Molecular mechanism for the acquisition of multipotency by ribosome
| Project/Area Number |
18K19344
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
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| Research Institution | Kumamoto University |
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Principal Investigator |
OHTA KUNIMASA 熊本大学, 大学院生命科学研究部(医), 准教授 (90244128)
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| Project Period (FY) |
2018-06-29 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | リボソーム / 多能性獲得 / リプログラミング / ヒト癌細胞 |
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| Outline of Final Research Achievements |
We tried to elucidate the molecular mechanism of cellular reprogramming byribosome. We found that ribosome was incorporated into cells by endocytosis and trypsin treatment. We also found that one of ribosome proteins have a cell cluster formation activity. When we addedribosome into the human cancer cell after trypsin treatment, some human cancer cells formed cellcluster and stopped their cell proliferation.
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| Academic Significance and Societal Importance of the Research Achievements |
正常細胞にリボソームを取り込ませると、細胞塊を形成し、増殖が停止する。ヒト癌細胞（肺癌、乳癌、大腸癌、肝臓癌）でさえ大腸菌由来リボソームを取り込むと、細胞塊を形成し、その増殖が完全に抑えられることをシャーレ内で見出している。今後は、正常細胞を用いた研究で得られた実験結果を、ヒト癌細胞にも応用することにより、ヒト癌細胞の細胞周期制御機構や細胞増殖停止機構を明らかに出来、将来の安全・安心な抗がん剤の開発に発展する可能性がある。
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation2019
Author(s)
Wang, Q., Sharma, V.P., Shen, H., Xiao, Y., Zhu, Q., Xiong, X., Guo, L., Jiang, L., Ohta, K., Li, S., Shi, H., Rui, L., and Lin, J.D
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Journal Title
Nature Metabolism
Volume: 1
Pages: 251-260
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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