| Project/Area Number |
18K19563
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
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| Research Institution | Kyoto University |
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Principal Investigator |
Sugita Masahiko 京都大学, ウイルス・再生医科学研究所, 教授 (80333532)
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| Project Period (FY) |
2018-06-29 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | ウイルス / 免疫 / ワクチン / 細胞傷害性T細胞 / リポペプチド / MHC / 抗原提示 / 自己免疫 |
|---|
| Outline of Final Research Achievements |
Some viral proteins undergo lipid modification termed N-myristoylation to dictate their pathological function. On the other hand, host cyototoxic T-lymohocytes recognize lipopeptides derived from N-myristoylated viral proteins, thereby detecting virus-infected cells and eliminating them. In this study, we identified lipopeptide-presenting molecules in rhesus macaques and determined their fine structure. Based on these structural information, we further identified human lipopeptide-presenting molecules. These findings will advace our understanding of how virus infections are controlled and how autoimmune disorders may be elicited.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究を通して、アカゲザルならびにヒトにおけるリポペプチド提示分子の存在と機能が解明され、ウイルスリポペプチドに対する新しい細胞傷害性T細胞応答の分子機構が明らかとなりつつある。さらに、この免疫応答を再構築した小動物モデルが確立されようとしている。これらの研究成果は、今後リポペプチドワクチンという新しいタイプのワクチン開発に向けた学術的基盤の構築に寄与するとともに、社会への貢献が期待される。
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