Elucidation of novel NAD synthesis pathway to develop anti-aging strategy
| Project/Area Number |
18K17921
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 59040:Nutrition science and health science-related
|
|---|
| Research Institution | University of Toyama |
|---|
Principal Investigator |
Yaku Keisuke 富山大学, 学術研究部医学系, 助教 (70761865)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | NAD代謝 / 老化 / NAD / 代謝 |
|---|
| Outline of Final Research Achievements |
Nicotiniamide adenine dinucleotide (NAD) levels in the body decline with age, while replenishment of NAD is expected to slow or reverse aging processes. In this study, we aimed to elucidate the metabolism of Nicotinamide riboside (NR) which is the effective precursor for NAD repletion. We found that NR is digested into Nicotinamide by CD157, then converted into NR by gut microbiota.
|
| Academic Significance and Societal Importance of the Research Achievements |
NADは生命維持に必須であるビタミンB3であり、その体内量を維持することが老化関連疾患の予防・治療に有効であると考えられている。NAD補充方法の中でも前駆体の経口投与は最も簡便であり、効果的なNAD前駆体の探索が行われている。本研究ではNAD補充効率が良いと期待されるNRの消化管内での動態を明らかにした。これらの結果は肥満や糖尿病などの老化関連疾患に対する介入方法を確立する上で重要な知見となる。
|
Report
(4 results)
Research Products
(18 results)
