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Development of a new diagnostic and therapeutic platform for swine Streptococcus infections to prevent the emergence of drug-resistant strains.

Research Project

Project/Area Number 18KK0193
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 42:Veterinary medical science, animal science, and related fields
Research InstitutionKyoto University

Principal Investigator

Nakagawa Ichiro  京都大学, 医学研究科, 教授 (70294113)

Co-Investigator(Kenkyū-buntansha) 遠矢 真理  順天堂大学, 医学部, 助教 (20804694)
関崎 勉  東京大学, 大学院農学生命科学研究科(農学部), 教授 (70355163)
相川 知宏  京都大学, 医学研究科, 助教 (70725499)
Project Period (FY) 2018-10-09 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2021: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsブタレンサ球菌 / 抗体 / 人工抗体 / 抗原同定 / タイ / ベトナム / Streptocuccus suis / 強毒株 / 菌体表層分子 / ワクチン抗原 / 抗原 / ブタ血清 / 単分子抗体 / 質量分析 / 豚レンサ球菌 / 血清 / IgG / 薬剤耐性 / ファージディスプレイ
Outline of Final Research Achievements

In this study, we will focus on antibodies induced in pig saliva and serum in Japan, Thailand, and Vietnam, using the genomic analysis information and pathogenic gene information to identify antigen molecules of S. suis recognized by the antibodies. Artificial fragment antibodies particular to the antigen obtained select artificial antibodies obtained from the phage display library. Using these antibodies, we will design optimal binding regions for binding to S. suis antigens and establish a drug discovery platform to obtain antibodies with a high binding capacity to various antigens. We also try to create therapeutic antibodies for IVIG and develop the most effective antibodies. This project aims to generate antibodies for diagnosing S. suis infection, standardization of antibodies for diagnosing S. suis infection, and identification of the most influential vaccine antigens.

Academic Significance and Societal Importance of the Research Achievements

これまでブタレンサ球菌株での高病原性を示す菌株に特異的な抗原は明らかとされていなかったが、本研究によりS. suisの表層抗原のうち、高病原株に特異的な抗原を3種類同定することができた。また、これらの抗原に対する人工低分子化抗体の作製を試みたところ、その取得に成功し、これらの人工抗体は菌の付着を優位に減少させることが明らかとなった。この結果は、これまで未知であったS. suis感染に対する診断用抗体の作製や、診断用抗体として使用することが期待できる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (57 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (4 results) Journal Article (23 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 23 results,  Open Access: 19 results) Presentation (26 results) (of which Invited: 9 results) Remarks (4 results)

  • [Int'l Joint Research] カセサート大学(タイ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] ノンラム大学(ベトナム)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] カセサート大学(タイ)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ノンラム大学(ベトナム)

    • Related Report
      2018 Research-status Report
  • [Journal Article] FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan2021

    • Author(s)
      Yamada Akihiro、Hikichi Miyako、Nozawa Takashi、Nakagawa Ichiro
    • Journal Title

      EMBO reports

      Volume: 22 Issue: 11

    • DOI

      10.15252/embr.202152584

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of a putative maltodextrin-binding protein of Streptococcus pyogenes, SPs0871 and the development of a VHH inhibitor2021

    • Author(s)
      Yamawaki T, Nakakido M, Ujiie K, Aikawa C, Nakagawa I, Tsumoto K
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 6 Pages: 1-7

    • DOI

      10.1016/j.bbrc.2021.05.056

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single-chain variable fragment (scFv) targeting streptolysin O controls group A Streptococcus infection.2021

    • Author(s)
      Aikawa C, Kawashima K, Fukuzaki C, Nakakido M, Murase K, Nozawa T, Tsumoto K, Nakagawa I
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 20 Pages: 177-183

    • DOI

      10.1016/j.bbrc.2021.06.021

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Patient‐specific establishment of bacterial composition within the peri‐implant microbiota during the earliest weeks after implant uncovering2021

    • Author(s)
      Shimogishi Masahiro、Watanabe Takayasu、Shibasaki Masaki、Shiba Takahiko、Komatsu Keiji、Nemoto Takashi、Ishihara Kazuyuki、Nakano Yoshio、Iwata Takanori、Kasugai Shohei、Nakagawa Ichiro
    • Journal Title

      Journal of Periodontal Research

      Volume: 56 Issue: 5 Pages: 964-971

    • DOI

      10.1111/jre.12898

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An In Vitro Mixed Infection Model With Commensal and Pathogenic Staphylococci for the Exploration of Interspecific Interactions and Their Impacts on Skin Physiology2021

    • Author(s)
      Kohda Katsunori、Li Xuan、Soga Naoki、Nagura Risa、Duerna Tie、Nakajima Saeko、Nakagawa Ichiro、Ito Masakazu、Ikeuchi Akinori
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 11 Pages: 712360-712360

    • DOI

      10.3389/fcimb.2021.712360

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biological Effect of Streptococcus pyogenes-Released Extracellular Vesicles on Human Monocytic Cells, Induction of Cytotoxicity, and Inflammatory Response2021

    • Author(s)
      Murase Kazunori、Aikawa Chihiro、Nozawa Takashi、Nakatake Ayako、Sakamoto Kuniyo、Kikuchi Taisei、Nakagawa Ichiro
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 11 Pages: 711144-711144

    • DOI

      10.3389/fcimb.2021.711144

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)12021

    • Author(s)
      Daniel J Klionsky、Shu Aizawa、Amal Kamal Abdel-Aziz、Sara Abdelfatah、Mahmoud Abdellatif、Asghar Abdoli、Steffen Abel、Hagai Abeliovich、Marie H Abildgaard、Yakubu Princely Abudu、Abraham Acevedo-Arozena、Iannis E Adamopoulos、Khosrow Adeli、Timon E Adolph、Annagrazia Adornetto、Elma Aflaki、Galila Agam et al.
    • Journal Title

      Autophagy

      Volume: 17 Issue: 1 Pages: 1-382

    • DOI

      10.1080/15548627.2020.1797280

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase2021

    • Author(s)
      Nozawa Takashi、Iibushi Junpei、Toh Hirotaka、Minowa-Nozawa Atsuko、Murase Kazunori、Aikawa Chihiro、Nakagawa Ichiro
    • Journal Title

      mBio

      Volume: 12 Issue: 1

    • DOI

      10.1128/mbio.01974-20

    • NAID

      120006958085

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autophagy Receptor Tollip Facilitates Bacterial Autophagy by Recruiting Galectin-7 in Response to Group A Streptococcus Infection2020

    • Author(s)
      Lin Ching-Yu、Nozawa Takashi、Minowa-Nozawa Atsuko、Toh Hirotaka、Hikichi Miyako、Iibushi Junpei、Nakagawa Ichiro
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 10 Pages: 583137-583137

    • DOI

      10.3389/fcimb.2020.583137

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Group A Streptococcus-Containing Autophagosome-Like Vacuoles2020

    • Author(s)
      Nozawa Takashi、Nakagawa Ichiro
    • Journal Title

      Group A Streptococcus

      Volume: 2136 Pages: 223-231

    • DOI

      10.1007/978-1-0716-0467-0_16

    • ISBN
      9781071604663, 9781071604670
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intracellular Group A Streptococcus induces Golgi fragmentation to impair host defenses through Streptolysin O and NAD-glycohydrolase2020

    • Author(s)
      Nozawa Takashi、Iibushi Junpei、Toh Hirotaka、Minowa-Nozawa Atsuko、Murase Kazunori、Aikawa Chihiro、Nakagawa Ichiro
    • Journal Title

      bioRxiv

      Volume: 0 Pages: 207897-207897

    • DOI

      10.1101/2020.07.16.207894

    • NAID

      120006958085

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complete Genome Sequences of Streptococcus pyogenes Serotype M3, M28, and M89 Strains Isolated from Human Patients in Japan, 1994 to 20092020

    • Author(s)
      Murase Kazunori、Nozawa Takashi、Aikawa Chihiro、Nagao Miki、Ikebe Tadayoshi、Yoshida Akemi、Kikuchi Taisei、Nakagawa Ichiro
    • Journal Title

      Microbiology Resource Announcements

      Volume: 9 Issue: 42

    • DOI

      10.1128/mra.01047-20

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complete Genome Sequences of Two Streptococcus suis Strains Isolated from Asymptomatic Pigs2020

    • Author(s)
      Minowa-Nozawa Atsuko、Nozawa Takashi、Takamatsu Daisuke、Yoshida Akemi、Murase Kazunori、Kikuchi Taisei、Ishida-Kuroki Kasumi、Nitta Yoshihiro、Sekizaki Tsutomu、Nakagawa Ichiro
    • Journal Title

      Microbiology Resource Announcements

      Volume: 9 Issue: 47

    • DOI

      10.1128/mra.01142-20

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps.2020

    • Author(s)
      Tanaka M, Kinoshita-Daitoku R, Kiga K, Sanada T, Zhu B, Okano T, Aikawa C, Iida T, Ogura Y, Hayashi T, Okubo K, Kurosawa M, Hirahashi J, Suzuki T, Nakagawa I, Nangaku M, Mimuro H.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 3251-3251

    • DOI

      10.1038/s41598-020-60306-w

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy.2020

    • Author(s)
      Nozawa T, Sano S, Minowa-Nozawa A, Toh H, Nakajima S, Murase K, Aikawa C, Nakagawa I.
    • Journal Title

      Nat Commun.

      Volume: 11 Issue: 1 Pages: 770-770

    • DOI

      10.1038/s41467-020-14533-4

    • NAID

      120006840172

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Group A Streptococcus modulates RAB1- and PIK3C3 complex-dependent autophagy.2019

    • Author(s)
      Toh H, Nozawa T, Minowa-Nozawa A, Hikichi M, Nakajima S, Aikawa C, Nakagawa I.
    • Journal Title

      Autophagy

      Volume: 14 Issue: 2 Pages: 1-13

    • DOI

      10.1080/15548627.2019.1628539

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complete Genome Sequences of Streptococcus pneumoniae Strains HU-OH (Serotype 3, Sequence Type 183 [ST183]), NU83127 (Serotype 4, ST246), and ATCC 49619 (Serotype 19F, ST1203)2019

    • Author(s)
      Nagaoka Kentaro、Konno Satoshi、Murase Kazunori、Kikuchi Taisei、Morinaga Yoshitomo、Yanagihara Katsunori、Nakagawa Ichiro
    • Journal Title

      Microbiology Resource Announcements

      Volume: 8 Issue: 9

    • DOI

      10.1128/mra.01504-18

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] LAMTOR2/LAMTOR1 complex is required for TAX1BP1-mediated xenophagy2019

    • Author(s)
      Lin Ching-Yu、Nozawa Takashi、Minowa-Nozawa Atsuko、Toh Hirotaka、Aikawa Chihiro、Nakagawa Ichiro
    • Journal Title

      Cellular Microbiology

      Volume: 21 Issue: 4

    • DOI

      10.1111/cmi.12981

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Group A Streptococcus NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells.2019

    • Author(s)
      Toh H, Lin CY, Nakajima S, Aikawa C, Nozawa T, Nakagawa I.
    • Journal Title

      Front Cell Infect Microbiol.

      Volume: 9 Pages: 398-398

    • DOI

      10.3389/fcimb.2019.00398

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia2019

    • Author(s)
      Takahashi Ichiro, Hosomi Koji, Nagatake Takahiro, Tobou Hirokazu, Yamamoto Daiki, Hayashi Ikue, Kurashima Yosuke, Sato Shintaro, Shibata Naoko, Goto Yoshiyuki, Maruyama Fumito, Nakagawa Ichiro, Kuwae Asaomi, Abe Akio, Kunisawa Jun, Kiyono Hiroshi
    • Journal Title

      International Immunology

      Volume: 32 Issue: 2 Pages: 133-141

    • DOI

      10.1093/intimm/dxz071

    • NAID

      120006888456

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional dysbiosis within dental plaque microbiota in cleft lip and palate patients2019

    • Author(s)
      Funahashi Kenta、Shiba Takahiko、Watanabe Takayasu、Muramoto Keiko、Takeuchi Yasuo、Ogawa Takuya、Izumi Yuichi、Sekizaki Tsutomu、Nakagawa Ichiro、Moriyama Keiji
    • Journal Title

      Progress in Orthodontics

      Volume: 20 Issue: 1 Pages: 11-11

    • DOI

      10.1186/s40510-019-0265-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Complete Genome Sequences of Eight Methicillin-Resistant Staphylococcus aureus Strains Isolated from Patients in Japan2019

    • Author(s)
      Hikichi Miyako、Nagao Miki、Murase Kazunori、Aikawa Chihiro、Nozawa Takashi、Yoshida Akemi、Kikuchi Taisei、Nakagawa Ichiro
    • Journal Title

      Microbiology Resource Announcements

      Volume: 8 Issue: 47 Pages: 01212-19

    • DOI

      10.1128/mra.01212-19

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Complete Genome Sequence of Streptococcus agalactiae Serotype III, Multilocus Sequence Type 335 Strain HU-GS5823, Isolated from a Human Patient in Japan with Severe Invasive Infection2018

    • Author(s)
      Nagaoka Kentaro、Konno Satoshi、Murase Kazunori、Kikuchi Taisei、Nakagawa Ichiro
    • Journal Title

      Microbiology Resource Announcements

      Volume: 7 Issue: 20

    • DOI

      10.1128/mra.01303-18

    • NAID

      120006585789

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 生命金属の新潮流(新学術領域との共催)2021

    • Author(s)
      中川一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 化膿連鎖球菌由来金属獲得蛋白質 MtsA に対する機能阻害剤の探索2021

    • Author(s)
      中木戸 誠,竹内 美結,長門石 曉,相川 知宏,中川 一路,津本 浩平
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] A 群レンサ球菌の増殖に必要な鉄獲得機構に対する阻害剤の探索2021

    • Author(s)
      相川 知宏,長門石 曉,中木戸 誠,妹尾 暁暢,星野 将人,野澤 孝志,村瀬 一典,津本 浩平,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ESCRT 機構による A 群レンサ球菌感染制御2021

    • Author(s)
      野澤 孝志,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] GBP1 は TBK1 のリン酸化を介して A 群レンサ球菌に対する選択 的オートファジーを制御する2021

    • Author(s)
      曵地 京,野澤 孝志,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] A 群レンサ球菌が産生する細胞外小胞の病原性への関与2021

    • Author(s)
      村瀬 一典,相川 知宏,野澤 孝志,中武 彩子,菊地 泰生,中川 一 路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] オートファジー関連因子 ATG9 は A 群レンサ球菌の細胞内への侵 入を制御する2021

    • Author(s)
      飯伏 純平,藤 博貴,野澤 孝志,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] TBC1D9を介したカルシウムシグナリングはTBK1依存性ゼノファジーを制御する2020

    • Author(s)
      中川一路
    • Organizer
      第32回日本生体防御学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 化膿連鎖球菌由来金属獲得蛋白質 MtsA に対する機能阻害剤の探索2020

    • Author(s)
      中木戸 誠,竹内 美結,長門石 曉,相川 知宏,中川 一路,津本 浩平
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] A 群レンサ球菌の増殖に必要な鉄獲得機構に対する阻害剤の探索2020

    • Author(s)
      相川 知宏,長門石 曉,中木戸 誠,妹尾 暁暢,星野 将人,野澤 孝志,村瀬 一典,津本 浩平,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] ESCRT 機構による A 群レンサ球菌感染制御2020

    • Author(s)
      野澤 孝志,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] GBP1はTBK1 のリン酸化を介してA 群レンサ球菌に対する選択的オートファジーを制御する2020

    • Author(s)
      曵地 京,野澤 孝志,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] オートファジー関連因子ATG9はA 群レンサ球菌の細胞内への侵入を制御する2020

    • Author(s)
      飯伏 純平,藤 博貴,野澤 孝志,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] A群レンサ球菌の分泌毒素NAD-glycohydrolaseはATG14-PIK3C3複合体および RAB1依存的なオートファゴソーム形成を阻害する2019

    • Author(s)
      藤博貴、中島慎太郎、 相川知宏、 野澤敦子、 野澤孝志、 中川一路
    • Organizer
      第51回レンサ球菌研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 曵地京、野澤孝志、中川一路2019

    • Author(s)
      A群レンサ球菌に対するゼノファジー誘導の分子機構
    • Organizer
      第51回レンサ球菌研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] A群レンサ球菌感染に対するゼノファジーの制御2019

    • Author(s)
      中川一路
    • Organizer
      第62回日本感染症学会中日本地方会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 分子間相互作用阻害に基づく 菌種特異的な増殖阻害剤の開発2019

    • Author(s)
      中川一路
    • Organizer
      第92回日本生化学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Regulation of xenophagy in group A Streptococcus infection2019

    • Author(s)
      中川一路
    • Organizer
      第18回淡路国際面系と感染フォーラム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Xenophagy induction mechanism during Group A Streptococcus infection2019

    • Author(s)
      野澤 孝志,中川 一路
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] A 群レンサ球菌感染に対するゼノファジーの制御2019

    • Author(s)
      中川一路
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 物理化学的アプローチによる低分子阻害剤の探索および抗体阻害 剤の開発2019

    • Author(s)
      中木戸誠 ,相川知宏,長門石曉,妹尾暁暢,竹内美 結 ,星野 将人 ,下村 拓矢 ,Jose M. M. Caaveiro ,中川 一路, 津本浩平
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] A 群レンサ球菌は宿主細胞内膜輸送経路を破綻させることで上皮 バリアシステムの恒常性を低下させる2019

    • Author(s)
      飯伏 純平,藤 博貴,野澤 孝志,中川 一路
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] デンタルインプラントの口腔内露出後に生じる周囲細菌叢の経時変化2019

    • Author(s)
      下岸将博 ,渡辺孝康 ,柴崎真樹 ,中野善夫 ,春日井昇平 ,中川 一路
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] A 群レンサ球菌の毒素 NAD-glycohydrolase は宿主リン脂質ホス ホイノシタイドへの結合能を有する2019

    • Author(s)
      藤 博貴 ,野澤 孝志 ,中川 一路
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] インターフェロン誘導性の抗病原体因子 GBP1 は TBK1 と複合体 を形成してゼノファジーを制御する2019

    • Author(s)
      曵地 京,野澤 孝志,中川 一路
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 化合物 H1 の A 群レンサ球菌増殖抑制メカニズムおよび抗菌薬と の併用効果の検証2019

    • Author(s)
      相川知宏、星野将人、中木戸誠、長門石暁、村瀬一典、津本浩平、中川一路
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Remarks] 京都大学医学部微生物感染症学分野

    • URL

      http://www.bac.med.kyoto-u.ac.jp

    • Related Report
      2021 Annual Research Report
  • [Remarks] 京都大学大学院医学研究科微生物感染症学分野

    • URL

      http://www.bac.med.kyoto-u.ac.jp

    • Related Report
      2020 Research-status Report
  • [Remarks] http://www.bac.med.kyoto-u.ac.jp

    • Related Report
      2019 Research-status Report
  • [Remarks] http://www.bac.med.kyoto-u.ac.jp

    • Related Report
      2018 Research-status Report

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Published: 2018-10-12   Modified: 2023-01-30  

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