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Establishment of sarcopenia obesity-model animal and elucidation of its pathophysiology

Research Project

Project/Area Number 18K19743
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research InstitutionHiroshima University

Principal Investigator

Ukena Kazuyoshi  広島大学, 統合生命科学研究科(総), 教授 (10304370)

Co-Investigator(Kenkyū-buntansha) 岩越 栄子  広島大学, 統合生命科学研究科(総), 研究員 (50311296)
長谷川 博  広島大学, 人間社会科学研究科(総), 教授 (70314713)
Project Period (FY) 2018-06-29 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords視床下部 / 小タンパク質 / 脂肪蓄積 / 筋肉 / 成長 / 骨長 / サルコペニア / 肥満 / 神経ペプチド
Outline of Final Research Achievements

We have discovered a novel secretory small protein, NPGL, in the hypothalamus. It has been found that NPGL stimulates feeding behavior and induces fat accumulation in the white adipose tissue, although the weight gain is not remarkable, and the cause is a decrease in bone length and the mass of skeletal muscle. Recently, attention has been focused on sarcopenia obesity, which increases fat and decreases muscle. Therefore, in this research, we considered that it is possible to produce model animals exhibiting sarcopenia obesity-like state by effectively utilizing the physiological function of NPGL. As a result of various NPGL gene overexpression and NPGL administration using mice and rats, it was found that rats overexpressed using an adeno-associated virus vector are suitable as sarcopenia-like model animals.

Academic Significance and Societal Importance of the Research Achievements

近年、筋肉量の減少(サルコペニア)と肥満が組み合わさった状態であるサルコペニア肥満の増加が問題となっている。我々が独自に見出した因子であるNPGLの作用を亢進した動物は、短期間でサルコペニア肥満を模倣している可能性あり、これまで未解明であったサルコペニア肥満の病態解明を行う上で貴重なモデル動物に成り得ると考えている。そのため、リハビリテーション科学、スポーツ科学、体育、栄養学、健康科学の幅広い分野において重要な科学的知見を加える可能性を示すことができたことから、学術的及び社会的意義は極めて大きい。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (18 results)

All 2022 2021 2020 2019

All Journal Article (15 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 15 results,  Open Access: 12 results) Presentation (3 results) (of which Invited: 2 results)

  • [Journal Article] Hypothalamic Overexpression of Neurosecretory Protein GL Leads to Obesity in Male C57BL/6J Mice2022

    • Author(s)
      Narimatsu Yuki、Iwakoshi-Ukena Eiko、Fukumura Keisuke、Shikano Kenshiro、Furumitsu Megumi、Morishita Masahiro、Bentley George E.、Kriegsfeld Lance J.、Ukena Kazuyoshi
    • Journal Title

      Neuroendocrinology

      Volume: - Issue: 6 Pages: 606-620

    • DOI

      10.1159/000518969

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Advancing reproductive neuroendocrinology through research on the regulation of GnIH and on its diverse actions on reproductive physiology and behavior2022

    • Author(s)
      Tsutsui Kazuyoshi、Ubuka Takayoshi、Ukena Kazuyoshi
    • Journal Title

      Frontiers in Neuroendocrinology

      Volume: 64 Pages: 100955-100955

    • DOI

      10.1016/j.yfrne.2021.100955

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical Analysis of Neurotransmitters in Neurosecretory Protein GL-Producing Neurons of the Mouse Hypothalamus2022

    • Author(s)
      Naito Mana、Iwakoshi-Ukena Eiko、Moriwaki Shogo、Narimatsu Yuki、Kato Masaki、Furumitsu Megumi、Miyamoto Yuta、Esumi Shigeyuki、Ukena Kazuyoshi
    • Journal Title

      Biomedicines

      Volume: 10 Issue: 2 Pages: 454-454

    • DOI

      10.3390/biomedicines10020454

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neurosecretory Protein GL Accelerates Liver Steatosis in Mice Fed Medium-Fat/Medium-Fructose Diet2022

    • Author(s)
      Narimatsu Yuki、Iwakoshi-Ukena Eiko、Naito Mana、Moriwaki Shogo、Furumitsu Megumi、Ukena Kazuyoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 4 Pages: 2071-2071

    • DOI

      10.3390/ijms23042071

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Stressors on the mRNA Expressions of Neurosecretory Protein GL and Neurosecretory Protein GM in Chicks2022

    • Author(s)
      Kato Masaki、Iwakoshi-Ukena Eiko、Narimatsu Yuki、Furumitsu Megumi、Ukena Kazuyoshi
    • Journal Title

      Frontiers in Physiology

      Volume: 13 Pages: 860912-860912

    • DOI

      10.3389/fphys.2022.860912

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Irregular Feeding on the Daily Fluctuations in mRNA Expression of the Neurosecretory Protein GL and Neurosecretory Protein GM Genes in the Mouse Hypothalamus2021

    • Author(s)
      Kadota Atsuki、Iwakoshi-Ukena Eiko、Fukumura Keisuke、Shikano Kenshiro、Narimatsu Yuki、Furumitsu Megumi、Ukena Kazuyoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 4 Pages: 2109-2109

    • DOI

      10.3390/ijms22042109

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adrenomedullin 2 and 5 activate the calcitonin receptor-like receptor (clr) – Receptor activity-modifying protein 3 (ramp3) receptor complex in Xenopus tropicalis2021

    • Author(s)
      Ogoshi M, Takahashi M, Aoyagi K, Ukena K, Aizawa S, Takeuchi H, Takahashi S, Takeuchi S.
    • Journal Title

      Gen Comp Endocrinol.

      Volume: 306 Pages: 113752-113752

    • DOI

      10.1016/j.ygcen.2021.113752

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of neurosecretory protein GL on food intake and fat accumulation under different dietary nutrient compositions in rats2021

    • Author(s)
      Fukumura Keisuke、Shikano Kenshiro、Narimatsu Yuaki、Iwakoshi-Ukena Eiko、Furumitsu Megumi、Naito Mana、Ukena Kazuyoshi
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: zbab064 Issue: 6 Pages: 1514-1520

    • DOI

      10.1093/bbb/zbab064

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Overexpression of Neurosecretory Protein GL-Precursor Gene on Glucose Homeostasis and Insulin Sensitivity in Mice2021

    • Author(s)
      Fukumura Keisuke、Narimatsu Yuki、Moriwaki Shogo、Iwakoshi-Ukena Eiko、Furumitsu Megumi、Ukena Kazuyoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 9 Pages: 4681-4681

    • DOI

      10.3390/ijms22094681

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Subcutaneous infusion of neurosecretory protein GL promotes fat accumulation in mice2021

    • Author(s)
      Narimatsu Yuki、Fukumura Keisuke、Iwakoshi-Ukena Eiko、Mimura Ayaka、Furumitsu Megumi、Ukena Kazuyoshi
    • Journal Title

      Heliyon

      Volume: 7 Issue: 7 Pages: e07502-e07502

    • DOI

      10.1016/j.heliyon.2021.e07502

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of the Gene Encoding Neurosecretory Protein GL Precursor Prevents Excessive Fat Accumulation in the Adipose Tissue of Mice Fed a Long-Term High-Fat Diet2021

    • Author(s)
      Fukumura Keisuke、Narimatsu Yuki、Moriwaki Shogo、Iwakoshi-Ukena Eiko、Furumitsu Megumi、Ukena Kazuyoshi
    • Journal Title

      Molecules

      Volume: 26 Issue: 19 Pages: 6006-6006

    • DOI

      10.3390/molecules26196006

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel Hypothalamic Factor, Neurosecretory Protein GM, Causes Fat Deposition in Chicks2021

    • Author(s)
      Kato Masaki、Iwakoshi-Ukena Eiko、Furumitsu Megumi、Ukena Kazuyoshi
    • Journal Title

      Frontiers in Physiology

      Volume: 12 Pages: 747473-747473

    • DOI

      10.3389/fphys.2021.747473

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Chronic Intracerebroventricular Infusion of RFamide-Related Peptide-3 on Energy Metabolism in Male Mice2020

    • Author(s)
      Moriwaki Shogo、Narimatsu Yuki、Fukumura Keisuke、Iwakoshi-Ukena Eiko、Furumitsu Megumi、Ukena Kazuyoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 22 Pages: 8606-8606

    • DOI

      10.3390/ijms21228606

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurosecretory protein GL induces fat accumulation in mice.2020

    • Author(s)
      Shikano K, Iwakoshi-Ukena E, Saito T, Narimatsu Y, Kadota A, Furumitsu M, Bentley GE, Kriegsfeld LJ, Ukena K.
    • Journal Title

      J. Endocrinol.

      Volume: 244 Issue: 1 Pages: 1-12

    • DOI

      10.1530/joe-19-0112

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neurosecretory protein GL induces fat accumulation in chicks.2019

    • Author(s)
      Shikano K, Iwakoshi-Ukena E, Kato M, Furumitsu M, Bentley GE, Kriegsfeld LJ, Ukena K.
    • Journal Title

      Front. Endocrinol.

      Volume: 10 Pages: 392-392

    • DOI

      10.3389/fendo.2019.00392

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 新規神経分泌因子の発見とその機能2021

    • Author(s)
      浮穴和義
    • Organizer
      第126回日本解剖学会総会・全国学術集会/第98回日本生理学会大会合同大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 視床下部分泌性小タンパク質の脂肪蓄積作用2020

    • Author(s)
      福村圭介、成松勇樹、鹿野健史朗、齋藤鷹也、近藤邦裕、 古満芽久美、岩越栄子、浮穴和義
    • Organizer
      第5回食欲・食嗜好の分子・神経基盤研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] 新規視床下部因子によるエネルギー代謝調節 ―脳と食欲・脂肪・筋肉との関係に着目して―2019

    • Author(s)
      浮穴和義
    • Organizer
      第27回日本運動生理学会大会
    • Related Report
      2019 Research-status Report
    • Invited

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Published: 2018-07-25   Modified: 2023-01-30  

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