo H, Kimura N, Kamiya N, Kanehisa H, Naito H, Fuku N.
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Journal Title
BMC Medical Genetics.
Volume: 20
Issue: 1
Pages: 192-192
DOI
Related Report
Peer Reviewed / Open Access
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