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Creation of novel regenerative therapy based on the platelets of natural drug targeting carrier

Research Project

Project/Area Number 18K19919
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionKyoto University

Principal Investigator

Tabata Yasuhiko  京都大学, ウイルス・再生医科学研究所, 教授 (50211371)

Co-Investigator(Kenkyū-buntansha) 城 潤一郎  京都大学, ウイルス・再生医科学研究所, 助教 (60511243)
Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords血小板 / 再生治療 / 炎症ターケティングキャリア / 体内細胞動員 / 組織幹細胞 / 炎症ターゲティングキャリア
Outline of Final Research Achievements

Poly(lactic acid) microspheres were prepared and coated with gelatin, gelatin derivatives, and poly(vinyl alcohol). When applied to platelets which had been isolated from rabbit blood, the microspheres were taken up by the platelets, irrespective of the coated type. The platelets were treated with fibrin. As expected, the microspheres were excreted from the platelets. Following the incubation with platelets, the microspheres incorporating an anti-tumor drug were taken up by the platelets to a similar extent. The fibrin treatment allowed the microspheres to extract from platelets while the drug in microspheres extracted remained the biological activity.

Academic Significance and Societal Importance of the Research Achievements

本研究の目的は、血小板本来のもつ炎症部位への集積機能を活用した革新的治療技術の創生である。血小板は、物質を取り込み、フィブリンなどの刺激により取り込んだ物質をはき出す性質をもっている。本研究では、血小板への薬物取り込みを向上させるために、薬物を高分子粒子キャリアに包含する。薬物を取り込んだ血小板を血液中に投与すると血小板は炎症部位へと自然と集積される(天然ターゲティング)。炎症部位に存在するフィブリンにより、炎症部位で血小板から薬物は放出される。この天然の血小板の性質を利用した薬物デリバリーシステムは、今後の治療概念に大きな変革をもたらすと考えられる。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2019 2018

All Presentation (3 results) (of which Invited: 2 results)

  • [Presentation] Drug Delivery System of Biomaterial Technology Necessary for Life Sciences.2019

    • Author(s)
      田畑泰彦
    • Organizer
      Okinawa Colloids2019、沖縄
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 臨床家に役立つ再生医療の実際2019

    • Author(s)
      田畑泰彦
    • Organizer
      第49回日本創傷治癒学会教育講演、埼玉県
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 抗がん剤含有高分子ナノ粒子-血小板ハイブリッドDDSのデザイン2018

    • Author(s)
      城潤一郎、明石祐典、田畑泰彦
    • Organizer
      第40回日本バイオマテリアル学会大会、神戸
    • Related Report
      2018 Research-status Report

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Published: 2018-07-25   Modified: 2021-02-19  

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