Towards the development of intrapulmonary vaccine for cancer

• Project/Area Number: 18K19401
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 47:Pharmaceutical sciences and related fields
• Research Institution: Osaka University
• Principal Investigator: Yoshioka Yasuo 大阪大学, 微生物病研究所, 特任准教授(常勤) (00392308)
• Project Period (FY): 2018-06-29 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 機能性ペプチド / ワクチン / がん / 粘膜

Outline of Final Research Achievements

In the present project, we tried to develop intrapulmonary vaccine system for cancer vaccine. Although we did not reach the goal, we believe that our system will not only provide novel vaccine system for cancer but may also shed light on a novel tool for directing the biodistribution of drugs to specific cell types, such as immune cells.

Academic Significance and Societal Importance of the Research Achievements

インフルエンザに対する経鼻ワクチンは海外で既に使用されており、粘膜ワクチンによる感染症ワクチンの開発は世界規模で進められている。しかし、経肺ワクチンにより粘膜面のがんを効率的に治療しようとする発想はこれまで盲点であり、本研究を継続することで、新たな治療戦略に向けた基礎治験が得られるものと期待される。

Research Products

• [Journal Article] Murine cross-reactive non-neutralizing polyclonal IgG1 antibodies induced by influenza vaccine inhibit the cross-protective effect of IgG2 against heterologous virus in mice. (2020)
  • Author(s): Shibuya M, Aoshi T, Kuroda E, Yoshioka Y.
  • Journal Title: J Virol. Volume: - Issue: 12
  • DOI: 10.1128/jvi.00323-20
  • Peer Reviewed
• [Journal Article] Lipid Nanoparticles Potentiate CpG-Oligodeoxynucleotide-Based Vaccine for Influenza Virus (2020)
  • Author(s): Shirai S, Shibuya M, Kawai A, Tamiya S, Munakata L, Omata D, Suzuki R, Aoshi T, Yoshioka Y.
  • Journal Title: Front Immunol Volume: 10
  • DOI: 10.3389/fimmu.2019.03018
  • Peer Reviewed / Open Access
• [Journal Article] Peptides with the multibasic cleavage site of the hemagglutinin from highly pathogenic influenza viruses act as cell-penetrating via binding to heparan sulfate and neuropilins. (2019)
  • Author(s): Yamamoto Y, Tamiya S, Shibuya M, Nakase I, Yoshioka Y.
  • Journal Title: Biochem Biophys Res Commun. Volume: March 21 Issue: 3 Pages: 1-7
  • DOI: 10.1016/j.bbrc.2019.03.068
  • Peer Reviewed
• [Presentation] 1.独自創成した樹状細胞標的化ペプチドの免疫誘導メカニズムの解析 (2018)
  • Author(s): 三里一貴、金井優紀、青枝大貴、福田道子、吉岡靖雄
  • Organizer: 第34回日本DDS学会
• [Presentation] 2.Development of a cancer vaccine by using dendritic cell-targeting peptide (2018)
  • Author(s): 吉岡靖雄
  • Organizer: The 45th Naito Conference