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Comprehensive screening for factors that regulate age-related memory decline

Research Project

Project/Area Number 18K19370
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 46:Neuroscience and related fields
Research InstitutionChiba University

Principal Investigator

Tonoki Ayako  千葉大学, 大学院薬学研究院, 講師 (90645425)

Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords老化 / 記憶 / 加齢性記憶障害 / 可溶性グアニルシクラーゼ / NO合成酵素 / ショウジョウバエ / NOS / 遺伝
Outline of Final Research Achievements

Organisms, including humans, lose their memory as they age. Since age-related memory impairment decreases the quality of life of the elderly, elucidation of the mechanism is urgently required. In this study, genes whose expression level changes in the brain in an age-dependent manner were extracted by transcriptome analysis, and memory behavior analysis was performed using the olfactory memory system of Drosophila as a model system. A series of analyzes identified a subunit of soluble guanyl cyclase (sGC), a NO receptor, as a candidate gene for age-related memory impairment. It was suggested that the enhancement of the NO-sGC pathway in the cerebral nervous system with age causes memory decline.

Academic Significance and Societal Importance of the Research Achievements

NO-sGC経路は哺乳類でも保存されており、ヒト加齢性記憶障害を制御する候補遺伝子となり得る。またこれまでに、ハエ嗅覚記憶形成の変異体で同定された遺伝子は、ヒトを含む哺乳類でも機能的に重要であり、ヒトの記憶障害の原因解明につながった例は多い。本研究で明らかとなる加齢に伴う記憶低下の責任遺伝子群については、将来的にヒトを含む哺乳類でもその保存性を検討し、ヒトの加齢性の記億障害に対する新薬開発の候補を挙げるなど新たな治療方法へつながる基盤を提供していく。さらには、加齢性記憶障害の生体内マーカーとしての有用性に繋がることが期待される。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2020 2019 2018 2017 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (3 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Appetitive memory with survival benefit is robust across aging in Drosophila.2020

    • Author(s)
      *Tonoki A, Ogasawara M, Yu Z, Itoh M.
    • Journal Title

      J Neurosci.

      Volume: 40(11) Issue: 11 Pages: 2296-2304

    • DOI

      10.1523/jneurosci.2045-19.2020

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successive and discrete spaced conditioning in active avoidance learning in young and aged zebrafish.2017

    • Author(s)
      Yang P, Kajiwara R, Tonoki A, Itoh M.
    • Journal Title

      Neurosci Res.

      Volume: S0168-0102(17) Pages: 30502-3

    • DOI

      10.1016/j.neures.2017.10.005

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 1.NO-sGC pathway is critical for age-related memory impairment in Drosophila2020

    • Author(s)
      Ayako Tonoki〇, Saki Nagai, Zhihua Yu, Kaho Yabana, Hiroki Takahashi, Motoyuki Itoh, Ayako Tonoki
    • Organizer
      第43回日本基礎老化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] NO-sGC pathway potentially contributes to age-related memory impairment in Drosophila.2018

    • Author(s)
      Saki Nagai, Zhihua Yu, Hiroki Takahashi, Motoyuki Itoh, Ayako Tonoki
    • Organizer
      The 13th Japanese Drosophila Research Conference
    • Related Report
      2018 Research-status Report
  • [Presentation] Identification of neuropeptides regulating memory formation2018

    • Author(s)
      呂偲哲、殿城亜矢子
    • Organizer
      第11回 分子高次機能研究会
    • Related Report
      2018 Research-status Report
  • [Book] Encyclopedia of Animal Behavior2019

    • Author(s)
      Lyu, S., Tonoki, A.
    • Total Pages
      3048
    • Publisher
      Elsevier
    • ISBN
      9780128132517
    • Related Report
      2018 Research-status Report
  • [Remarks] 千葉大学薬学研究院生化学研究室ホームページ

    • URL

      http://www.p.chiba-u.jp/lab/seika/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 生化学研究室・ホームページ

    • URL

      http://www.p.chiba-u.jp/lab/seika/index.html

    • Related Report
      2018 Research-status Report

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Published: 2018-07-25   Modified: 2021-02-19  

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