Clinical application of porous bioactive titanium

• Project/Area Number: 19200039
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kyoto University
• Principal Investigator: NAKAMURA Takashi Kyoto University, 医学研究科, 教授 (10201675)
• Co-Investigator(Kenkyū-buntansha): NEO Masashi 京都大学, 医学研究科, 准教授 (80311736) ; NAKAGAWA Yasuaki 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (90293860) ; FUJIBAYASHI Syunsuke 京都大学, 医学研究科, 助教 (30362502) ; FUKUSHIMA Masanori 京都大学, 医学研究科, 教授 (80107820)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥46,540,000 (Direct Cost: ¥35,800,000、Indirect Cost: ¥10,740,000); Fiscal Year 2009: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2008: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000); Fiscal Year 2007: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
• Keywords: 人工骨 / 多孔体チタン / 生体活性 / レーザープリンティング / 臨床

Research Abstract

We developed bioactive porous titanium as an artificial bone for bone and joint reconstruction. Using this titanium lumbar fusion device was prepared for the treatment of chronic low back disease. Kyoto University institutional review board approved its clinical trial on September 2008. This trial revealed successful bony union was achieved in all five cases by 6 month after surgery without any adverse effects. We established the new system of clinical trial as well as we developed novel treatment.

Research Products

• [Journal Article] Reinforcement of tendon attachment to bioactive titanium by BMP-2-induced ectopic bone formation (2009)
  • Author(s): So K, Takemoto M, Fujibayashi S, Neo M, Kokubo T, Nakamura T.
  • Journal Title: J Biomed Mater Res A
  • Peer Reviewed
• [Journal Article] 中村孝志生体活性チタンの開発-臨床応用に向けての課題- (2009)
  • Author(s): 藤林俊介、竹本充
  • Journal Title: 日本整形外科学会雑誌 Vol.83 Pages: 469-474
  • Peer Reviewed
• [Journal Article] 腰椎固定術用チタン多孔体インプラントの開発と臨床試験プロトコル作成の経験から学んだこと (2009)
  • Author(s): 竹本充、藤林俊介、根尾昌志、太田雅人、中村孝志
  • Journal Title: 日本脊椎脊髄病学会雑誌 Vol.20 Pages: 215-215
  • Peer Reviewed
• [Journal Article] A new cementless total hip arthroplasty with bioactive titanium porous-coating by alkaline and heat treatment: average 4. 8-year results. (2009)
  • Author(s): Kawanabe K, Ise K, Goto K, Akiyama H, Nakamura T, Kaneuji A, Sugimori T, Matsumoto T.
  • Journal Title: J Biomed Mater Res B Appl Biomater. 90(1) Pages: 476-81
  • Peer Reviewed
• [Journal Article] 0-C2 angle as a predictor of dyspnea and/or dysphagia after occipitoce rvical fusion (2009)
  • Author(s): Miyata M., et al.
  • Journal Title: Spine 34 Pages: 194-188
  • Peer Reviewed
• [Journal Article] EP4 agonist accelerates osteoinduction and degradation of b-tricalcium phosphate by stimulating osteoclastogenesis (2009)
  • Author(s): Nasu T, et al
  • Journal Title: J. Biomed. Mater. Res. 89A Pages: 601-608
  • Peer Reviewed
• [Journal Article] Subaxial subluxation after atlantoaxial transarticular screw fixation in rheumatoid patients (2009)
  • Author(s): Ito H., et al
  • Journal Title: European Spine Journal 18 Pages: 869-876
  • Peer Reviewed
• [Journal Article] AWガラスセラミック多孔体の気孔構造による骨形成への影響 (2009)
  • Author(s): 斉藤聡彦, 他
  • Journal Title: Orthopaedic Ceramic Implants 29 Pages: 9-11
• [Journal Article] 機械的破損とその対策1)脊椎インプラント (2009)
  • Author(s): 根尾昌志, 他
  • Journal Title: 整形外科 60 Pages: 886-893
  • Peer Reviewed
• [Journal Article] Navigated anterior approach to the upper cervical spine after occipito cervical fusion (2009)
  • Author(s): Neo M., et al
  • Journal Title: Spine 34
  • Peer Reviewed
• [Journal Article] 生体活性チタンの開発-臨床応用に向けての課題- (2009)
  • Author(s): 藤林俊介, 他
  • Journal Title: 日整会誌 83 Pages: 469-474
  • NAID: 10026310720
• [Journal Article] (2009)
  • Author(s): 藤林俊介
  • Journal Title: OS Now Instruction(メジカルビュー社) Pages: 126-135
• [Journal Article] Osteoarthritis-Total Hip Replacement Clinical Study Team. Effects of ghrelin treatment on patients undergoing total hip replacement for osteoarthritis: different outcomes from studies in patients with cardiac and pulmonary cachexia. (2008)
  • Author(s): Akamizu T, Iwakura H, Ariyasu H, Murayama T, Sumi E, Teramukai S, Goto K, Ohnishi E, Akiyama H, Kawanabe K, Nankaku M, Ichihashi N, Tsuboyama T, Tamai K, Kataoka M, Nakamura T, Kangawa K
  • Journal Title: J Am Geriatr Soc. 56(12) Pages: 2363-5
  • Peer Reviewed
• [Journal Article] Onishi E, Enhancement of bone-bonding ability of bioactive titanium by prostaglandin E2 receptor selective agonist. (2008)
  • Author(s): Fujibayashi S, Takemoto M, Neo M, Maruyama T, Kokubo T, Nakamura T.
  • Journal Title: Biomaterials. 29(7) Pages: 877-83
  • Peer Reviewed
• [Journal Article] Stand-alone interbody cage versus anterior cervical plate for treatment of cervical disc herniation : sequential changes in cage subsidence (2008)
  • Author(s): Fujibayashi S, et al.
  • Journal Title: J Clin Neurosci 15 Pages: 1017-22
  • Peer Reviewed
• [Journal Article] Atlantoaxial transarticular screw fixation with posterior wiring using polyethylene cable : facet fusion despite posterior graft resorption in rheumatoid patients (2008)
  • Author(s): Ito H, et al.
  • Journal Title: Spine 33 Pages: 1655-61
  • Peer Reviewed
• [Journal Article] Enhancement of bone-bonding ability of bioactive titanium by prostaglandin E2 receptor selective agonist (2008)
  • Author(s): Onishi E, et al.
  • Journal Title: Biomaterials 29 Pages: 877-83
  • Peer Reviewed
• [Journal Article] Mechanical, setting, and biological properties of bone cements containing micron-sized titania particles (2008)
  • Author(s): Goto K, et al.
  • Journal Title: Mater Sci Mater Med 19 Pages: 1009-16
  • Peer Reviewed
• [Journal Article] Osteoarthritis-Total Hip Replacement Clinical Study Team. Effects of ghrelin treatment on patients undergoing total hip replacement for osteoarthritis : different outcomes from studies in patients with cardiac and pulmonary cachexia (2008)
  • Author(s): Akamizu T, et al.
  • Journal Title: J Am Geriatr Soc 56 Pages: 2363-5
  • Peer Reviewed
• [Journal Article] Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass (2008)
  • Author(s): Nakanishi R, et al.
  • Journal Title: J Bone Miner Res 23 Pages: 271-7
  • Peer Reviewed
• [Journal Article] PET fiber fabrics modified with bioactive titanium oxide for bone substitutes. (2008)
  • Author(s): Kokubo T, et. al.
  • Journal Title: J Mater Sci Mater Med 19 Pages: 695-702
  • Peer Reviewed
• [Journal Article] Enhancement of bone-bonding ability of bioactive titanium by prostaglandin E2 receptor selective agonist. (2008)
  • Author(s): Onishi E, et. al.
  • Journal Title: Biomaterials 29 Pages: 877-883
  • Peer Reviewed
• [Journal Article] A porous bioactive titanium implant for spinal interbody fusion: an experimental study using a canine model. (2007)
  • Author(s): Takemoto M, Fujibayashi S, Neo M, So K, Akiyama N, Matsushita T, Kokubo T, Nakamura T.
  • Journal Title: J Neurosurg Spine. 7(4) Pages: 435-43
  • Peer Reviewed
• [Journal Article] 生体活性チタン (2007)
  • Author(s): 藤林俊介、竹本充、大槻文悟、秋山典宏、根尾昌志、川那辺圭一、中村孝志
  • Journal Title: 日本整形外科学会雑誌 Vol.81,S21
  • Peer Reviewed
• [Journal Article] 生体活性処理焼結ポーラスチタンにおける骨伝導能と骨誘導能 (2007)
  • Author(s): 竹本充、藤林俊介、根尾昌志、秋山典宏、小久保正、中村孝志
  • Journal Title: 日本整形外科学会雑誌 Vol.81,S859
  • Peer Reviewed
• [Journal Article] A porous bioactive titanium implant for spinal interbody fusion: an experimental study using a canine model. (2007)
  • Author(s): Takemoto M, et. al.
  • Journal Title: J Neurosurg Spine 7 Pages: 435-43
  • Peer Reviewed
• [Journal Article] Novel micro-CT based 3-dimensional structural analyses of porous biomaterials. (2007)
  • Author(s): Otsuki B, et. al.
  • Journal Title: Bioceramics 19 330-332 Pages: 967-70
  • Peer Reviewed
• [Journal Article] Surface modification of organic polymers with bioactive titanium oxide without the aid of a silane-coupling agent. (2007)
  • Author(s): Balas F, et. al.
  • Journal Title: J Mater Sci Mater Med 18 Pages: 1167-1174
  • Peer Reviewed
• [Journal Article] In vivo evaluation of a porous hydroxyapatite/poly-DL-lactide composite for bone tissue engineering. (2007)
  • Author(s): Hasegawa S, et. al.
  • Journal Title: J Biomed Mater Res A 81 Pages: 930-938
  • Peer Reviewed
• [Journal Article] Efficacy of computer-assisted pedicle screw insertion for cervical instability in RA patients. (2007)
  • Author(s): Ito H, et. al.
  • Journal Title: Rheumatol Int 27 Pages: 567-574
  • Peer Reviewed
• [Presentation] ガラスセラミックAW多孔体の骨誘導能と気孔構造による骨誘導能への影響 (2009)
  • Author(s): 斉藤聡彦, 他
  • Organizer: 第29回整形外科セラミック・インプラント研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-12-12
• [Presentation] Osteoinductive Ti metal: Development and clinical applications. (2009)
  • Author(s): Takemoto M, Fujibayashi S, Matsushita T, Kokubo T, Nakamura T
  • Organizer: Biomaterials Asia 2009
  • Place of Presentation: Hong Kong, China
• [Presentation] 腰椎固定術用チタン多孔体インプラントの開発と臨床試験プロトコル作成の経験から学んだこと (2009)
  • Author(s): 竹本充、藤林俊介、根尾昌志、太田雅人、中村孝志
  • Organizer: 第38回日本脊椎脊髄病学会
  • Place of Presentation: 神戸
• [Presentation] 後頭骨頚椎固定術における0-C2角の重要性術後の嚥下困難や上気道閉塞を回避するために (2009)
  • Author(s): 宮田誠彦, 他
  • Organizer: 第38回日本脊椎脊髄病学会
  • Place of Presentation: 神戸
• [Presentation] S1椎弓根スクリュー設置における傍脊柱筋間アプローチの有用性正中アプローチとの比較による検討 (2009)
  • Author(s): 太田雅人, 他
  • Organizer: 第38回日本脊椎脊髄病学会
  • Place of Presentation: 神戸
• [Presentation] RA頚椎症ではMagerl螺子やC2椎弓根螺子の刺入が困難であることが多い (2009)
  • Author(s): 宮田誠彦, 他
  • Organizer: 第38回日本脊椎脊髄病学会
  • Place of Presentation: 神戸
• [Presentation] 抗生剤入り骨セメントを用いた難治性脊椎感染症に対する治療 (2009)
  • Author(s): 藤林俊介, 他
  • Organizer: 第38回日本脊椎脊髄病学会
  • Place of Presentation: 神戸
• [Presentation] 脳外科用ナビゲーションシステムの上位頚椎前方アプローチへの応用 (2009)
  • Author(s): 根尾昌志, 他
  • Organizer: 第38回日本脊椎脊髄病学会
  • Place of Presentation: 神戸
• [Presentation] 低侵襲paraspinal TLIFの有効性従来法との比較による検討 (2009)
  • Author(s): 藤林俊介, 他
  • Organizer: 第38回日本脊椎脊髄病学会
  • Place of Presentation: 神戸
• [Presentation] urgical treatment for retroodontoid psudotumors : is routine occipitoce rvical fusion necessary? (2009)
  • Author(s): Takemoto M
  • Organizer: 25^h Annual Meeting of Cervical Spine Research Society European Section
  • Place of Presentation: Sweden
• [Presentation] -C2 angle impacts on dyspnea/dysphagia after O-C fusion (2009)
  • Author(s): Neo M
  • Organizer: 25^h Annual Meeting of Cervical Spine Research Society European Section
  • Place of Presentation: Sweden
• [Presentation] S1椎弓根スクリュー設置に対する傍脊柱筋間アプローチの有用性 (2009)
  • Author(s): 太田雅人, 他
  • Organizer: 第16回日本脊椎脊髄神経手術手技学会
  • Place of Presentation: 東京
• [Presentation] 胸腰椎固定におけるインプラント破損反省と対策 (2009)
  • Author(s): 根尾昌志, 他
  • Organizer: 第16回日本脊椎脊髄神経手術手技学会
  • Place of Presentation: 東京
• [Presentation] 酸化チタン被覆PETの骨結合能に関する研究 (2009)
  • Author(s): 斉藤聡彦, 他
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 横浜
• [Presentation] 骨髄液のscaffoldとして多孔体戦複合体u-HA/PDLLAを用いたウサギ腰椎後側方固定術の検討 (2009)
  • Author(s): 田中耕次郎, 他
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 横浜
• [Presentation] Clinical Application and future possible applications of alkali and heat treated Ti Metal (2008)
  • Author(s): Nakamura T
  • Organizer: 21st International Symposium of Ceramics in Medicine
  • Place of Presentation: ブラジル
  • Year and Date: 2008-10-22
• [Presentation] バイオマテリアルによる骨再生「チタン金属による骨再生」 (2008)
  • Author(s): 藤林俊介
  • Organizer: 第26回日本骨代謝学会学術集会ミニシンポジウム
  • Place of Presentation: 大阪
• [Presentation] A novel biomaterial for spinal fusion: An experimental study in a canine lumbar interbody fusion model (2008)
  • Author(s): M. Takemoto, S. Fujibayashi, M. Neo, T. Nakamura
  • Organizer: Spineweek 2008
  • Place of Presentation: Eurospine, Geneva, Switzerland
• [Presentation] バイオマテリアルそのものによる骨形成 (2007)
  • Author(s): 中村 孝志、他
  • Organizer: 第29回日本バイオマテリアル学会大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-26
• [Presentation] ポーラスチタン材料における多孔構造及び表面性状が骨内、筋肉内での骨形成に与える影響について (2007)
  • Author(s): 竹本 充、他
  • Organizer: 第141回日本金属学会シンポジウム
  • Place of Presentation: 岐阜
  • Year and Date: 2007-09-19
• [Presentation] 生体活性処理焼結ポーラスチタンにおける骨伝導能と骨誘導能 (2007)
  • Author(s): 竹本充、藤林俊介、根尾昌志、秋山典宏、小久保正、中村孝志
  • Organizer: 第22回日本整形外科学会基礎学術集会
  • Place of Presentation: 浜松
• [Presentation] 生体活性チタン (2007)
  • Author(s): 藤林俊介、竹本充、大槻文悟、秋山典宏、根尾昌志、川那辺圭一、中村孝志
  • Organizer: 第80回日本整形外科学会学術総会
  • Place of Presentation: 神戸
• [Remarks] 2009.1.6新聞各紙での臨床試験に関する報道(共同通信、産経新聞、毎日新聞、京都新聞)
• [Remarks] 2009.1.6読売テレビ・イブニングニュースでの臨床試験に関する報道
• [Remarks] 2009.2.11テレビ大阪News Biz「特集腰痛治療最前線」
• [Remarks] 2009.2.20週刊ポスト「第149回医心伝身」腰椎変性疾患による腰痛に多孔体チタン製人工骨手術
• [Patent(Industrial Property Rights)] 人工骨の製造方法 (2007)
  • Inventor(s): 中村孝志藤林俊介, 他3名
  • Industrial Property Rights Holder: 京都大学中部大学佐川印刷株式会社
  • Filing Date: 2007-03-16
• [Patent(Industrial Property Rights)] 人工骨の製造方法 (2007)
  • Inventor(s): 中村孝志藤林俊介, 他3名
  • Industrial Property Rights Holder: 京都大学中部大学佐川印刷株式会社
  • Industrial Property Number: 2008-511947
  • Filing Date: 2007-03-16
• [Patent(Industrial Property Rights)] 生体インプラント材料の製造方法 (2006)
  • Inventor(s): 小久保正中村孝志金鉉敏
  • Industrial Property Rights Holder: 財団法人イオン工学振興財団
  • Filing Date: 2006-11-10
• [Patent(Industrial Property Rights)] 生体骨誘導性の人工骨とその製造方法 (2004)
  • Inventor(s): 中村孝志小久保正, 他3名
  • Industrial Property Rights Holder: 関西TLO株式会社
  • Industrial Property Number: 2005-507965
  • Filing Date: 2004-01-07
• [Patent(Industrial Property Rights)] 生体骨誘導性の人工骨とその製造方法 (2004)
  • Inventor(s): 中村孝志小久保正, 他3名
  • Industrial Property Rights Holder: 関西TLO株式会社
  • Filing Date: 2004-01-07
• [Patent(Industrial Property Rights)] 生体親和性に優れた骨代替材料およびその製造方法 (2002)
  • Inventor(s): 小久保正中村孝志, 他4名
  • Industrial Property Rights Holder: 小久保正中村孝志, 他2名
  • Industrial Property Number: 2002-302167
  • Filing Date: 2002-10-16