| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The functions of RNA polyadenylation are diverse. In prokaryotes, polyadenylation promotes the degradation of the RNA, whereas in eukaryotes, polyadenylation inhibits the degradation of the RNA. Human mitochondrial DNA encodes 11 mRNAs and most of which are polyadenylated during maturation. We investigated the effect of polyadenyl tail shortening on mitochondrial mRNAs. Interestingly, the shortening of polyadenyl tails produced different effects on stabilization and destabilization for each mitochondrial mRNA. These results suggest that polyadenyl-tail of mitochondrial mRNAs exhibits both prokaryotic and eukaryotic polyadenyl-tail effects in each mRNA. Further studies are needed to understand the mechanism of altered stability of the mitochondrial mRNAs by polyadenyl tails.
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