Mechanisms of retrotransposon accumulation in age-related macular degeneration
Project/Area Number |
18K19961
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Research Category |
Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
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Allocation Type | Multi-year Fund |
Review Section |
Biological Sciences
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥61,620,000 (Direct Cost: ¥47,400,000、Indirect Cost: ¥14,220,000)
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Keywords | 逆転写 / Alu / 加齢黄斑変性 / cDNA / レトロトランスポゾン / DNA蓄積 / 黄斑変性 / 黄斑変性症 / TREX1遺伝子欠損 |
Outline of Final Research Achievements |
Dry type age-related macular degeneration is a disease that causes serious vision loss with age. We started an independent laboratory, the Laboratory of Advanced Vision Science , at the University of Tsukuba, and has demonstrated that Alu RNA accumulates in the retinal pigment epithelium of patients with dry type age-related macular degeneration through a mechanism very similar to aging. And Alu cDNA is generated by reverse transcription, inducing retinal pigment epithelial cell death. The results were reported in PNAS and Science Advanced as the first author (Fukuda S, PNAS 2021; FukudaS Sci Adv 2021).
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Academic Significance and Societal Importance of the Research Achievements |
萎縮型加齢黄斑変性は、加齢とともに深刻な視力の低下を引き起こす疾患であり、現在有効な治療法はない。本研究成果は、新しい遺伝情報の流れを見出し、萎縮型加齢黄斑変性のメカニズムの一端を解明、逆転写を阻害する事が萎縮型加齢黄斑変性の悪化の予防に繋がる可能性を示唆した。
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Report
(5 results)
Research Products
(25 results)
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[Journal Article] Subretinal injection in mice to study retinal physiology and disease.2022
Author(s)
Huang P, Narendran S, Pereira F, Fukuda S, Nagasaka Y, Apicella I, Yerramothu P, Marion K, Cai X, Sadda S, Gelfand B, Ambati J.
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Journal Title
Nature Protocols
Volume: in press
Issue: 6
Pages: 1468-1485
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The Learning Curve of Murine Subretinal Injection Among Clinically Trained Ophthalmic Surgeons2022
Author(s)
Huang P, Narendran S, Pereira F, Fukuda S, Nagasaka Y, Apicella I, Yerramothu P, Marion K, Cai X, Sadda S, Gelfand B, Ambati J.
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Journal Title
Transl Vis Sci Technol .
Volume: 11
Issue: 3
Pages: 13-13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Label-free metabolic imaging of non-alcoholic-fatty-liver-disease (NAFLD) liver by volumetric dynamic optical coherence tomography.2022
Author(s)
Mukherjee P, Fukuda S, Lukmanto D, Yamashita T, Okada K, Makita S, El-Sadek IA, Arata Miyazawa, Zhu L, Morishita R, Lichtenegger A, Oshika T, Yasuno Y.
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Journal Title
Biomed Opt Express.
Volume: 13
Issue: 7
Pages: 4071-4086
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration2021
Author(s)
Narendran S, Pereira F, Yerramothu P, Apicella I, Wang S, Ambati K, Hirahara S, Kim Y, Ambati M, Ambati V, Huang P, Varshney A, Nagasaka Y, Fukuda S, Baker K, Marion K, Deussing J, Sadda S, Gelfand B, and Ambati J.
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Journal Title
Signal Transduct Target Ther
Volume: 6
Issue: 1
Pages: 149-149
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development.2020
Author(s)
Ambati J, Magagnoli J, Leung H, Wang S, Andrews C, Fu D, Pandey A, Sahu S, Narendran S, Hirahara S, Fukuda S, Sun J, Pandya L, Ambati M, Pereira F, Varshney A, Cumimngs T, Hardin J, Edun B, Bennett C, Ambati K, Fowler B, Kerur N, Rover C, Leitinger N, Werner B, Sutton S, Gelfand B.
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Journal Title
Nature Communications
Volume: 11
Issue: 1
Pages: 4737-4737
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Chronic Dicerl Deficiency Promotes Atrophic and Neovascular Outer Retinal Pathologies in Mice2020
Author(s)
Wright CB, Uehara H, Kim Y, Yasuma T, Yasuma R, Hirahara S, Makin RD, Apicella I, Pereira F, Nagasaka Y, Narendran S, Fukuda S, Albuquerque R, Fowler BJ, Bastos-Carvalho A, Georgel P, Hatada I, Chang B, Kerur N, Ambati BK, Ambati J, Gelfand BD.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 117
Issue: 5
Pages: 2579-2587
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Quantification of ex-vivo tissue activity by polarization dynamics imaging using Jones matrix optical coherence tomography2020
Author(s)
Mukherjee P, Miyazawa A, Shen L, Fukuda S, Yamashita T, Oka Y, E1-Sadek IA, Makita S, Matsusaka S, Oshika T, Kano H, Yasuno Y
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Journal Title
DOI
Related Report
Peer Reviewed
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