Nutritional solution for chronic kidney disease through the dual maintenance mechanism of renal and skeletal muscle
| Project/Area Number |
18K17966
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KANEKO Ichiro 徳島大学, 大学院医歯薬学研究部(医学域), 助教 (40389515)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ビタミンD / FGF19 / 慢性腎臓病 / サルコペニア / CKDモデル筋培養細胞 / CKD / 慢性腎臓病マウス / 栄養障害 / フレイル |
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| Outline of Final Research Achievements |
In patients with chronic kidney disease (CKD), we investigated the improvement of skeletal muscle atrophy without depending on protein intake because of renal function decline due to protein load. It was suggested that the combined use of fibroblast growth factor 19 (FGF19) and vitamin D can maintain renal function and prevent skeletal muscle atrophy in CKD patients. Since the decline in renal function occurs irreversibly, these results can be expected to lead to new nutritional management for CKD or dialysis patients.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、ビタミンDによる腎保護および筋萎縮改善メカニズムを明らかにした。。また、筋合成に重要な因子としてFGF19の作用を明らかにし、特に慢性腎臓病患者にとってビタミンDと併用することでサルコペニア改善に有用であることが示唆された。近年、慢性腎臓病や透析患者の増加が著しく、本研究の成果は、普段の食事や治療時の栄養管理の改善を介して、健康寿命の延長に貢献できると考えられる。
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation.2019
Author(s)
Fujii T, Segawa H, Hanazaki A, Nishiguchi S, Minoshima S, Ohi A, Tominaga R, Sasaki S, Tanifuji K, Koike M, Arima Y, Shiozaki Y, Kaneko I, Ito M, Tatsumi S, Miyamoto KI
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Journal Title
Clin Exp Nephrol.
Volume: in press
Issue: 7
Pages: 898-907
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Analysis of opossum kidney NaPi-IIc sodium-dependent phosphate transporter to understand Pi handling in human kidney.2019
Author(s)
Fujii T, Shiozaki Y, Segawa H, Nishiguchi S, Hanazaki A, Noguchi M, Kirino R, Sasaki S, Tanifuji K, Koike M, Yokoyama M, Arima Y, Kaneko I, Tatsumi S, Ito M, Miyamoto KI.
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Journal Title
Clin Exp Nephrol
Volume: 23(3)
Issue: 3
Pages: 313-324
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Eldecalcitol Causes FGF23 Resistance for Pi Reabsorption and Improves Rachitic Bone Phenotypes in the Male Hyp Mouse.2018
Author(s)
Kaneko I, Segawa H, Ikuta K, Hanazaki A, Fujii T, Tatsumi S, Kido S, Hasegawa T, Amizuka N, Saito H, Miyamoto KI.
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Journal Title
Endocrinology
Volume: 159(7)
Issue: 7
Pages: 2741-2758
DOI
Related Report
Peer Reviewed / Open Access
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