Role of the novel myokine in cardiovascular disease
Project/Area Number |
18K19541
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 53:Organ-based internal medicine and related fields
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Research Institution | Nagoya University |
Principal Investigator |
Ouchi Noriyuki 名古屋大学, 医学系研究科, 特任教授 (00595514)
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Co-Investigator(Kenkyū-buntansha) |
大橋 浩二 名古屋大学, 医学系研究科, 特任准教授 (10595515)
柴田 玲 名古屋大学, 医学系研究科, 特任教授 (70343689)
|
Project Period (FY) |
2018-06-29 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | 心血管病 / 運動 / 持久性運動 |
Outline of Final Research Achievements |
We found that the Netrin (Ntn) family member/Ntn5 acts as an exercise-inducible muscle-derived secretory factor “myokine” in mice after screening of novel myokines which are upregulated in skeletal muscle by treadmill exercise training. Intramuscular injection of adenoviral vectors expressing Ntn5 significantly enhanced blood blow recovery in a mouse model of hindlimb ischemia. Thus, Ntn5 may be a pro-angiogenic myokine induced by endurance exercise.
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Academic Significance and Societal Importance of the Research Achievements |
本研究では、持久性運動により誘発され、血管新生を促進する新たな骨格筋由来分泌因子「マイオカイン」が明らかとなった。本研究は血管新生の病態解明につながる可能性があり学術的意義は高いと考えられる。また、このマイオカインは運動による心血管保護作用にも関わり、運動すれば何故体にいいのか?という疑問に対する解決の糸口になり得る可能性があり、さらなる研究の発展も期待され、社会的意義は高いと考えられる。
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] A novel selective PPARα modulator, pemafibrate promotes ischemia-induced revascularization through the eNOS-dependent mechanisms.2020
Author(s)
Kawanishi H, Ohashi K, Ogawa H, Otaka N, Takikawa T, Fang L, Ozaki Y, Takefuji M, Murohara T, Ouchi N.
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Journal Title
PLoS One.
Volume: 15
Issue: 6
Pages: e0235362-e0235362
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Adipolin/C1q/Tnf-related protein 12 prevents adverse cardiac remodeling after myocardial infarction.2020
Author(s)
Takikawa T, Ohashi K, Ogawa H, Otaka N, Kawanishi H, Fang L, Ozaki Y, Eguchi S, Tatsumi M, Takefuji M, Murohara T, Ouchi N.
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Journal Title
PLoS One.
Volume: 15
Issue: 12
Pages: e0243483-e0243483
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cardiomyocytes capture stem cell-derived, anti-apoptotic microRNA-214 via clathrin-mediated endocytosis in acute myocardial infarction.2019
Author(s)
Eguchi S, Takefuji M, Sakaguchi T, Ishihama S, Mori Y, Tsuda T, Takikawa T, Yoshida T, Ohashi K, Shimizu Y, Hayashida R, Kondo K, Bando YK, Ouchi N, Murohara T.
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Journal Title
J Biol Chem.
Volume: 294
Issue: 31
Pages: 11665-11674
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction.2019
Author(s)
Hara A, Kobayashi H, Asai N, Saito S, Higuchi T, Kato K, Okumura T, Bando YK, Takefuji M, Mizutani Y, Miyai Y, Saito S, Maruyama S, Maeda K, Ouchi N, Nagasaka A, Miyata T, Mii S, Kioka N, Worthley DL, Murohara T, Takahashi M, Enomoto A.
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Journal Title
Circ. Res.
Volume: 125
Issue: 4
Pages: 414-430
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of Its Interaction With Actin.2019
Author(s)
Sakaguchi T, Takefuji M, Wettschureck N, Hamaguchi T, Amano M, Kato K, Tsuda T, Eguchi S, Ishihama S, Mori Y, Yura Y, Yoshida T, Unno K, Okumura T, Ishii H, Shimizu Y, Bando YK, Ohashi K, Ouchi N, Enomoto A, Offermanns S, Kaibuchi K, Murohara T.
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Journal Title
Circulation.
Volume: 140
Issue: 21
Pages: 1737-1752
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Adipolin/CTRP12 protects against pathological vascular remodeling through suppression of smooth muscle cell growth and macrophage inflammatory response.2019
Author(s)
Ogawa H, Ohashi K, Ito M, Shibata R, Kanemura N, Yuasa D, Kambara T, Matsuo K, Hayakawa S, Hiramatsu-Ito M, Otaka N, Kawanishi H, Yamaguchi S, Enomoto T, Abe T, Kaneko M, Takefuji M, Murohara T, Ouchi N.
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Journal Title
Cardiovasc Res.
Volume: in press
Issue: 1
Pages: 237-249
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury.2018
Author(s)
Otaka N, Shibata R, Ohashi K, Uemura Y, Kambara T, Enomoto T, Ogawa H, Ito M, Kawanishi H, Maruyama S, Joki Y, Fujikawa Y, Narita S, Unno K, Kawamoto Y, Murate T, Murohara T, Ouchi N.
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Journal Title
Circ Res.
Volume: 123
Issue: 12
Pages: 1326-1338
DOI
Related Report
Peer Reviewed
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