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Advancement and Global Distribution of Cutting-Edge Radiation Therapy Technology through the International Medical Physics Network

Research Project

Project/Area Number 18KK0240
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 52:General internal medicine and related fields
Research InstitutionKyoto University

Principal Investigator

Nakamura Mitsuhiro  京都大学, 医学研究科, 教授 (30584255)

Co-Investigator(Kenkyū-buntansha) 丹羽 恵 (宇藤恵)  京都大学, 医学研究科, 助教 (20826028)
椋本 宜学  大阪公立大学, 大学院医学研究科, 病院講師 (50736618)
溝脇 尚志  京都大学, 医学研究科, 教授 (90314210)
小野 智博  京都大学, 医学研究科, 特定助教 (90782657)
角谷 倫之  東北大学, 大学病院, 助教 (20604961)
Project Period (FY) 2018-10-09 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2022: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2021: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2019: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords医学物理学 / 放射線治療 / 品質管理 / 国際標準化
Outline of Final Research Achievements

The aim of this study is to establish a foundation for international collaborative research and development in medical physics based on the international network built through previous research activities. By sharing information and human resources, the goal is to create and disseminate universally applicable cutting-edge technologies for high-precision radiation therapy. Collaborations were established with various institutions, including the Free University of Brussels, Erlangen University, Vancouver Cancer Centre, Peter MacCallum Cancer Centre, Clatterbridge Cancer Centre, and MD Anderson Cancer Centre, as well as more than 15 domestic facilities. The study involved the creation of a reference beam data model for the Vero radiation therapy device, the development and verification of a phantom for deformable image registration, and the development of an IMRT dose verification and auditing system.

Academic Significance and Societal Importance of the Research Achievements

国際ネットワークの構築や情報・人的資源の共有によって,高精度放射線治療における普遍的な先端技術の創出と普及が可能となる.これにより,放射線治療の精度や効果を向上させるための新規技術開発が推進される.さらに,国内外の研究機関や施設との協力により,異なる視点や専門知識を結集することができ,より総合的な研究成果が得られることも期待される.本研究成果は放射線治療の分野において重要な進歩をもたらすことが期待される.高精度放射線治療技術の普及により,がん患者の治療効果や生存率が向上する可能性がある.また,国内外の施設との連携や知識共有により,地域や国を超えた医療の質の向上に寄与すること期待される.

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Products Report
  • Research Products

    (18 results)

All 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (7 results) Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (5 results) (of which Int'l Joint Research: 2 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] Vancouver Cancer Center(カナダ)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Peter MacCallum Cancer Center(オーストラリア)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Vancouver Cancer Center(カナダ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Clatterbridge Cancer Center(英国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Peter MacCallum Cancer Center(オーストラリア)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] ブリュッセル自由大学(ベルギー)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] エアランゲン大学(ドイツ)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Dosimetric impact of deformable image registration using radiophotoluminescent glass dosimeters with a physical geometric phantom2023

    • Author(s)
      Siwaporn Sakulsingharoj, Noriyuki Kadoya, Shohei Tanaka, Erika Segawa, Kiyokazu Sato, Mitsuhiro Nakamura, Keiichi Jingu.
    • Journal Title

      J. Appl. Clin. Med. Phys.

      Volume: e13890 Issue: 4 Pages: 1-13

    • DOI

      10.1002/acm2.13890

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A virtual audit system for intensity-modulated radiation therapy credentialing in Japan Clinical Oncology Group clinical trials: A pilot study2023

    • Author(s)
      Mitsuhiro Nakamura, Dejun Zhou, Toshiyuki Minemura, Satoshi Kito, Hiroyuki Okamoto, Naoki Tohyama, Masahiko Kurooka, Yu Kumazaki, Masayori Ishikawa, Catharine H Clark, Elizabeth Miles, Joerg Lehmann, Nicolaus Andratschke, Stephen Kry, Satoshi Ishikura, Takashi Mizowaki, Teiji Nishio
    • Journal Title

      J. Appl. Clin. Med. Phys.

      Volume: e14040 Issue: 6 Pages: 1-9

    • DOI

      10.1002/acm2.14040

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a physical geometric phantom for deformable image registration credentialing of radiotherapy centers for a clinical trial2021

    • Author(s)
      Noriyuki Kadoya, Siwaporn Sakulsingharoj, Tomas Kron, Adam Yao, Nicholas Hardcastle, Alanah Bergman, Hiroyuki Okamoto, Nobutaka Mukumoto, Yujiro Nakajima, Keiichi Jingu, Mitsuhiro Nakamura
    • Journal Title

      J Appl Clin Med Phys

      Volume: 22 Issue: 7 Pages: 255-265

    • DOI

      10.1002/acm2.13319

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Monte Carlo simulation of 6 MV dynamic wave VMAT deliveries by Vero4DRT linear accelerator using EGSnrc moving sources2020

    • Author(s)
      Rostamzadeh Maryam, Ishihara Yoshitomo, Nakamura Mitsuhiro, Popescu Antoniu, Mestrovic Ante, Gete Ermias, Fedrigo Roberto, Bergman Alanah
    • Journal Title

      J Appl Clin Med Phys

      Volume: 21 Issue: 12 Pages: 206-218

    • DOI

      10.1002/acm2.13090

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 商用非剛体レジストレーション検証用物理ファントムを用いた位置照合精度評価2022

    • Author(s)
      矢後希皐,角谷倫之,Siwaporn Sakulsingharoj,星野大地,佐藤清和,勝田義之,田中祥平, 新井一弘, 中村光宏,神宮啓一
    • Organizer
      第35回日本放射線腫瘍学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Effect of couch rotation on positional errors at off-isocenter positions2021

    • Author(s)
      Takahisa Kido, Mitsuhiro Nakamura, Tomohiro Ono, Hiraku Iramina, Ryo Kakino, Takashi Mizowaki
    • Organizer
      The 9th Korea-Japan Joint Meeting on Medical Physic
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of CBCT to CT deformable image registration accuracy using a geometric physical phantom2021

    • Author(s)
      Erika Segawa, Noriyuki Kadoya, Tomoya Ishida, Siwaporn Sakulsingharoj, Shohei Tanaka, Suguru Dobashi, Ken Takeda, Keiichi Jingu , Mitsuhiro Nakamura
    • Organizer
      The 9th Korea-Japan Joint Meeting on Medical Physic
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] DIRソフトウェアのEnd to end試験用物理ファントムの開発2019

    • Author(s)
      角谷 倫之,細谷 祐里,根本 光,田中 祥平,松田 匠平,武田 賢,土橋 卓,神宮 啓一,中村 光宏
    • Organizer
      日本放射線腫瘍学会 第32回学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] DIR end-to-end 物理ファントムの 臨床的有効性の検討2019

    • Author(s)
      細谷 祐里,角谷 倫之,根本 光,田中 祥平,松田 匠平,武田 賢,土橋 卓,神宮 啓一,中村 光宏
    • Organizer
      日本放射線腫瘍学会 第32回学術大会
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 非剛体画像レジストレーション調整支援装置、非剛体画像レジストレーション調整支援方法及びプログラム2023

    • Inventor(s)
      中村光宏, 角谷倫之, 根本光, 阿部幸太, 田中祥平, 細谷祐里, 神宮啓一
    • Industrial Property Rights Holder
      国立大学法人京都大学, 国立大学法人東北大学
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2023
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] 非剛体画像レジストレーション調整支援装置、非剛体画像レジストレーション調整支援方法及びプログラム2019

    • Inventor(s)
      角谷 倫之,中村 光宏
    • Industrial Property Rights Holder
      角谷 倫之,中村 光宏
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-209949
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report

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Published: 2018-10-12   Modified: 2025-03-27  

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