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Ideal nasal microbiome for the treatment of sublingual immunotherapy of Japanese cedar by machine learning

Research Project

Project/Area Number 18K19734
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research InstitutionUniversity of Fukui

Principal Investigator

Fujieda Shigeharu  福井大学, 学術研究院医学系部門, 教授 (30238539)

Co-Investigator(Kenkyū-buntansha) 二之宮 貴裕  福井大学, 学術研究院医学系部門, 特別研究員 (30796199)
野口 恵美子  筑波大学, 医学医療系, 教授 (40344882)
Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords花粉症 / 舌下免疫療法 / 細菌叢 / マイクロバイオーム / 花粉症治療 / 善玉菌 / スギ花粉症 / 鼻腔内細菌叢 / 嫌気性菌 / バイオマーカー / 機械学習 / アレルギー学 / 鼻科学
Outline of Final Research Achievements

Nasal microbiome was performed in the 105 Japanese cedar pollinosis patients treated with sublingual immunotherapy (SLIT) by 16S rRNA sequencing. At phylum level, nasal microbiome was composed of Firmicutes, Bacteroidetes, Proteobacteria, Unclassified, Fusobacteria, Actinobacteria, followed by others, suggesting that Firmicutes, Bacteroidetes, and Proteobacteria are three major phyla in Japanese. The composition ratio of two types of anaerobic bacteria was significantly higher in asymptomatic patients as compared with symptomatic patients after SLIT. These results showed that two types of anaerobic bacteria in the nose may be the probiotics for allergic rhinitis.

Academic Significance and Societal Importance of the Research Achievements

2種類の嫌気性菌が、鼻内善玉菌であることが判明した。このことはこの2種類の菌を使った細菌カクテルの重要な成分であることを示している。しかしこれらが、どのような作用によって舌下免疫療法に相乗的な効果を認めるのかは、現在は不明である。これまで衛生仮説によって、TLR刺激が舌下免疫療法の治療効果に影響を及ぼすのかも知れないが、今後も検討していく必要がある。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2020 2019 2018

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] Epidemiological study of oral allergy syndrome in birch pollen dispersal-free regions2020

    • Author(s)
      Osawa Y, Ito Y, Fujieda S, et al.
    • Journal Title

      Allergology International

      Volume: 69 Issue: 2 Pages: 246-252

    • DOI

      10.1016/j.alit.2019.09.008

    • NAID

      130007832960

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety profile and immunological response of dual sublingual immunotherapy with house dust mite tablet and Japanese cedar pollen tablet2020

    • Author(s)
      Gotoh M, Okubo K, Fujieda S, et al
    • Journal Title

      Allergology International

      Volume: 69 Issue: 1 Pages: 104-110

    • DOI

      10.1016/j.alit.2019.07.007

    • NAID

      130007788693

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of house dust mite sublingual tablet in the treatment of allergic rhinoconjunctivitis: A randomized trial in a pediatric population.2019

    • Author(s)
      Okamoto Y, Fujieda S, Okano M, Hida H, Kakudo S, Masuyama K.
    • Journal Title

      Pediatr Allergy Immunol.

      Volume: 30 Issue: 1 Pages: 66-73

    • DOI

      10.1111/pai.12984

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combination therapy with montelukast and loratadine alleviates pharyngolaryngeal symptoms related to seasonal allergic rhinitis.2019

    • Author(s)
      Imoto Y, Takabayashi T, Sakashita M, Tokunaga T, Morikawa T, Ninomiya T, Okamoto M, Narita N, Fujieda S.
    • Journal Title

      J Allergy Clin Immunol Pract.

      Volume: 7 Issue: 3 Pages: 1068-1070

    • DOI

      10.1016/j.jaip.2018.07.034

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] ALLERGIC RHINITIS・CHRONIC RHINOSINUSITIS2018

    • Author(s)
      Fujieda S, Kato Y, Ninomiya T.
    • Journal Title

      Japanese Journal of Allergology

      Volume: 67 Issue: 10 Pages: 1379-1386

    • DOI

      10.15036/arerugi.67.1379

    • NAID

      130007529847

    • ISSN
      0021-4884, 1347-7935
    • Related Report
      2018 Research-status Report
  • [Journal Article] MECHANISMS OF ALLERGEN IMMUNOTHERAPY FOR INHALED ALLERGENS AND CLINICAL BIOMARKERS2018

    • Author(s)
      Sakashita M, Fujieda S.
    • Journal Title

      Japanese Journal of Allergology

      Volume: 67 Issue: 8 Pages: 987-994

    • DOI

      10.15036/arerugi.67.987

    • NAID

      130007490261

    • ISSN
      0021-4884, 1347-7935
    • Related Report
      2018 Research-status Report
  • [Presentation] アレルギー性鼻炎の先制医療2019

    • Author(s)
      藤枝重治
    • Organizer
      第1回日本アレルギー学会中国・四国地方部会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] アレルギー性鼻炎の先制医療2019

    • Author(s)
      藤枝重治
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Research-status Report

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Published: 2018-07-25   Modified: 2021-02-19  

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