Development of multi-llayer cell stretching devices
| Project/Area Number |
18K19946
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
NAKANISHI Jun 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, グループリーダー (60360608)
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| Project Period (FY) |
2018-06-29 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | メカノバイオロジー / 細胞伸展 / アゾベンゼン / ハイドロゲル / 伸縮 / 細胞骨格 / 接着斑 / 光異性化 / ストレッチング |
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| Outline of Final Research Achievements |
In our living body, many cells are exposed to stretching stimuli, whose physiological functions are yet-to-be determined. In this study, we have developed a functional hydrogel, which can be swollen and shrunk in response to photoirradiation, in order to apply arbitral stretching stimuli to cells. During this research period, we have successfully developed such functional hydrogel and succeeded culturing cells thereon. This device will be useful to investigate cellular responses against mechanical stretching of various scales.
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| Academic Significance and Societal Importance of the Research Achievements |
管腔組織を構成する細胞は，普段の活動で伸縮刺激を受けて機能調節を受けているが，その詳細な理解は，高血圧や頻尿などの加齢とともに増加する疾患への治療戦略に指針を与える。本研究で開発した光応答デバイスでは，細胞内に存在する様々なスケールの生体分子装置の伸展刺激に対する影響を調べることができるようになる。それ故，基礎的な側面での機構解明に加え，薬剤スクリーニングなどの応用面でも期待される。
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Report
(3 results)
Research Products
(7 results)
