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Establishment of the tasty recipe with the histamine detoxification effect to prevent the allergy-like food poisoning

Research Project

Project/Area Number 18K18609
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 8:Sociology and related fields
Research InstitutionOsaka Metropolitan University (2022-2023)
Osaka City University (2018-2021)

Principal Investigator

Doe Matsumi  大阪公立大学, 事務局, 研究員 (90433317)

Co-Investigator(Kenkyū-buntansha) 森本 善樹  大阪公立大学, 大学院理学研究科, 教授 (90244631)
Project Period (FY) 2018-06-29 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsヒスタミン / 食生活 / 解毒 / アレルギー
Outline of Final Research Achievements

The study explored effective cooking methods to detoxify heat-stable histamine, traditionally managed through low-temperature storage to prevent food poisoning. Various cooking techniques, such as using an electric oven, frying, and grilling on an iron plate, led to similar high-char results. However, grilling fish on a gas stove with a ceramic component significantly reduced histamine levels by nearly 50% without much charring. Side dishes like plum extract and vinegar were also effective. Baking soda was impractical, but seasoning with sweetened plum extract or vinegar was recommended. The study concluded that grilling fish with a sweet vinegar marinade using a fish grill is the most effective method to reduce histamine levels.

Academic Significance and Societal Importance of the Research Achievements

本研究結果で、セラミック材の高温効果を利用した加熱がヒスタミン含有量低下に有意な効果を持つことが分かったことから、甘酢につけた魚肉をセラミック付き魚焼き器で加熱する調理法により、生きが良くないと感じつつ家庭で調理する際の中毒予防のレシピとして用いられることで、ヒスタミン食中毒患者の減少の一助とすることが可能となった。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (17 results)

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Journal Article] New halogenated C15 acetogenins from Okinawan sea hare Aplysia dactylomela2022

    • Author(s)
      K. Matsuyama, T. Inoue, T. Muroga, N. Arima, M. Doe, F. Tani, Y. Ookawa, Y. Okamoto, S. Onitsuka, H. Okamura, T. Iwagawa, T. Hamada
    • Journal Title

      Tetrahedron

      Volume: 120 Pages: 132889-132889

    • DOI

      10.1016/j.tet.2022.132889

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 4β-Hydroxywithanolide E and Withanolide E from Physalis peruviana L. Inhibit Adipocyte Diferentiation of 3T3-L1 Cells through Modulation of Mitotic Clonal Expansion2021

    • Author(s)
      Momoshika Kumagai, Izumi Yoshida, Takashi Mishima, Masahiro Ide, Kazuhiro Fujita, Matsumi Doe, Keisuke Nishikawa, and Yoshiki Morimoto
    • Journal Title

      J. Nat. Med.

      Volume: 75 Issue: 1 Pages: 232-239

    • DOI

      10.1007/s11418-020-01458-x

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] One‐Step Synthesis of the 1‐Azaspiro[5.5]undecane Skeleton Characteristic of Histrionicotoxin Alkaloids from Linear Substrates via Hg(OTf)<sub>2</sub>‐Catalyzed Cycloisomerization2021

    • Author(s)
      Kunihiro Matsumura, Keisuke Nishikawa, Hiroaki Yoshida, Toshiki Niwa, Yuichiro Fushii, Matsumi Doe, and Yoshiki Morimoto
    • Journal Title

      Chemistry - An Asian Journal

      Volume: 16 Issue: 14 Pages: 1882-1886

    • DOI

      10.1002/asia.202100383

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesys and biological evaluation of glucose conjugated phthalocyanine as a second-generation2019

    • Author(s)
      Yoshiyuki Uruma, Loghapriya Sivasamy, Matsumi Doe
    • Journal Title

      Bioorganic & Chemistry

      Volume: 27(15) Pages: 3279-3284

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Formal total synthesis of histrionicotoxin alkaloids via Hg(OTf)2-catalyzed cycloisomerization and SmI2-induced ring expansion2018

    • Author(s)
      Kunihiro Matsumura, Keisuke Nishikawa, Hiroaki Yoshida, Matsumi Doe, Yoshiki Morimoto
    • Journal Title

      RCS Advances

      Volume: 8(21) Pages: 11296-11303

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mass Analytcal Division, Analytical Center2018

    • Author(s)
      Matsumi Doe
    • Journal Title

      Journal of the Mass Spectrometry Society of Japan

      Volume: 66(1) Pages: 36-42

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 有機電極反応によるリグニンの効率的分解反応の開発2024

    • Author(s)
      小島翼、粳間由幸、土江松美、山田知宏、前川博史、若松寛
    • Organizer
      日本化学会 第104春季大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ESR装置群を基軸とする研究データ流通・利用エコシステムの構築2023

    • Author(s)
      佐藤和信、松岡英人、土江松美、臼杵克之助
    • Organizer
      AI等の活用を推進する研究データエコシステム構築作業シンポジウム
    • Related Report
      2023 Annual Research Report
  • [Presentation] 有機電極反応によるリグニンの効率的分解反応の開発2023

    • Author(s)
      小島翼、粳間由幸、土江松美、山田知宏、前川博史、若松寛
    • Organizer
      日本化学会 第103春季大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 光線力学療法を志向した光増感剤含有高分子ミセルの設計とNMRによるミセル化評価2023

    • Author(s)
      アルタンナヴチ バトバヤル、粳間由幸、土江松美、原望実、岡田太、Ping Shan Lai
    • Organizer
      日本化学会 第103春季大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 大学理系学部での業務展開、研究、教育2021

    • Author(s)
      土江松美
    • Organizer
      2021年度 高専女子フォーラムin中国・四国
    • Related Report
      2021 Research-status Report
  • [Presentation] 阪奈共用ネットワークにおけるJEOLハイエンドNMRリモート活用実験2020

    • Author(s)
      稲角直也、土江松美、羽子岡仁志、亀井捻之、加藤大司、中村文男、有福和紀
    • Organizer
      NMR共用プラットフォームシンポジウム2020
    • Related Report
      2020 Research-status Report
  • [Presentation] 自分で開ける扉の向こうに―科学研究の道のり―2020

    • Author(s)
      土江松美
    • Organizer
      山陰ガールズプロジェクトーリケジョによるオンラインセミナー
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Synthesis of photocytotoxicity of glucose conjugated photosensitizer2019

    • Author(s)
      Yoshiyuki Uruma, Loghapriya Sivasamy, Matsumi Doe
    • Organizer
      20th TETRAHEDRON SYMPOSIUM
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 科学研究の道のり2019

    • Author(s)
      土江松美
    • Organizer
      山陰ガールズプロジェクト;女性研究者による中高生のための講演会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] シンプルなスペクトルを考える2018

    • Author(s)
      土江松美
    • Organizer
      5大機器分析相互活用セミナー(大学連携研究設備ネットワーク自然科学研究機構主催)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 玉ねぎ中の活性成分を考える2018

    • Author(s)
      土江松美
    • Organizer
      基礎型ユーザーズミーティング(日本電子株式会社主催)
    • Related Report
      2018 Research-status Report
    • Invited

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Published: 2018-07-25   Modified: 2025-01-30  

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