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Construction of MRSA-specific 3D convertible DNA antibacterial drug

Research Project

Project/Area Number 18K19638
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 57:Oral science and related fields
Research InstitutionNiigata University

Principal Investigator

Terao Yutaka  新潟大学, 医歯学系, 教授 (50397717)

Co-Investigator(Kenkyū-buntansha) 中馬 吉郎  新潟大学, 自然科学系, 准教授 (40372263)
土門 久哲  新潟大学, 医歯学系, 准教授 (00594350)
前川 知樹  新潟大学, 医歯学系, 研究教授 (50625168)
米澤 大輔  新潟大学, 医歯学系, 助教 (90711896)
Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
KeywordsMRSA
Outline of Final Research Achievements

pneumonia cause 100,000 deaths among the elderly with weak immunity in Japan every year. The major causative bacteria of pneumonia are Staphylococcus aureus and Streptococcus pneumoniae. And both bacteria have advanced drug resistance. Therefore, in this study, we selected a DNA sequence that changes its shape into a cubic structure in the presence of monovalent ions. We also searched the DNA sequences for sequences that specifically bind to various proteins which express bacteriial surfaces. We then attempted to construct a DNA antibacterial drug that sterically inhibits the methicillin‐resistant Staphylococcus aureus antibacterial factor by binding to the DNA sequence in a monovalent ion-dependent manner.

Academic Significance and Societal Importance of the Research Achievements

我が国のMRSA院内感染は深刻な状況であり,現在でも年間1万人以上が死亡していると推計されている.さらに,2050年以降は世界で毎年1000万人の耐性菌による感染死者が出るとWHOが警告している.しかし,新規抗菌薬の開発は困難さから世界中で停止し,挑戦するグループは殆ど存在しない.本研究で新規のMRSA治療薬の開発研究アイデアを発信できれば,世界的な研究を誘発することもあり得る.また,MRSA治療薬の素材としてDNAを活用する着想も,国内外へ波及する可能性を秘めている.

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (65 results)

All 2020 2019 2018

All Journal Article (29 results) (of which Peer Reviewed: 29 results) Presentation (26 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Book (10 results)

  • [Journal Article] Sulfated vizantin inhibits biofilm maturation by Streptococcus mutans.2020

    • Author(s)
      Oda M, Kurosawa M, Yamamoto H, Domon H, Takenaka S, Osumi T, Maekawa T, Yamasaki N, Terao Y
    • Journal Title

      Microbiol Immunol

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Innate immune responses in serum and cerebrospinal fluid from neonates and infants infected with parechovirus-A3 or enteroviruses.2020

    • Author(s)
      Habuka R, Aizawa Y, Izumita R, Domon H, Terao Y, Takihara H, Okuda S, Saitoh A
    • Journal Title

      J Infect Dis

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of sub-minimum inhibitory concentration of chlorhexidine gluconate on development of in vitro multi-species biofilms. Biofouling.2020

    • Author(s)
      Suzuki Y, Ohsumi T, Isono T, Nagata R, Hasegawa T, Takenaka S, Terao Y, Noiri Y
    • Journal Title

      Biofouling

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Animal model of periodontitis ― Analysis of experimental ligature-induced periodontitis model in mice ―.2020

    • Author(s)
      Tamura H, Maekawa T, Hiyoshi T, Terao Y:
    • Journal Title

      Methods Mol Biol

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effect of hinokitiol against periodontal bone loss in ligature induced experimental periodontitis in mice.2020

    • Author(s)
      Hiyoshi T, Domon H, Maekawa T, Yonezawa D, Kunitomo E, Tabeta K, Terao Y
    • Journal Title

      Arch Oral Biol

      Volume: 112(4) Pages: 104679-104679

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of a novel glass ionomer cement containing flour-zinc-silicate fillers on biofilm formation and dentin ion incorporation.2020

    • Author(s)
      Hasegawa T, Takenaka S, Ohsumi T, Ida T, Ohshima H, Terao Y, Traithawit N, Maeda T, Noiri Y
    • Journal Title

      Clin Oral Investig

      Volume: 24(2) Pages: 963-970

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibacterial activity of hinokitiol against both antibiotic-resistant and -susceptible pathogenic bacteria predominant in the oral cavity and upper airways.2020

    • Author(s)
      Domon H, Hiyoshi T, Maekawa T, Yonezawa D, Tamura H, Kawabata S, Yanagihara K, Kimura O, Kunitomo E, Terao Y
    • Journal Title

      Microbiol Immunol

      Volume: 63 Pages: 213-222

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA.2019

    • Author(s)
      Yamaguchi M, Hirose Y, Takemura M, Ono M, Sumitomo T, Nakata M, Terao Y, Kawabata S
    • Journal Title

      Front Cell Infect Microbiol

      Volume: 9 Pages: 301-301

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A peptide derived from rice inhibits alveolar bone resorption via suppression of inflammatory cytokine production.2019

    • Author(s)
      Aoki-Nonaka Y, Tabeta K, Yokoji M, Matsugishi A, Matsuda Y, Takahashi N, Sulijaya B, Domon H, Terao Y, Taniguchi M, Yamazaki K
    • Journal Title

      J Periodontol

      Volume: 90(10) Pages: 1160-1169

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A horizontal sequential cutting method to estimate the effectiveness of dentin disinfection by using confocal laser scanning microscopy.2019

    • Author(s)
      Hasegawa T, Takenaka S, Wakamatsu R, Ohsumi T, Domon H, Ohshima H, Terao Y, Noiri Y
    • Journal Title

      J Endod

      Volume: 45

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin-dependent neutrophil lysis.2019

    • Author(s)
      Hiyoshi T, Domon H, Maekawa T, Nagai K, Tamura H, Takahashi N, Yonezawa D, Miyoshi T, Yoshida A, Tabeta, K, Terao Y
    • Journal Title

      Microbiol Immunol

      Volume: 63 Pages: 100-110

    • NAID

      40021899825

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children with acute otitis media in Japan from 2014 to 2017.2019

    • Author(s)
      Nagai K, Kimura O, Domon H, Maekawa T, Yonezawa D, Terao Y
    • Journal Title

      J Infect Chemother

      Volume: 25(3) Pages: 229-232

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis.2019

    • Author(s)
      Tamura H, Maekawa T, Domon H, Hiyoshi T, Yonezawa D, Nagai K, Ochiai A, Taniguchi M, Tabeta K, Maeda T, Terao Y
    • Journal Title

      Arch Oral Biol

      Volume: 98 Pages: 132-139

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection.2019

    • Author(s)
      Nagai K, Domon H, Maekawa T, Hiyoshi T, Tamura H, Yonezawa D, Habuka R, Saitoh A, Terao Y
    • Journal Title

      Vaccine

      Volume: 37 Pages: 160-168

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibacterial activity of hinokitiol against both antibiotic-resistant and -susceptible pathogenic bacteria predominant in the oral cavity and upper airways.2019

    • Author(s)
      Domon, H., Hiyoshi, T., Maekawa, T., Yonezawa, D., Tamura, H., Kawabata, S., Yanagihara, K., Kimura, O., Kunitomo, E., and Terao, Y.
    • Journal Title

      Microbiol. Immunol.

      Volume: 印刷中

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin-dependent neutrophil lysis.2019

    • Author(s)
      Hiyoshi, T., Domon, H., Maekawa, T., Nagai, K., Tamura, H., Takahashi, N., Yonezawa, D., Miyoshi, T., Yoshida, A., Tabeta, K., and Terao, Y.
    • Journal Title

      Microbiol. Immunol.

      Volume: 印刷中

    • NAID

      40021899825

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The AmyI-1-18 peptide derived from rice inhibits alveolar bone resorption via suppression of inflammatory cytokine production induced by lipopolysaccharide and interleukin-1beta.2019

    • Author(s)
      Aoki-Nonaka, Y., Tabeta, K., Yokoji, M., Matsugishi, A., Matsuda, Y., Takahashi, N., Sulijaya, B., Domon, H., Terao, Y., Taniguchi, M., and Yamazaki, K.
    • Journal Title

      J. Periodontol.

      Volume: 印刷中

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children with acute otitis media in Japan from 2014 to 2017.2019

    • Author(s)
      Nagai, K., Kimura, O., Domon, H., Maekawa, T., Yonezawa, D., and Terao, Y.
    • Journal Title

      J. Infect. Chemother.

      Volume: 25(3) Pages: 229-232

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis.2019

    • Author(s)
      Tamura, H., Maekawa, T., Domon, H., Hiyoshi, T., Yonezawa, D., Nagai, K., Ochiai, A., Taniguchi, M., Tabeta, K., Maeda, T., and Terao, Y.
    • Journal Title

      Arch. Oral Biol.

      Volume: 98 Pages: 132-139

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Repeated human deciduous tooth-derived dental pulp cell reprogramming factor transfection yields multipotent intermediate cells with enhanced iPS cell formation capability.2019

    • Author(s)
      Soda, M., Saitoh, I., Murakami, T., Inada, E., Iwase, Y., Noguchi, H., Shibasaki, S., Kurosawa, M., Sawami, T., Terunuma, M., Kubota, N., Terao, Y., Ohshima, H., Hayasaki, H., and Sato, M.
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 1490-1490

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection.2018

    • Author(s)
      Nagai, K., Domon, H., Maekawa, T., Hiyoshi, T., Tamura, H., Yonezawa, D., Habuka, R., Saitoh, A., and Terao, Y.
    • Journal Title

      Vaccine

      Volume: 37 Pages: 160-168

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanism of macrolide-induced inhibition of pneumolysin release involves impairment of autolysin release in macrolide-resistant Streptococcus pneumoniae.2018

    • Author(s)
      Domon, H., Maekawa, T., Yonezawa, D., Nagai, K., Oda, M., Yanagihara, K., and Terao, Y.
    • Journal Title

      Antimicrob. Agents Chemother.

      Volume: 62(11)

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Streptococcus pyogenes CAMP factor promotes calcium ion uptake in RAW264.7 cells.2018

    • Author(s)
      Kurosawa, M., Oda, M., Domon, H., Isono, T., Nakamura, Y., Saitoh, I., Hayasaki, H., Yamaguchi, M., Kawabata, S., and Terao, Y.
    • Journal Title

      Microbiol. Immunol.

      Volume: 62 Pages: 617-623

    • NAID

      40021702611

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neutrophil elastase subverts the immune response by cleaving toll-like receptors and cytokines in pneumococcal pneumonia.2018

    • Author(s)
      Domon, H., Nagai, K., Maekawa, T., Oda, M., Yonezawa, D., Takeda, W., Hiyoshi, T., Tamura, H., Yamaguchi, M., Kawabata, S., and Terao, Y.
    • Journal Title

      Front. Immunol.

      Volume: Vol. 9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sulfated vizantin induces the formation of macrophage extracellular traps.2018

    • Author(s)
      Oda, M., Kurosawa, M., Yamamoto, H., Domon, H., Kimura, T., Isono, T., Maekawa, T., Hayashi, N., Yamada, N., Furue, Y., Kai, D., and Terao, Y.
    • Journal Title

      Microbiol. Immunol.

      Volume: 62 Pages: 310-316

    • NAID

      40021560445

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effect of chlorhexidine on dental calculus formation: an in vitro study.2018

    • Author(s)
      Sakaue, Y., Takenaka, S., Ohsumi, T., Domon, H., Terao, Y., and Noiri, Y.
    • Journal Title

      BMC Oral Health

      Volume: 18 Pages: 52-52

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Streptococcal cysteine protease-mediated cleavage of desmogleins is involved in the pathogenesis of cutaneous infection.2018

    • Author(s)
      Sumitomo, T., Mori, Y., Nakamura, Y., Honda-Ogawa, M., Nakagawa, S., Yamaguchi, M., Matsue, H., Terao, Y., Nakata, M., and Kawabata, S.
    • Journal Title

      Front. Cell. Infect. Microbiol.

      Volume: Vol. 8

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4.2018

    • Author(s)
      Nagai, K., Domon, H., Maekawa, T., Oda, M., Hiyoshi, T., Tamura, H., Yonezawa, D., Arai, Y., Yokoji, M., Tabeta, K., Habuka, R., Saitoh, A., Yamaguchi, M., Kawabata, S., and Terao, Y.
    • Journal Title

      Cell. Immunol.

      Volume: 325 Pages: 14-22

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Streptococcus pyogenes CAMP factor promotes bacterial adhesion and invasion in pharyngeal epithelial cells without serum via PI3K/Akt signaling pathway.2018

    • Author(s)
      Kurosawa, M., Oda, M., Domon, H., Isono, T., Nakamura, Y., Saitoh, I., Hayasaki, H., Yamaguchi, M., Kawabata, S., and Terao, Y.
    • Journal Title

      Microb. Infect.

      Volume: 20 Pages: 9-18

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 新規肺炎制御法開発への展開肺炎球菌の新規治療戦略2020

    • Author(s)
      土門久哲
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Erythromycin suppresses inflammatory bone loss through reinduction of DEL-12019

    • Author(s)
      Tamura H, Maekawa T, Domon H, Hiyoshi T, Yonezawa D, Nagai K, Maeda T, Terao Y, Tabeata K
    • Organizer
      The 98th General Session of the International Association for Dental Researc
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aggregatibacter actinomycetemcomitans Leukotoxin Induce Periodontal Tissue Destruction Via Neutrophil Elastase,2019

    • Author(s)
      Hiyoshi T, Domon H, Maekawa T, Tamura H, Yonezawa D, Terao Y, Tabeta K
    • Organizer
      The 98th General Session of the International Association for Dental Researc
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新規肺炎制御法開発への展開2019

    • Author(s)
      土門久哲
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 肺炎球菌性肺炎の重症化メカニズム解析―新たな肺炎制御法の開発を目指して―2019

    • Author(s)
      土門久哲
    • Organizer
      第31回微生物シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Immunization with pneumococcal EF-Tu enhances serotype independent protection against S. pneumoniae2019

    • Author(s)
      永井康介,土門久哲,前川知樹,日吉 巧,田村 光,寺尾 豊
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Analysis of periodontal tissue destruction induced by A. actinomycetemcomitans leukotoxin2019

    • Author(s)
      日吉 巧,土門久哲,前川知樹,永井康介,田村 光,寺尾 豊
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] エリスロマイシンのDel-1再誘導による炎症性骨吸収抑制効果の検証2019

    • Author(s)
      田村 光,前川知樹,土門久哲,日吉 巧,米澤大輔,永井康介,前田健康,寺尾 豊,多部田康一
    • Organizer
      第62回春季歯周病学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Aggregatibacter actinomycetemcomitansによる歯周炎重症化メカニズムの解析2019

    • Author(s)
      日吉 巧,土門久哲,前川知樹,永井康介,田村 光,高橋直紀,吉田明弘,寺尾 豊,多部田康一
    • Organizer
      第62回春季歯周病学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] コメ由来ペプチドAmyI-1-18,アミノ酸置換体がPorphyromonas gingivalisバイオフィルムに及ぼす影響2019

    • Author(s)
      松岸 葵,野中由香莉,竹内麻衣,原 実生,土門久哲,山崎和久,多部田康一
    • Organizer
      第62回春季歯周病学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 米由来ペプチドによる炎症制御機構の検索と歯周病治療への応用研究2019

    • Author(s)
      田村 光,前川知樹,土門久哲,日吉 巧,米澤大輔,前田健康,多部田康一,寺尾 豊
    • Organizer
      新潟歯学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 宿主―細菌相互作用による肺炎重症化メカニズム解析2019

    • Author(s)
      土門久哲,永井康介,山口雅也,川端重忠,寺尾 豊
    • Organizer
      第13回細菌学若手コロッセウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] エリスロマイシンのDel-1再誘導による炎症性骨吸収抑制効果の解析2019

    • Author(s)
      田村 光,前川知樹,土門久哲,米澤大輔,前田健康,多部田康一,寺尾 豊
    • Organizer
      第7回口腔微生物研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Local regulator Del1 inhibits bone-resorption via suppression of Wnt5a-Ror2 signaling axis.2018

    • Author(s)
      Maekawa T, Domon H, Kobayashi K, Nagai K, Yonezawa D, Maeda T, Hajishengallis G, Terao Y.
    • Organizer
      The ASBMR 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 内因性抗炎症Del-1分子誘導による炎症性骨破壊の新規治療戦略2018

    • Author(s)
      前川知樹,土門久哲,田村 光,日吉 巧,寺尾 豊,前田健康
    • Organizer
      第61回秋季日本歯周病学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 口腔および上気道の病原細菌に対するヒノキチオールの抗菌作用解析2018

    • Author(s)
      土門久哲,國友栄治,寺尾 豊
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 炎症および骨吸収の制御作用を有する新規食物由来ペプチドの検索2018

    • Author(s)
      田村 光,前川知樹,土門久哲,永井康介,日吉 巧,前田健康,寺尾 豊
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Local regulator Del1 inhibits bone-resorption via suppression of Wnt5a-Ror2 signaling axis.2018

    • Author(s)
      Maekawa T, Domon H, Kobayashi K, Nagai K, Yonezawa D, Terao Y, Maeda T, Hajishengallis G.
    • Organizer
      96th General Session & Exhibition of the IADR
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 内因性抗炎症分子Del-1分子誘導による炎症性骨破壊の新規治療戦略2018

    • Author(s)
      前川知樹,小林泰浩,土門久哲,田村 光,日吉 巧,永井康介,寺尾 豊,前田健康
    • Organizer
      第4回日本骨免疫学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 食物由来ペプチドを用いた炎症と骨吸収の制御法の検索2018

    • Author(s)
      田村 光,前川知樹,米沢大輔,土門久哲,永井康介,日吉 巧,多部田康一,前田健康,寺尾 豊,吉江弘正
    • Organizer
      第61回春季日本歯周病学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Aggregatibacter actinomycetemcomitansによる歯周組織破壊メカニズムの解析2018

    • Author(s)
      日吉 巧,土門久哲,永井康介,前川知樹,高橋直紀,米沢大輔,田村 光,吉田明弘,寺尾 豊,吉江弘正
    • Organizer
      第61回春季日本歯周病学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 肺炎球菌性肺炎の重症化メカニズムの解析-新規肺炎制御法への展開-2018

    • Author(s)
      土門久哲,永井康介,前川知樹,山口雅也,川端重忠,寺尾 豊
    • Organizer
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      2018 Research-status Report
  • [Presentation] Aggregatibacter actinomycetemcomitansが産生するロイコトキシンによる歯周組織破壊メカニズムの解析2018

    • Author(s)
      日吉巧,土門久哲,永井康介,前川知樹,高橋直紀,米澤大輔,田村光,吉田明弘,寺尾 豊
    • Organizer
      第6回五大学・口腔微生物研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 肺炎球菌とマクロライド:新潟市内の耐性菌分離率と病原性抑制作用の解析2018

    • Author(s)
      土門久哲,前川知樹,永井康介,栁原克紀,木村 征,寺尾 豊
    • Organizer
      第57回新潟化学療法研究会学術講演会
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      2018 Research-status Report
  • [Presentation] マクロライド耐性肺炎球菌に対するマクロライド系抗菌薬の作用解析2018

    • Author(s)
      土門久哲,前川知樹,永井康介,栁原克紀,木村 征,寺尾 豊
    • Organizer
      第25回マクロライド新作用研究会
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      2018 Research-status Report
  • [Presentation] 内因性抗炎症分子Del-1を介したマクロライド系抗菌薬の新作用機序2018

    • Author(s)
      前川知樹,土門久哲,寺尾 豊
    • Organizer
      第25回マクロライド新作用研究会
    • Related Report
      2018 Research-status Report
  • [Book] 新版 歯学生のための摂食嚥下リハビリテーション学2020

    • Author(s)
      寺尾 豊(分担執筆)
    • Total Pages
      291
    • Publisher
      医歯薬出版
    • Related Report
      2019 Annual Research Report
  • [Book] 口腔微生物学・免疫学 第4版第5刷2020

    • Author(s)
      寺尾 豊(分担執筆)
    • Total Pages
      303
    • Publisher
      医歯薬出版
    • Related Report
      2019 Annual Research Report
  • [Book] 歯科衛生士書き込み式学習ノート?@ 専門基礎科目編 第2版第2刷2020

    • Author(s)
      寺尾 豊(分担執筆)
    • Total Pages
      301
    • Publisher
      医歯薬出版
    • Related Report
      2019 Annual Research Report
  • [Book] パーフェクトマスター口腔微生物学・免疫学 改訂増刷版2020

    • Author(s)
      寺尾 豊
    • Total Pages
      93
    • Publisher
      医歯薬出版
    • Related Report
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  • [Book] Update on the Immune Mechanisms Against Respiratory Pathogens2019

    • Author(s)
      Domon H, Nagai K, Maekawa T, Oda M, Yonezawa D, Takeda W, Hiyoshi T, Tamura H, Yamaguchi M, Kawabata S, Terao Y
    • Total Pages
      355
    • Publisher
      Frontiers e-book
    • Related Report
      2019 Annual Research Report
  • [Book] 日本歯科評論:米ペプチドを用いた歯槽骨吸収の抑制2019

    • Author(s)
      寺尾 豊
    • Total Pages
      190
    • Publisher
      ヒョーロン・パブリッシャーズ社
    • Related Report
      2018 Research-status Report
  • [Book] 日本歯科評論:誤嚥性肺炎の分子制御に向けて2019

    • Author(s)
      寺尾 豊
    • Total Pages
      182
    • Publisher
      ヒョーロン・パブリッシャーズ社
    • Related Report
      2018 Research-status Report
  • [Book] 日本歯科評論:歯周病における歯肉細胞損傷メカニズムとその制御研究2019

    • Author(s)
      寺尾 豊
    • Publisher
      ヒョーロン・パブリッシャーズ社
    • Related Report
      2018 Research-status Report
  • [Book] パーフェクトマスター口腔微生物学・免疫学2018

    • Author(s)
      寺尾 豊
    • Total Pages
      93
    • Publisher
      医歯薬出版
    • Related Report
      2018 Research-status Report
  • [Book] 微生物学,歯科衛生士 歯科衛生士書き込み式学習ノート①2018

    • Author(s)
      寺尾 豊
    • Total Pages
      298
    • Publisher
      医歯薬出版
    • Related Report
      2018 Research-status Report

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Published: 2018-07-25   Modified: 2021-02-19  

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