| Project/Area Number |
18K19938
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
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| Research Institution | Keio University |
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Principal Investigator |
Nagase Kenichi 慶應義塾大学, 薬学部(芝共立), 准教授 (10439838)
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| Co-Investigator(Kenkyū-buntansha) |
金澤 秀子 慶應義塾大学, 薬学部(芝共立), 教授 (10240996)
綾野 絵理 慶應義塾大学, 薬学部(芝共立), 研究員 (10424102)
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| Project Period (FY) |
2018-06-29 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | バイオマテリアル / 再生医療 / 組織工学 / DDS / 細胞組織 / ナノ粒子 / 酸素 / 虚血 / 細胞移植 / 酸素産生 / 組織生着 |
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| Outline of Final Research Achievements |
In the present study, we developed nano-particles composed of polylactic acid-polyglycolic acid (PLGA) were developed. Electrospray method was used for preparation of nano-particles. Diameter, and configuration of nanoparticles were modulated by changing the applied voltage and composition of PLGA solution. The developed nanoparticles have potency for increased cellular function after transplantation with cellular tissue.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究課題で開発したナノ粒子は、細胞を移植して疾病を治療する再生医療において、疾患部位に移植した細胞の生存率、活性を向上できる可能性がある。これにより、再生医療の治療効果の向上、および、その適用範囲を大幅に拡大できる可能性がある。
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