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Development of an Innovative Photo-responsive Drug-Binding Balloon and Application to the Treatment of Coronary Artery Disease

Research Project

Project/Area Number 18K18382
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 90120:Biomaterials-related
Research InstitutionThe University of Tokyo

Principal Investigator

Akagi Yuki  東京大学, 大学院工学系研究科(工学部), 講師 (40782751)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsバイオマテリアル / 光機能性 / 薬剤溶出バルーン / 局所的薬剤送達システム / 冠動脈疾患 / 光応答性
Outline of Final Research Achievements

In percutaneous coronary angioplasty, one of the treatments for coronary artery disease, drug-eluting balloons(DEB) are used to prevent restenosis.The problem with current DEB is that most of the drug leaks into the bloodstream. On the other hand, the realization of our proposed system using laser will make it possible to reliably transport the drug to the affected area and to release the drug only at the affected area. During this research period, we conducted a proof-of-concept using a system using particles made of the same material as medical balloons, and confirmed that this system has retention and on/off control capabilities.

Academic Significance and Societal Importance of the Research Achievements

冠動脈疾患治療に向けた内科的療法として、体内に異物を残さない薬剤溶出バルーン(DEB)が注目されており、問題視されている薬剤漏出の解決はDEBの安全的な使用を可能にする。また、冠動脈のみならず、従来治療が困難とされてきた狭窄箇所への応用が期待できる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (10 results)

All 2021 2020 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Design of a photocleavable drug binding platform for a novel remotely controllable drug coated balloon2021

    • Author(s)
      Mizuno Hayato Laurence、Anraku Yasutaka、Sakuma Ichiro、Akagi Yuki
    • Journal Title

      Journal of Drug Delivery Science and Technology

      Volume: 62 Pages: 102375-102375

    • DOI

      10.1016/j.jddst.2021.102375

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] 冠動脈疾患治療のための薬剤内包ミセル担持型光応答性プラットフォームの開発2021

    • Author(s)
      水野隼斗, 安楽泰孝, 佐久間一郎, 赤木友紀
    • Organizer
      日本化学会第101春期年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 薬剤担持型バルーンのための血液適合性の制御された外部刺激応答性薬剤送達コーティング2019

    • Author(s)
      水野隼斗, 安楽泰孝, 佐久間一郎, 赤木友紀
    • Organizer
      第68回高分子学会年次大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 狭窄部位への高効率な薬剤送達を可能にする光応答性薬剤担持型バルーンコーティング法の開発2019

    • Author(s)
      水野隼斗, 安楽泰孝, 佐久間一郎, 赤木友紀
    • Organizer
      第58回日本生体医工学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Photoresponsive drug binding platform for enhanced local drug delivery2019

    • Author(s)
      H.L. Mizuno, Y. Anraku, I. Sakuma, Y. Akagi
    • Organizer
      UTokyo-TUM Workshop 2020
    • Related Report
      2019 Research-status Report
  • [Presentation] External Stimulation Responsive Drug Eluting Balloon for Percutaneous Transluminal Coronary Angioplasty2018

    • Author(s)
      Mizuno L H, Anraku Y, Sakuma I, Akagi Y
    • Organizer
      Biomaterials International 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 光刺激応答性薬剤担持型バルーンの開発とPEGylationによる血液適合性の向上2018

    • Author(s)
      水野隼斗, 安楽泰孝, 佐久間一郎, 赤木友紀
    • Organizer
      第67回高分子討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] Development of External Stimulation Responsive Drug Delivering Coating for Drug Eluting Balloons2018

    • Author(s)
      Mizuno L H, Anraku Y, Sakuma I, Akagi Y
    • Organizer
      先端医療シーズ開発フォーラム2019
    • Related Report
      2018 Research-status Report
  • [Presentation] Development of Light Stimulation Responsive Drug Eluting Balloon2018

    • Author(s)
      Mizuno L H, Anraku Y, Sakuma I, Akagi Y
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] 外部刺激応答性薬剤担持型バルーンへの高分子集合体の搭載2020

    • Inventor(s)
      赤木友紀、安楽泰孝、佐久間一郎、水野隼斗
    • Industrial Property Rights Holder
      赤木友紀、安楽泰孝、佐久間一郎、水野隼斗
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
    • Overseas

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Published: 2018-04-23   Modified: 2022-01-27  

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