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Clarification of the regulatory mechanism of ACC2, a regulator of beta-oxidation, by biotin and its application to the prevention of the metabolic syndrome

Research Project

Project/Area Number 18K17974
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionKobe University (2021)
University of Nagasaki (2018-2020)

Principal Investigator

Yuasa Masahiro  神戸大学, 人間発達環境学研究科, 助教 (00756174)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsビオチン / アセチルCoAカルボキシラーゼ(ACC)2 / カルニチンパルミトイルトランスフェラーゼ / β酸化 / エネルギー消費量 / 脂肪消費量 / 肝臓 / 褐色脂肪組織 / Ucp1 / Pgc-1α / β酸化関連酵素 / エネルギー代謝 / アセチルCoAカルボキシラーゼ2 / ラット / アセチルCoAカルボキシラーゼ
Outline of Final Research Achievements

In this study, we investigated the mechanism of biotin-induced inhibition of β-oxidation regulator acetyl CoA carboxylase 2 (ACC2) to prevent and improve metabolic syndrome (MS).
Short-term oral administration of high-dose biotin reduced ACC2 gene expression in the rat liver, but long-term oral administration of safe-dose biotin did not change the hepatic ACC2 gene expression. In both of these experiments, an increase in fat oxidation and plasma adiponectin, and a decrease in white adipose tissue were induced; therefore, biotin may be effective in preventing and improving MS; but the liver ACC2 is not the only factor involved in this mechanism.

Academic Significance and Societal Importance of the Research Achievements

将来的には,MSや生活習慣病の予防のためのビオチンによる栄養療法の提案に資すると考える.現在,食品成分によるMSの予防・改善効果に関する検討が多数行われているが,高濃度での継続的な摂取が肝機能障害を生じさせるなどの副作用がある成分も存在する.一方,本研究で採用したビオチン濃度はヒトにおける過剰症が生じない濃度であり,動物実験レベルでは肝機能マーカーを変動させないことが確認されている.このような安全性を踏まえると,ヒトの健康維持・増進に対しても展開可能な栄養療法として,ビオチンが利用できると考える.

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (4 results)

All 2021 2020 2019

All Presentation (3 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Presentation] ビオチンはエネルギー消費を亢進する2021

    • Author(s)
      湯浅正洋, 髙士友恵, 川邊田晃司, 石見百江, 古場一哲
    • Organizer
      日本ビタミン学会第73回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ビオチン摂取がラットのエネルギー代謝に及ぼす影響2020

    • Author(s)
      湯浅正洋, 高士友恵, 川邊田晃司, 石見百江, 古場一哲
    • Organizer
      第74回日本栄養・食糧学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Effect of dietary biotin intake on fat oxidation and body fat mass in rats.2019

    • Author(s)
      Yuasa M, Takashi T, Kawabeta K, Iwami M, Koba K.
    • Organizer
      20th ARAHE Biennial International Congress 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Book] ビタミン・バイオファクター総合事典(担当部分:2.8.5 栄養学[栄養疫学]in 2.8 ビオチン)2021

    • Author(s)
      日本ビタミン学会(担当部分の著者:湯浅正洋,渡邊敏明)
    • Total Pages
      672
    • Publisher
      朝倉書店
    • ISBN
      9784254102925
    • Related Report
      2021 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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