Animal Modeling of Hallucination and Its Neurobiological Analysis
| Project/Area Number |
18K19495
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 51:Brain sciences and related fields
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2018-06-29 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 幻聴 / 幻覚 / 統合失調症 / モデル動物 / サイトカイン / 一次聴覚野 / 細胞外記録 / ファイバーフォトメトリー / 上皮成長因子 / 抗がん剤 / 聴覚皮質 / 錯聴 / 脳波 / 聴覚機能 / 事象関連電位 / 覚醒剤 |
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| Outline of Final Research Achievements |
"Hallucination" may stem from a malfunction of the speech-language-auditory cognitive system, but its brain processes are shrouded in many mysteries. In this study, model animals were created and evaluated by administering epidermal growth factor receptor antibody or epidermal growth factor itself. As a result, spontaneous hyperactivity in the primary auditory cortex and its impaired signal integration with the frontal cortex were observed in the animal model prepared with epidermal growth factor but not with its receptor antibody. These results raise the hypothesis that, after exposure to the inflammatory cytokine, the auditory cortex might produce an abnormal hyperactivity with the given lack of predictive information coding from the frontal cortex, possibly resulting in auditory hallucinations.
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| Academic Significance and Societal Importance of the Research Achievements |
幻聴や幻覚は、統合失調症や認知症において観察される代表的な病態であるが、その神経科学的メカニズムはいまだ、謎に包まれていた。本研究結果は、脳の聴覚皮質と前頭葉との情報連絡の障害は、音声文脈予測の統合異常を引き起こすため、幻聴を引き起こしているという仮説を提起する。この仮説を検証することで、当該脳疾患の治療法につながる可能性がある。
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Report
(4 results)
Research Products
(9 results)
