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Functional analyses and regulation of the metabolism of tissue microenvironmental factors by metalloproteinases

Research Project

Project/Area Number 19109004
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionKeio University

Principal Investigator

OKADA Yasunori  慶應義塾大学, 医学部, 教授 (00115221)

Co-Investigator(Kenkyū-buntansha) MOCHIZUKI Satsuki  慶應義塾大学, 医学部, 講師 (80365428)
IKEDA Eiji  山口大学, 医学部, 教授 (30232177)
SHIMODA Masayuki  慶應義塾大学, 医学部, 助教 (70383734)
FUJII Yutaka  福井大学, 医学部, 教授 (80211522)
KIMURA Tokuhiro  慶應義塾大学, 医学部, 助教 (40445200)
SASAKI Aya  慶應義塾大学, 医学部, 助教 (60343381)
Co-Investigator(Renkei-kenkyūsha) KIRAN Chada  ニュージャージ医科歯科大学, 医学部, 教授
JEANINE D' armiento  コロンビア大学, 医学部, 准教授
Project Period (FY) 2007 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥116,610,000 (Direct Cost: ¥89,700,000、Indirect Cost: ¥26,910,000)
Fiscal Year 2011: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2010: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2009: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2008: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2007: ¥40,950,000 (Direct Cost: ¥31,500,000、Indirect Cost: ¥9,450,000)
KeywordsMMP / ADAM / ノックアウトマウス / 浸潤 / 転移 / 創傷治癒 / 変形性関節症 / ヒアルロン酸 / エンドスタチン / 動脈瘤 / セマフォリン / ELISA / 癌転移 / 血管新生 / ADAMTS4 / アグリカナーゼ / IL-1 / CD44 / カルシウムペントサン硫酸 / 筋線維芽細胞 / ヘパラナーゼ / 腎癌
Research Abstract

We searched for interacting molecules for members of the MMP (matrix metalloproteinase) and the ADAM (a disintegrin and metalloproteinase) gene families, and investigated roles of these metalloproteinases in metabolism of tissue microenvironmental factors in cancers and non-neoplastic diseases with an aim of developing novel diagnostic and/or therapeutic tools. Our studies provided progresses in purification of several proMMPs, roles of MMPs in skin wound healing, implications of ADAM28 in cancer cell proliferation and metastasis, development of a measuring method for ADAM28, and roles of ADAMTS4 and ADAM12 in destruction and repair of osteoarthritic cartilage.

Report

(7 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (96 results)

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article (60 results) (of which Peer Reviewed: 57 results) Presentation (20 results) Book (11 results) Remarks (5 results)

  • [Journal Article] Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor2012

    • Author(s)
      Mochizuki S., Soejima K., Shimoda M., Abe H., Sasaki A., Okano H. J., Okano H. and Okada Y
    • Journal Title

      J. Natl. Cancer Inst

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production2011

    • Author(s)
      Fukuda H., Mochizuki S., Abe H., Okano H. J., Hara-Miyauchi C., Okano H., Yamaguchi N., Nakayama M., D' Armiento J. and Okada Y
    • Journal Title

      Br J Cancer

      Volume: 105 Pages: 1615-1624

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Semaphorin 3A is expressed in human osteoarthritic cartilage and antagonizes vascular endothelial growth factor_(165)-promoted chondrocyte migration : an implication for chondrocyte cloning2011

    • Author(s)
      Okubo M., Kimura T., Fujita Y., Mochizuki S., Niki Y., Enomoto H., Suda Y., Toyama Y. and Okada Y
    • Journal Title

      Arthr itis Rheum

      Volume: 63 Pages: 3000-3009

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Snail and Slug in renal cell carcinoma : E-cadherin repressor Snail is associated with cancer invasion and prognosis2011

    • Author(s)
      Mikami S., Katsube K., Oya M., Ishida M., Kosaka T., Mizuno R., Mukai M. and Okada Y
    • Journal Title

      Lab. Invest

      Volume: 91 Pages: 1443-1458

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necross factor-αconverting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis2011

    • Author(s)
      Kaneko H., Anzai T., Horiuchi K., Morimoto K., Anzai A., Nagai T., Sugano Y. Maekawa Y., Itoh H., Yoshikiwa T., Okada Y., Ogawa S. and Fukuda K
    • Journal Title

      Cirulation J

      Volume: 75 Pages: 2482-2490

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor-αconverting enzyme is a key mediator of abdominal aortic aneurysm development2011

    • Author(s)
      Kaneko H., Anzai T., Horiuchi K., Kohno T., Nagai T., Anzai A., Takahashi T., Sasaki A., Shimoda M., Maekawa Y., Shimizu H., Yoshikawa T., Okada Y., Yozu R. and Fukuda K
    • Journal Title

      Atherosclerosis

      Volume: 218 Pages: 470-478

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts2011

    • Author(s)
      Kawakami T., Sameshima T., Hojo H., Koga K., Nakahara Y., Toole B.P., Okada Y., Iwasaki A., Nabeshima K.
    • Journal Title

      BMC Cancer

      Volume: 11 Issue: 1 Pages: 300-300

    • DOI

      10.1186/1471-2407-11-300

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Semaphorin 3A is expressed in human osteoarthritic cartilage and antagonizes vascular endothelial growth factor_<165>-promoted chondrocyte migration : an implication for chondrocyte cloning2011

    • Author(s)
      Okubo M., Kimura T., Fujita Y., Mochizuki S., Niki Y., Enomoto H., Suda Y., Toyama Y., Okada Y.
    • Journal Title

      Arthritis Rheum

      Volume: 63 Pages: 3000-3009

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm2011

    • Author(s)
      Kaneko H., Anzai T., Takahashi T., Kohno T., Shimoda M., Sasaki A., Shimizu H., Nagai T., Maekawa Y., Yoshimura K., Aoki H., Yoshikawa T., Okada Y., Yozu R., Ogawa S., Fukuda K.
    • Journal Title

      Cardiovasc Res

      Volume: 91 Pages: 358-367

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resveratrol prevents development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization2011

    • Author(s)
      Kaneko H., Anzai T., Morisawa M., Kohno T., Nagai T., Anzai A., Takahashi T., Shimoda M., Sasaki A., Maekawa Y., Yoshimura K., Aoki H., Tsubota K., Yoshikawa T., Okada Y., Ogawa S., Fukuda K.
    • Journal Title

      Atherosclerosis

      Volume: 217 Pages: 350-357

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor-α converting enzyme is a key mediator of abdominal aortic aneurysm development2011

    • Author(s)
      Kaneko H., Anzai T., Horiuchi K., Kohno T., Nagai T., Anzai A., Takahashi T., Sasaki A., Shimoda M., Maekawa Y., Shimizu H., Yoshikawa T., Okada Y., Yozu R., Fukuda K.
    • Journal Title

      Atherosclerosis

      Volume: 218 Pages: 470-478

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production2011

    • Author(s)
      Fukuda H., Mochizuki S., Abe H., Okano H.J., Hara-Miyauchi C., Okano H., Yamaguchi N., Nakayama M., D'Armiento J., Okada Y.
    • Journal Title

      Brit J Cancer

      Volume: 105 Pages: 1615-1624

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Snail arid Slug in renal cell carcinoma : E-cadherin repressor Snail is associated with cancer invasion and prognosis2011

    • Author(s)
      Mikami S., Katsube K., Oya M., Ishida M., Kosaka T., Mizuno R., Mukai M., Okada Y.
    • Journal Title

      Lab Invest

      Volume: 91 Pages: 1443-1458

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells2011

    • Author(s)
      Shirakabe K., Hattori S., Seiki M., Koyasu S., Okada Y.
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 43154-43163

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necross factor-α converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis2011

    • Author(s)
      Kaneko H., Anzai T., Horiuchi K., Morimoto K., Anzai A., Nagai T., Sugano Y., Maekawa Y., Itoh H., Yoshikiwa T., Okada Y., Ogawa S., Fukuda K.
    • Journal Title

      Cirulation J

      Volume: 75 Pages: 2482-2490

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual functions of cell-autonomous and non cell-autonomous ADAM10 activity in granulopoiesis2011

    • Author(s)
      Yoda M., Kimura T., Link D.C., Chiba K., Okada Y., Matsumoto M., Toyama Y., Horiuchi K.
    • Journal Title

      Blood

      Volume: 118 Pages: 6939-6942

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory role of dendritic cells in post-infarction healing and left ventricular remodeling2011

    • Author(s)
      Anzai A., Anzai T., Nagai S., Maekawa Y., Naito K., Kaneko H., Sugano Y., Takahashi T., Abe H., Mochizuki S., Sano M., Yoshikawa T., Okada Y., Koyasu S., Ogawa S., Fukuda K.
    • Journal Title

      Circulation

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RECK is up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage2010

    • Author(s)
      Kimura T., Okada A., Yatabe T., Okubo M., Toyama Y., Noda M. and Okada Y
    • Journal Title

      Am. J. Pathol

      Volume: 176 Pages: 2858-2867

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ADAM28 is a serological and histochemical marker for non-small-cell lung cancers2010

    • Author(s)
      Kuroda H., Mochizuki S., Shimoda M., Chijiiwa M., Kamiya K., Izumi Y., Watanabe M., Horinouchi H., Kawamura M., Kobayashi K. and Okada Y
    • Journal Title

      Int. J. Cancer

      Volume: 127 Pages: 1844-1856

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Connective tissue growth factor is a substrate of ADAM282010

    • Author(s)
      Mochizuki, S., Tanaka R., Shimoda M., Onuma J., Fujii Y., Jinno H. and Okada Y
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 402 Pages: 651-657

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents2010

    • Author(s)
      Hakuno, D., Kimura, N., Yoshioka, M., Mukai, M., Kimura, T., Okada, Y., Yozu, R., Shukunami, C., Hiraki, Y., Kudo, A., Ogawa, S. and Fukuda, K
    • Journal Title

      J. Clin. Invest

      Volume: 120 Pages: 2292-2306

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of snail in upper urinary tract urothelial carcinoma : prognostic significance and implications for tumor invasion2010

    • Author(s)
      Kosaka T, Kikuchi E, Mikami S, Miyajima A, Shirotake S, Ishida M, Okada Y, Oya M
    • Journal Title

      Clin Cancer Res

      Volume: 16 Pages: 5814-23

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents.2010

    • Author(s)
      Hakuno, D., Kimura, N., Yoshioka, M., Mukai, M., Kimura, T., Okada, Y., Yozu, R., Shukunami, C., Hiraki, Y., Kudo, A., Ogawa, S., Fukuda, K.
    • Journal Title

      J Clin Invest

      Volume: 120 Pages: 2292-2306

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production and activation of matrix metalloproteinase-7 (matrilysin-1) in the lungs of patients with idiopathic pulmonary fibrosis.2010

    • Author(s)
      Fujishima S., Shiomi T., Yamashita S., Yogo Y., Nakano Y., Inoue T., Nakamura M., Tasaka S., Hasegawa N., Aikawa N., Ishizaka A., Okada Y.
    • Journal Title

      Arch.Pathol.Lab.Med.

      Volume: 134 Pages: 1136-1142

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Absence of gelatinase (MMP-9) or collagenase (MMP-13) attenuates adriamycin-induced albuminuria and glomerulosclerosis.2010

    • Author(s)
      Sakamaki Y., Sasamura H., Hayashi K., Ishiguro K., Takaishi H., Okada Y., D'Armiento J., Saruta T., Itoh H.
    • Journal Title

      Nephron Exp Nephrology

      Volume: 115

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the Aryl hydrocarbon receptor pathway enhances cancer cell invasion by up-regulating the MMP expression and is associated with poor prognosis in upper urinary tract urothelial cancer.2010

    • Author(s)
      Ishida M., Mikami S., Kikuchi E., Kosaka T., Miyajima A., Nakagawa K., Mukai M., Okada Y., Oya M.
    • Journal Title

      Carcinogenesis

      Volume: 31 Pages: 287-295

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.2010

    • Author(s)
      Kuroda H., Mochizuki S., Shimoda M., Chijiiwa M., Kamiya K., Izumi Y., Watanabe M., Horinouchi H., Kawamura M., Kobayashi K., Okada Y.
    • Journal Title

      Int J Cancer

      Volume: 127 Pages: 1844-1856

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RECK is up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage.2010

    • Author(s)
      Kimura T., Okada A., Yatabe T., Okubo M., Toyama Y., Noda M., Okada Y.
    • Journal Title

      Am J Pathol

      Volume: 176 Pages: 2858-2867

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MMPs, ADAMs and ADAMTSs in non-neoplastic diseases.2010

    • Author(s)
      Shiomi T., Lemaitre V., D'Armiento J., Okada Y.
    • Journal Title

      Pathol.Int.

      Volume: 60 Pages: 477-496

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Connective tissue growth factor is a substrate of ADAM28.2010

    • Author(s)
      Mochizuki, S., Tanaka R., Shimoda M., Onuma J., Fujii Y., Jinno H., Okada Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 402 Pages: 651-657

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma.2010

    • Author(s)
      Stokes A., Joutsa J.T., Ala-aho R., Pitchers M., Pennington C.J., Martin C., Premachandra D.J., Okada Y., Peltonen J., Grenman R., James H.A., Edwards D.R., Kahari V-M
    • Journal Title

      Clin Cancer Res

      Volume: 16 Pages: 2022-2035

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of snail in upper urinary tract urothelial carcinoma : prognostic significance and implications for tumor invasion.2010

    • Author(s)
      Kosaka T, Kikuchi E, Mikami S, Miyajima A, Shirotake S, Ishida M, Okada Y, Oya M.
    • Journal Title

      Clin Cancer Res

      Volume: 16 Pages: 5814-5823

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.2010

    • Author(s)
      Kuroda H., Mochizuki S., Shimoda M., Chijiiwa M., Kamiya K., Izumi Y., Watanabe M., Horinouchi H., Kawamura M., Kobayashi K., Okada Y.
    • Journal Title

      Int J Cancer (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes2009

    • Author(s)
      Yatabe T., Mochizuki S., Takizawa M., Chijiiwa M., Okada A., Kimura T., Fujita Y., Matsumoto H., Toyama Y. and Okada Y
    • Journal Title

      Ann. Rheum. Dis

      Volume: 68 Pages: 1051-1058

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ADAM28 as a target for human cancers2009

    • Author(s)
      Mochizuki S. and Okada Y
    • Journal Title

      Cur r. Pharm. Des

      Volume: 15 Pages: 2349-2358

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] MMP-13 plays a role in migration, angiogenesis and contraction in mouse skin wound healing2009

    • Author(s)
      Hattori N., Mochizuki S., Kishi K., Nakajima T., Takaishi H., D' Armiento J. and Okada Y
    • Journal Title

      Am. J. Pathol

      Volume: 175 Pages: 533-546

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased RANKL expression is related to tumor migration and metastasis of renal cell carcinomas2009

    • Author(s)
      Mikami S., Katsube K., Oya M., Ishida M., Kosaka T., Mizuno R., Mochizuki S., Ikeda T., Mukai M. and Okada Y
    • Journal Title

      J. Pathol

      Volume: 218 Pages: 530-539

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF2009

    • Author(s)
      Horiuchi K, Kimura T, Miyamoto T, Miyamoto K, Akiyama H, Takaishi H, Morioka H, Nakamura T, Okada Y, Blobel CP, and Toyama Y
    • Journal Title

      J. Immunol

      Volume: 182 Pages: 2093-2101

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] MMP-13 plays a role in migration, angiogenesis and contraction in mouse skin wound healing.2009

    • Author(s)
      Hattori N., Mochizuki S., Kishi K., Nakajima T., Takaishi H., D'Armiento J., Okada Y.
    • Journal Title

      Am. J.Pathol 175

      Pages: 533-546

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] ADAM28 as a target for human cancers.2009

    • Author(s)
      Mochizuki S., Okada Y.
    • Journal Title

      Curr.Pharm.Des. 15

      Pages: 2349-2358

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MMP-13 plays a role in migration, angiogenesis and contraction in mouse skin wound healing.2009

    • Author(s)
      Hattori N., Mochizuki S., Kishi K., Nakajima T., Takaishi H., D'Armiento J., Okada Y.
    • Journal Title

      Am.J.Pathol. 175

      Pages: 533-546

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts.2009

    • Author(s)
      Hikata T, Takaishi H, Takito J, Hakozaki A, Furukawa M, Uchikawa S, Kimura T, Okada Y, Matsumoto M, Yoshimura A, Nishimura A, Reddy S V, Asahara H, Toyama Y.
    • Journal Title

      Blood 113

      Pages: 2202-2212

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF.2009

    • Author(s)
      Horiuchi K, Kimura T, Miyamoto T, Miyamoto K, Akiyama H, Takaishi H, Morioka H, Nakamura T, Okada Y. Blobel CP, Toyama Y
    • Journal Title

      J Immunol 182

      Pages: 2093-2101

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1)in humanosteoarthritic chondrocytes.2009

    • Author(s)
      Yatabe T., Mochizuki S., Takizawa M. Chijiiwa M., Okada A., Kimura T., Fujita Y. Matsumoto H., Toyama Y, Okada Y.
    • Journal Title

      Ann Rheum Dis (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ADAM12 (Meltrin α) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor-binding protein-5 in osteoarthritic cartilage2008

    • Author(s)
      Okada A., Mochizuki S., Yatabe T., Kimura T., Shiomi T., Fujita Y., Matsumoto H., Sehara-Fujisawa A., Iwamoto Y. and Okada Y
    • Journal Title

      Arthritis Rheum

      Volume: 58 Pages: 778-789

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Purification of matrix metalloproteinases by column chromatography2008

    • Author(s)
      Imai, K. and Okada Y
    • Journal Title

      Nat. Protoc

      Volume: 3 Pages: 1111-1124

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis2008

    • Author(s)
      Kimura N., Shukunami C., Hakuno D., Yoshikoka M., Miura S., Docheva D., Kimura T., Okada Y., Matsumura G., Shin' oka T., Yozu R., Kobayashi J., Ishibashi-Ueda H., Hiraki Y. and Fukuda K
    • Journal Title

      Circulation

      Volume: 118 Pages: 1737-1747

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes2008

    • Author(s)
      Takizawa M., Yatabe T., Okada A., Chijiiwa M., Mochizuki S., Ghosh P. and Okada Y
    • Journal Title

      FEBS Lett

      Volume: 582 Pages: 2945-2949

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Purification of matrix metalloproteinases by column chromatography.2008

    • Author(s)
      Imai, K., Okada Y.
    • Journal Title

      Nat Protoc 3

      Pages: 1111-1124

    • Related Report
      2009 Self-evaluation Report 2008 Annual Research Report
  • [Journal Article] ADAM12 (Meltrin a) is involved in chondrocyte proliferation viacleavage of insulin-like growth factor-binding protein-5 in osteoarthriticcartilage.2008

    • Author(s)
      Okada A., Mochizuki S., Yatabe T., Kimura T., Shiomi T., Fujita Y., Matsumoto H., Sehara-Fujisawa A., Iwamoto Y., Okada Y.
    • Journal Title

      Arthritis Rheum 58

      Pages: 778-789

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes.2008

    • Author(s)
      Takizawa M., Yatabe T., Okada A., Chijiiwa M., Mochizuki S., Ghosh P., Okada Y.
    • Journal Title

      FEBS Lett 582

      Pages: 2945-2949

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis.2008

    • Author(s)
      Kimura N., Shukunami C, Hakuno D., Yoshikoka M., Miura S., Docheva D., Kimura T., Okada Y., Matsumura G., Shin'oka T., Yozu R., Kobayashi J., Ishibashi-Ueda H., Hiraki Y. And Fukuda K.
    • Journal Title

      Circulation 118

      Pages: 1737-1747

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of heparanase in renal cell carcinomas: Implications for tumor invasion and progression.2008

    • Author(s)
      Mikami S., Oya M., Shimoda M., Mizuno R., Ishida M., Kosaka T., Mukai M., Nakajima M. Okada Y.
    • Journal Title

      Clin. Cancer Res. 14

      Pages: 6055-6061

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain-specific expression of vascular endothelial growth factor 146 correlates with the blood-brain barrier induction in quail embryos2008

    • Author(s)
      Ikeda E., Kodama T. Okada Y.
    • Journal Title

      Dev. Neurosci. 30

      Pages: 31-339

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local tenomodulin absence, angiogenesis, and matrix metalloproteninase activation are associated with the rupture of the chordae tendineae cordis.2008

    • Author(s)
      Kimura N., Shukunami C, Hakuno D., Yoshikoka M., Miura S., Docheva D., Kimura T., Okada Y., Matsumura G, Shin'oka T., Yozu R., Kobayashi J., Ishibashi-Ueda H., Hiraki Y. Fukuda K.
    • Journal Title

      Circulation 118

      Pages: 1737-1747

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ADAMs in cancer cell proliferation and progression2007

    • Author(s)
      Mochizuki S. and Okada Y
    • Journal Title

      Cancer Sci

      Volume: 98 Pages: 621-628

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum levels of matrix metalloproteinase-3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis2007

    • Author(s)
      Kobayashi A., Okazaki S., Enomoto H., Shiomi T., Obata K. and Okada Y
    • Journal Title

      Arch. Pathol. Lab. Med

      Volume: 131 Pages: 563-570

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells2007

    • Author(s)
      Shimoda M., Hashimoto G., Mochizuki S., Ikeda E., Nagai N., Ishida S. and Okada Y
    • Journal Title

      J. Biol. Chem

      Volume: 282 Pages: 25864-25874

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] TNFα-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock2007

    • Author(s)
      Horiuchi K., Kimura T., Miyamoto T., Takaishi H., Okada Y., Toyama Y. and Blobel C. P
    • Journal Title

      J. Immunol

      Volume: 179 Pages: 2686-2689

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells.2007

    • Author(s)
      Shimoda M., Hashimoto G., Mochizuki S., Ikeda E., Nagai N., Ishida S., Okada Y.
    • Journal Title

      J.Biol. Chem. 282

      Pages: 25864-25874

    • Related Report
      2009 Self-evaluation Report
  • [Presentation] メタロプロテアーゼ(MMP/ADAM)を標的としたOA治療:現状と将来2012

    • Author(s)
      岡田保典
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-03-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 病的組織破壊とリモデリングにおけるメタロプロテアーゼ(MMP/ADAM)の作用解析2012

    • Author(s)
      岡田保典
    • Organizer
      第25回肝類洞壁細胞研究会
    • Place of Presentation
      東京・東京ガーデンパレス(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] メタロプロテアーゼ(MMP/ADAM)を標的としたOA治療:現状と将来2012

    • Author(s)
      岡田保典
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      愛知・ウイルあいち(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ADAM28 promotes cancer cell proliferation and progression through metabolism of tissue microenvironmental factors2011

    • Author(s)
      Yasunori Okada
    • Organizer
      Korean Society of Matrix Biology
    • Place of Presentation
      韓国・テグ(招待講演)
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 関節リウマチにおける関節軟骨破壊とメタロプロテアーゼ2011

    • Author(s)
      岡田保典
    • Organizer
      第55回日本リウマチ学会
    • Place of Presentation
      神戸
    • Year and Date
      2011-07-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 統括病理学の時代における病理学研究2011

    • Author(s)
      岡田保典
    • Organizer
      第100回日本病理学会春期総会
    • Place of Presentation
      神奈川・パシフィコ横浜(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] MMP/ADAMと癌の増殖・浸潤・転移2011

    • Author(s)
      岡田保典
    • Organizer
      第100回日本病理学会春期総会
    • Place of Presentation
      神奈川・パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 関節リウマチにおける関節軟骨破壊とメタロプロテアーゼ2011

    • Author(s)
      岡田保典
    • Organizer
      第55回日本リウマチ学会
    • Place of Presentation
      兵庫・神戸ポートピアホテル(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production2011

    • Author(s)
      Yasunori Okada
    • Organizer
      Gordon Research Conference on Matrix Metalloproteinases
    • Place of Presentation
      米国,Smithfield, Rhode Island
    • Related Report
      2011 Annual Research Report
  • [Presentation] CTGF/VEGF165複合体形成とMMP/ADAM分子によるCTGF分解2011

    • Author(s)
      岡田保典
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      岡山・アークホテル岡山(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 関節疾患における関節軟骨の破壊と再生機構2011

    • Author(s)
      岡田保典
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      群馬・ベイシア文化ホール(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] RA滑膜組織におけるアグリカナーゼ型ADAMTS分子の発現と治療戦略2011

    • Author(s)
      岡田保典
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋・ベイシア文化ホール(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 関節軟骨のリモデリング2011

    • Author(s)
      木村徳宏、岡田保典
    • Organizer
      第57回日本病理学会秋期総会
    • Place of Presentation
      東京・日本教育会館(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Substrates and roles of ADAM28 in human cancers. Gordon Research Conference on Proteolytic Enzymes and Their Inhibitors2010

    • Author(s)
      Yasunori Okada
    • Organizer
      Invited speaker
    • Place of Presentation
      IlCiocco, Italy
    • Year and Date
      2010-05-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Substrates and roles of ADAM28 in human cancers.2010

    • Author(s)
      Yasunori Okada
    • Organizer
      Gordon Research Conference on Proteolytic Enzymes and Their Inhibitors.
    • Place of Presentation
      Il Ciocco, Italy
    • Year and Date
      2010-05-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 組織内微小環境因子代謝酵素(MMPs/ADAMs)と関節軟骨の破壊・再生2010

    • Author(s)
      岡田保典
    • Organizer
      第54回日本リウマチ学会
    • Place of Presentation
      神戸(教育講演)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] ADAMs in tumor growth and progression2009

    • Author(s)
      Yasunori Okada
    • Organizer
      In Gordon Research Conference on MMPs
    • Place of Presentation
      Les Diablerets, Switzerland
    • Year and Date
      2009-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] ADAMs in tumor growth and progression.2009

    • Author(s)
      Yasunori Okada
    • Organizer
      Gordon Research Conference on MMPs.
    • Place of Presentation
      Les Diablerets, Switzerland.
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] ADAMs in tumor growth and progression.2009

    • Author(s)
      Okada Y.
    • Organizer
      In Gordon Research Conference on MMPs
    • Place of Presentation
      Invited speaker
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] MMP/ADAMによる組織内微小環境因子代謝2008

    • Author(s)
      岡田保典
    • Organizer
      第97回日本病理学会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-15
    • Related Report
      2011 Final Research Report
  • [Book] Proteinases and matrix degradation. In Kelley's Textbook of Rheumatology2012

    • Author(s)
      Okada Y, Firestein G. S., Budd R. C., Gabriel S. E., McInnes I. B. and O' Dell J. R
    • Publisher
      Philadelphia(in press)
    • Related Report
      2011 Final Research Report
  • [Book] ADAM28. In : Handbook of Proteolytic Enzymes2012

    • Author(s)
      Mochizuki S. and Okada Y Rawlings N. D. and Salvesen G
    • Publisher
      Elsevier Ltd(in press)
    • Related Report
      2011 Final Research Report
  • [Book] Handbook of Proteolytic Enzymes2012

    • Author(s)
      Mochizuki S., Okada Y.
    • Publisher
      ADAM28(In press)
    • Related Report
      2011 Annual Research Report
  • [Book] Kelley's Textbook of Rheumatology, 9th edition2012

    • Author(s)
      Okada Y.
    • Publisher
      Proteinases and matrix degradation(In press)
    • Related Report
      2011 Annual Research Report
  • [Book] ADAM28.In : Handbook of Proteolytic Enzymes.2011

    • Author(s)
      Mochizuki S., Okada.
    • Publisher
      Elsevier Ltd, Oxford, UK.(in press)
    • Related Report
      2010 Annual Research Report
  • [Book] Proteinases and matrix degradation. In Kelley's Textbook of Rheumatology.2011

    • Author(s)
      Okada Y.
    • Publisher
      Elsevier Saunders.Philadelphia, USA.(in press)
    • Related Report
      2010 Annual Research Report
  • [Book] Immunohistochemistry of MMPs and TIMPs. In Matrix Metalloproteinase Protocols2010

    • Author(s)
      Okada Y
    • Publisher
      Humana Press Inc
    • Related Report
      2011 Final Research Report
  • [Book] Kelley's Textbook of Rheumatology2009

    • Author(s)
      Okada Y.
    • Publisher
      Elsevier Saunders
    • Related Report
      2009 Self-evaluation Report
  • [Book] Kelley's Textbook of Rheumatology.(Proteinases and matrix degradation.)2009

    • Author(s)
      Okada Y.
    • Total Pages
      19
    • Publisher
      Elsevier Saunders.
    • Related Report
      2009 Annual Research Report
  • [Book] In Kelley's Textbook of Rheumatology. Ed. by Firestein G. S., Budd R. C., Harris E. D., Jr., Mclnnes I. B., Ruddy s. and Sergent J. S. 8th edition. Elsevier Saunders. Philadelphia.2009

    • Author(s)
      Okada Y.
    • Publisher
      Proteinases and matrix degradation.
    • Related Report
      2008 Annual Research Report
  • [Book] In Matrix Metalloproteinases. Ed. by Ian M. Clark. Humana Press Inc., Totowa, NJ, USA.2009

    • Author(s)
      Okada Y.
    • Publisher
      Immuno histochemistry of MMPs and TIMPs(in press)
    • Related Report
      2008 Annual Research Report
  • [Remarks] 研究代表者:「組織内活性化制御機構解明に基づく血清MMP-3測定法の開発」で、平成22年度文部科学大臣表彰科学技術賞受賞

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://keio-okada-lab.jp/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://keio-okada-lab.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://keio-okada-lab.jp/

    • Related Report
      2009 Self-evaluation Report
  • [Remarks]

    • URL

      http://keio-okada-lab.jp/

    • Related Report
      2009 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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