| Co-Investigator(Kenkyū-buntansha) |
川岸 将彦 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (60323606)
齊藤 健太 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (60374659)
佐藤 啓介 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (60644044)
中木戸 誠 東京大学, 大学院工学系研究科(工学部), 講師 (80784511)
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| Budget Amount *help |
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2022: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2019: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2018: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
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| Outline of Final Research Achievements |
We have succeeded in expanding the variety of artificial antibody-like molecule in the POLArIS probe, a novel probe for fluorescence polarized microspectroscopies. Regarding a probe targeting actin, both the direction of fluorescent dipole moment and the binding state to actin fibers were determined. Using this probe, we observed actin dynamics during starfish oocyte/embryo development and succeeded in discovering previously unknown dynamics of global actin structure. Currently, optimizations of both various spectroscopies and probes are underway.
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