Image indexes for facilitating to change the lifestyle for health

• Project/Area Number: 18K18453
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Studies on the Super-Aging Society
• Research Institution: Kyoto University
• Principal Investigator: Okada Tomohisa 京都大学, 医学研究科, 准教授 (30321607)
• Co-Investigator(Kenkyū-buntansha): 井上 真郷 早稲田大学, 理工学術院, 教授 (70376953)
• Project Period (FY): 2018-06-29 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 超高磁場磁気共鳴装置 / 加齢性変化 / 脳画像定量値 / 脳神経伝達物質 / 超高磁場MRI装置 / 加齢性脳変化 / 脳動脈 / 脳代謝物質 / 超高齢社会 / 生活習慣 / MR画像 / MRスペクトロスコピー / 基底核穿通枝 / 脳神経代謝物 / 深部灰白質穿通動脈枝 / 大脳皮質穿通静脈枝 / T1値 / T2*値 / QSM値 / 安静時脳機能画像 / 7テスラMRI装置 / 健康寿命 / 画像指標

Outline of Final Research Achievements

Image data was collected and analyzed mainly on the following three items using a ultra-high field MR system. In quantitative values of cerebral cortex, early changes in R2 * values were found in healthy middle-aged people. Data was collected for more than 100 subjects and analyzed. We published a speed-up method of measurement. In the analysis of deep gray matter penetrating arterial branches, an ultra-high resolution of isotropic 0.25 mm was attained, and an algorithm for image quality improvement was developed and submitted. In a study of brain neurochemicals of 140 subjects at the posterior cingulate cortex found a decrease in inhibitory neurotransmitters with aging. Furthermore, the maps of correlations between neurochemicals were different among multiple brain regions such as the dorsolateral prefrontal cortex, which was investigated for age-dependency. These MR findings are expected to elucidate early index of aging.

Academic Significance and Societal Importance of the Research Achievements

高齢者の疾病を積極的に予防して「健康寿命」を増加させることは重要である。これを阻害する要因の一つに脳卒中や認知症などの脳疾患がある。これには、神経組織とそれを栄養する細動脈の状態が大きく関与しており、肥満や喫煙等の生活習慣が関係している。早期であれば生活習慣の変更で改善できる可能性が高い。本研究の成果として脳自体の変化を客観的かつ具体的に示すことで、生活習慣を改善する意欲を大いに改善できると考えている。

Research Products

• [Int'l Joint Research] University of Pennsylvania(米国)
• [Int'l Joint Research] New York University School of Medicine(米国)
• [Journal Article] Repeatability of proton magnetic resonance spectroscopy of the brain at 7 T: effect of scan time on semi-localized by adiabatic selective refocusing and short-echo time stimulated echo acquisition mode scans and their comparison (2021)
  • Author(s): Okada Tomohisa、Kuribayashi Hideto、Kaiser Lana G.、Urushibata Yuta、Salibi Nouha、Seethamraju Ravi Teja、Ahn Sinyeob、Thuy Dinh Ha Duy、Fujimoto Koji、Isa Tadashi
  • Journal Title: Quantitative Imaging in Medicine and Surgery Volume: 11 Issue: 1 Pages: 9-20
  • DOI: 10.21037/qims-20-517
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Acceleration of 2D-MR fingerprinting by reducing the number of echoes with increased in-plane resolution: a volunteer study (2020)
  • Author(s): Yokota Y, Okada T, Fushimi Y, Yamamoto A, Nakajima S, Fujimoto K, Oshima S, Koerzdoerfer G, Nittka M, Pfeuffer J, Togashi K
  • Journal Title: MAGMA Volume: － Issue: 6 Pages: 783-791
  • DOI: 10.1007/s10334-020-00842-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Glutamate, GABA and Excitatory/Inhibitory Ratios observed by Short-TE STEAM proton MRS measurements of young healthy subjects at 7T. (2020)
  • Author(s): Okada, Tomohisa Fujimoto, Koji Thuy, Dinh Kuribayashi, Hideto Urushibata, Yuta Seethamraju, Ravi Ahn, Sinyeob Isa, Tadashi
  • Organizer: 2020 ISMRM & SMRT Virtual Conference
  • Int'l Joint Research
• [Presentation] Hippocampal concentration of glutamate: A comparative study of CEST and 1HMRS measurements at 7T. (2020)
  • Author(s): Okada, Tomohisa Nanga, Ravi Fujimoto, Koji Thuy, Dinh Reddy, Ravinder Kuribayashi, Hideto Urushibata, Yuta Seethamraju, Ravi Ahn, Sinyeob Isa, Tadashi
  • Organizer: 2020 ISMRM & SMRT Virtual Conference
  • Int'l Joint Research
• [Presentation] Comparison of T1/T2 values of white matter and deep gray matter between healthy controls and Parkinson’s disease patients using plug-and-play MRF (2020)
  • Author(s): Fujimoto, Koji Cloos, Martijn Shima, Atsushi Dinh Ha Duy, Thuy Sawamoto, Nobukatsu Takahashi, Ryosuke Isa, Tadashi Okada, Tomohisa
  • Organizer: 2020 ISMRM & SMRT Virtual Conference
  • Int'l Joint Research
• [Presentation] Age-related changes in tissue T1, T2 values of the human brain quantified by 2D PnP-MRF at 7T MRI (2019)
  • Author(s): Koji Fujimoto, Martijn A Cloos, Atsushi Shima, Dinh Ha Duy Thuy, Nobukatsu Sawamoto, Ryosuke Takahashi, Tadashi Isa, and Tomohisa Okada
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Int'l Joint Research
• [Presentation] Age-related changes in tissue T1, T2 values of the human brain quantified by 2D PnP-MRF at 7T MRI (2019)
  • Author(s): Fujimoto, Koji Cloos, Martijn Shima, Atsushi Ha Duy Thuy, Dinh Sawamoto, Nobukatsu Takahashi, Ryosuke Isa, Tadashi Okada, Tomohisa
  • Organizer: ISMRM 27th Annual Meeting and Exhibition
  • Int'l Joint Research