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Animal Modeling of Hallucination and Its Neurobiological Analysis

Research Project

Project/Area Number 18K19495
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 51:Brain sciences and related fields
Research InstitutionNiigata University

Principal Investigator

Nawa Hiroyuki  新潟大学, 脳研究所, 教授 (50183083)

Project Period (FY) 2018-06-29 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords幻聴 / 幻覚 / 統合失調症 / モデル動物 / サイトカイン / 一次聴覚野 / 細胞外記録 / ファイバーフォトメトリー / 上皮成長因子 / 抗がん剤 / 聴覚皮質 / 錯聴 / 脳波 / 聴覚機能 / 事象関連電位 / 覚醒剤
Outline of Final Research Achievements

"Hallucination" may stem from a malfunction of the speech-language-auditory cognitive system, but its brain processes are shrouded in many mysteries. In this study, model animals were created and evaluated by administering epidermal growth factor receptor antibody or epidermal growth factor itself. As a result, spontaneous hyperactivity in the primary auditory cortex and its impaired signal integration with the frontal cortex were observed in the animal model prepared with epidermal growth factor but not with its receptor antibody. These results raise the hypothesis that, after exposure to the inflammatory cytokine, the auditory cortex might produce an abnormal hyperactivity with the given lack of predictive information coding from the frontal cortex, possibly resulting in auditory hallucinations.

Academic Significance and Societal Importance of the Research Achievements

幻聴や幻覚は、統合失調症や認知症において観察される代表的な病態であるが、その神経科学的メカニズムはいまだ、謎に包まれていた。本研究結果は、脳の聴覚皮質と前頭葉との情報連絡の障害は、音声文脈予測の統合異常を引き起こすため、幻聴を引き起こしているという仮説を提起する。この仮説を検証することで、当該脳疾患の治療法につながる可能性がある。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (9 results)

All 2021 2020 2019 2018

All Journal Article (3 results) (of which Open Access: 2 results,  Peer Reviewed: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Journal Article] 統合失調症モデル動物研究とその展望;幻聴の再現可能性2021

    • Author(s)
      那波宏之
    • Journal Title

      精神神経学雑誌

      Volume: 印刷中

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Perinatal Epidermal Growth Factor Signal Perturbation Results in the Series of Abnormal Auditory Oscillations and Responses Relevant to Schizophrenia2021

    • Author(s)
      Inaba Hiroyoshi、Kai Ryota、Namba Hisaaki、Sotoyama Hidekazu、Jodo Eiichi、Nin Fumiaki、Hibino Hiroshi、Yabe Hirooki、Eifuku Satoshi、Horii Arata、Nawa Hiroyuki
    • Journal Title

      Schizophrenia Bulletin Open

      Volume: 2 Issue: 1 Pages: 1-12

    • DOI

      10.1093/schizbullopen/sgaa070

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] S25-1 Mismatch negativity and frequency spectra of electrocorticogram to duration deviance in a rat model of schizophrenia2020

    • Author(s)
      Inaba Hiroyoshi、Namba Hisaaki、Sotoyama Hidekazu、Narihara Itaru、Jodo Eiichi、Yabe Hirooki、Eifuku Satoshi、Nawa Hiroyuki
    • Journal Title

      Clinical Neurophysiology

      Volume: 131 Issue: 10 Pages: e257-e257

    • DOI

      10.1016/j.clinph.2020.04.115

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Presentation] ラットを用いた精神疾患モデリングの限界と課題2021

    • Author(s)
      那波宏之
    • Organizer
      第14回ラットリソースリサーチ研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 統合失調症モデル動物研究とその展望;幻聴の再現可能性2020

    • Author(s)
      那波宏之
    • Organizer
      第116回日本精神神経学会学術総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 統合失調症患者と動物モデルに共通な聴覚生理反応異常とその評価2020

    • Author(s)
      那波 宏之, 難波 寿明, 成原 格, 外山 英和, 甲斐 竜太, 稲葉 洋芳
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 統合失調症の動物モデル化の苦難;分子生物学から神経病態生理学を用いて2019

    • Author(s)
      那波宏之
    • Organizer
      日本臨床神経生理学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Delirium-like motor behaviors induced by the negative alert voice in a rat model for schizophrenia2018

    • Author(s)
      Hiroyyuki NAWA
    • Organizer
      国際幻聴コンソーシアム京都, 京都大学、平成30年10月18日
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 幻聴・幻覚はどうして起きるのか?2018

    • Author(s)
      那波宏之
    • Organizer
      日本神経化学会若手育成セミナー
    • Related Report
      2018 Research-status Report
    • Invited

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Published: 2018-07-25   Modified: 2022-12-28  

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