| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We have found that lysosomal dysfunction is observed in the adipose tissue of metabolic diseases and aging model mice, and that abnormal mitochondria accumulate due to the accompanying decrease in autophagy degradation. In this study, we focused on skeletal muscle and analyzed the effects on lysosomal autophagy function and skeletal muscle function using metabolic diseases and aging models. As a result, it was clarified that these mice had abnormal lysosomal functions. In the future, we plan to analyze the effects of these abnormalities on skeletal muscle.
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