Synthesis of artificial cell-based incubators (microorganisms-containing artificial cells)
| Project/Area Number |
18K18157
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 62010:Life, health and medical informatics-related
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
MORITA Masamune 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (90708504)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | リポソーム / 人工細胞 / 人工細胞型インキュベータ / 生細胞-人工細胞ハイブリッド / 微生物培養 / 人工細胞型インキュベーター / 人工生体システム / 人工細胞型リアクタ |
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| Outline of Final Research Achievements |
In this study, we present a new microorganism culture systems “artificial cell-based incubators”. The method is the first step toward culturing living cells inside artificial cell-like systems. By encapsulating microorganisms at the single-cell level inside liposomes (artificial cells) and observing the single liposomes (artificial cells) under an optical microscope, we succeeded in real-time monitoring of microbial growth. Furthermore, we succeeded in demonstrating its usefulness by conducting application experiments using liposomes (artificial cells) encapsulating microorganisms.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、リポソーム（人工細胞）内での微生物培養という、材料科学分野におけるリポソームのさらなる可能性や、生物工学・バイオ産業に貢献できる可能性を示すことができた。また、この成果は、微生物がホスト細胞に共生する「細胞内共生」という真核細胞の起源モデルにボトムアップ的手法によって迫り、新たな人工微生物(生命)の創生など生物学的テーマに貢献できる点で学術・社会的意義がある。
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Report
(3 results)
Research Products
(15 results)
