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Phytochemical genomics : Genomic basis for phytochemical diversity

Research Project

Project/Area Number 19201043
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionChiba University

Principal Investigator

SAITO Kazuki  Chiba University, 大学院・薬学研究院, 教授 (00146705)

Co-Investigator(Kenkyū-buntansha) YAMAZAKI Mami  千葉大学, 大学院・薬学研究院, 准教授 (70222370)
YOSHIMOTO Naoko  千葉大学, 大学院・薬学研究院, 助教 (10415333)
NOJI Masaaki  徳島文理大学, 生薬研究所, 准教授 (80271534)
TAKAYAMA Hiromitsu  千葉大学, 大学院・薬学研究院, 教授 (90171561)
KANAYA Shigehiko  奈良先端科学技術大学院大学, 情報科学研究科, 教授 (90224584)
KUSANO MIYAKO  独立行政法人理化学研究所, 植物科学研究センター, 研究員 (60415148)
Co-Investigator(Renkei-kenkyūsha) NAKABAYASHI Ryo  独立行政法人理化学研究所, 植物科学研究センター, 特別研究員 (30586160)
AOKI Toshio  日本大学, 生物資源学部, 准教授 (80287606)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000)
Fiscal Year 2010: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2009: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2008: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2007: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Keywords植物成分 / 二次代謝産物 / メタボロミクス / トランスクリプトミクス / ゲノム機能学 / 生合成 / フラボノイド / シロイヌナズナ / 薬用植物 / アルカロイド / システイン / ゲノム機能科学
Research Abstract

Plants produce over 200,000 chemical compounds, which are used as the sources of medicines, foods, industrial and energy materials in our daily life. In this project, we have investigated the genomic basis for the production of these plant products by means of metabolomics and transcriptomics. We have identified genes involved in the production of flavonoids, sulfur-containing metabolites and alkaloids, which exhibit health-beneficial activities. We have also elucidated the metabolic networks for the production of these compounds.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (88 results)

All 2011 2010 2009 2008 2007 Other

All Journal Article (41 results) (of which Peer Reviewed: 35 results) Presentation (32 results) Book (4 results) Remarks (11 results)

  • [Journal Article] Molecular genetic study on the anthocyanins chemotypes of Perilla frutescens var.2011

    • Author(s)
      Mami Yamazaki, Kazuki Saito
    • Journal Title

      crispa.Nat.Prod.Commun. 6

      Pages: 423-427

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] An acyltransferase-like gene obtained by differential gene expression profiles of quinolizidine alkaloid-producing and nonproducing cultivars of Lupinus angustifolius.2011

    • Author(s)
      Somnuk Bunsupa, Taketo Okada, Kazuki Saito, Mami Yamazaki
    • Journal Title

      Plant Biotech. 28

      Pages: 89-94

    • NAID

      10028258703

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] An acyltransferase-like gene obtained by differential gene expression profiles of quinolizidine alkaloid-producing and nonproducing cultivars of Lupinus angustifolius.2011

    • Author(s)
      Somnuk Bunsupa, Taketo Okada, Kazuki Saito, Mami Yamazaki
    • Journal Title

      Plant Biotech.

      Volume: 28 Pages: 89-94

    • NAID

      10028258703

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular genetic study on the anthocyanins chemotypes of Perilla frutescens var.crispa.2011

    • Author(s)
      Mami Yamazaki, KazukiSaito
    • Journal Title

      Nat.Prod Commun.

      Volume: 6 Pages: 423-427

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A polyhedral approach including natural products chemistry for understanding flavonoid biosynthesis in Arabidopsis.2010

    • Author(s)
      Ryo Nakabayashi, Mami Yamazaki, Kazuki Saito
    • Journal Title

      New Biotechnology 27

      Pages: 829-836

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomics for functional genomics, systems biology, and biotechnology.2010

    • Author(s)
      Kazuki Saito, Fumio Matsuda
    • Journal Title

      Annu.Rev.Plant Biol. 61

      Pages: 463-489

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Supaart Sirikantaramas, Hiroshi Sudo and Kazuki Saito : Biosynthetic system of camptothecin: an anticancer plant product.2010

    • Author(s)
      Mami Yamazaki, Takashi Asano, Yasuyo Yamazaki
    • Journal Title

      Pure Appl.Chem. 82

      Pages: 213-218

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The coevolution of the camptothecin biosynthetic pathway and self-resistance mechanism.2010

    • Author(s)
      Supaart Sirikantaramas, Mami Yamazaki, Kazuki Saito
    • Journal Title

      Phytochemistry 70

      Pages: 1894-1898

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] General regulatory patterns of plant mineral nutrient depletion as revealed by serat quadruple mutants disturbed in cysteine synthesis.2010

    • Author(s)
      Mutsumi Watanabe, Hans-Michael Hubberten, Kazuki Saito, Rainer Hoefgen
    • Journal Title

      Mol.Plant 3

      Pages: 438-466

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthetic system of camptothecin : an anticancer plant product.2010

    • Author(s)
      Mami Yamazaki, Takashi Asano, Yasuyo Yamazaki, Supaart Sirikantaramas, Hiroshi Sudo, Kazuki Saito
    • Journal Title

      Pure Appl.Chem. 82

      Pages: 213-218

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthetic system of camptothecin : an anticancer plant product.2010

    • Author(s)
      Mami Yamazaki, Takashi Asano, Yasuyo Yamazaki, Supaart Sirikantaramas, Hiroshi Sudo, Kazuki Saito
    • Journal Title

      Pure Appl.Chem.

      Volume: 82 Pages: 213-218

    • Related Report
      2010 Annual Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomics for functional genomics, systems biology, and biotechnology.2010

    • Author(s)
      Kazuki Saito, Fumio Matsuda
    • Journal Title

      Annu.Rev.Plant Biol.

      Volume: 61 Pages: 463-489

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A polyhedral approach including natural products chemistry for understanding flavonoid biosynthesis in Arabidopsis.2010

    • Author(s)
      Ryo Nakabayashi, Mami Yamazaki, Kazuki Saito
    • Journal Title

      New Biotechnology

      Volume: 27 Pages: 829-836

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthetic system of camptothecin : an anticancer plant product2010

    • Author(s)
      Mami Yamazaki, Takashi Asano, Yasuyo Yamazaki, Supaart Sirikantaramas, Hiroshi Sudo, Kazuki Saito
    • Journal Title

      Pure Appl. Chem. 82

      Pages: 213-218

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] General regulatory patterns of plant mineral nutrient depletion as revealed by serat quadruple mutants disturbed in cysteine synthesis.2010

    • Author(s)
      Mutsumi Watanabe, Hans-Michael Hubberten, Kazuki Saito, Rainer Hoefgen
    • Journal Title

      Mol.Plant

      Volume: 3 Pages: 438-466

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] the coevolution of the camptothecin biosynthetic pathway and self-resistance mechanism.2010

    • Author(s)
      Supaart Sirikantaramas, Mami Yamazaki, Kazuki Saito
    • Journal Title

      Phytochemistry

      Volume: 70 Pages: 1894-1898

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomics-oriented isolation and structure elucidation of 37 compounds including two new anthocyanins from Arabidopsis thaliana.2009

    • Author(s)
      Ryo Nakabayashi, Miyako Kusano, Makoto Kobayashi, Takayuki Tohge, Keiko Yonekura-Sakakibara, Noriyuki Kogure, Mami Yamazaki, Mariko Kitajima, Kazuki Saito, Hiromitsu Takayama
    • Journal Title

      Phytochemistry 70

      Pages: 1017-1029

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of adenosine-5'-phosphosulphate kinase. in Arabidopsis reduces levels of sulphated secondary metabolites.2009

    • Author(s)
      Sarah G. Mugford, Naoko Yoshimoto, Michael Reichelt, Markus Wirtz, Lionel Hill, Sam T. Mugford, Yoshimi Nakazato, Masaaki Noji, Hideki Takahashi, Robert Kramell, Tamara Gigolashvili, Ulf-Ingo Flugge, Claus Wasternack, Jonathan Gershenzon, Rudiger Hell, Kazuki Saito, Stanislav Kopriva
    • Journal Title

      Plant Cell 21

      Pages: 910-927

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomics-oriented isolation and structure elucidation of 37 compounds including two new anthocyanins from Arabidopsis thaliana2009

    • Author(s)
      Ryo Nakabayashi, Miyako Kusano, Makoto Kobayashi, Takayuki Tohge, Keiko Yonekura-Sakakibara, Noriyuki Kogure, Mami Yamazaki, Mariko Kitajima, Kazuki Saito, Hiromitsu Takayama
    • Journal Title

      Phytochemistry 70

      Pages: 1017-1029

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Disruption of adenosine-5'-phosphosulphate kinase in Arabidopsis reduces levels of sulphated secondary metabolites.2009

    • Author(s)
      Sarah G.Mugford, Naoko Yoshimoto, Michael Reichelt, Markus Wirtz, Lionel Hill, Sam T.Mugford, Yoshimi Nakazato, Masaaki Noji, Hideki Takahashi, Robert Kramell, Tamara Gigolashvili, Ulf-Ingo Flugge, Claus Wasternack, Jonathan Gershenzon, Rudiger Hell, Kazuki Saito, Stanislav Kopriva
    • Journal Title

      Plant Cell

      Volume: 21 Pages: 910-927

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomics-oriented isolation and structure elucidation of 37 compounds including two new anthocyanins from Arabidopsis thaliana.2009

    • Author(s)
      Ryo Nakabayashi, Miyako Kusano, Makoto Kobayashi, Takayuki Tohge, Keiko Yonekura-Sakakibara, Noriyuki Kogure, Mami Yamazaki, Mariko Kitajima, Kazuki Saito, Hiromitsu Takayama
    • Journal Title

      Phytochemistry

      Volume: 70 Pages: 1017-1029

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis.2008

    • Author(s)
      Mutsumi Watanabe, Keiichi Mochida, Tomohiko Kato, Satoshi Tabata, Naoko Yoshimoto, Masaaki Noji, Kazuki Saito
    • Journal Title

      Plant Cell 20

      Pages: 2484-2496

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential gene expression profiles of red and green forms of Perilla frutescens leading to comprehensive identification of anthocyanin biosynthetic genes.2008

    • Author(s)
      Mami Yamazaki, Masahisa Shibata, Yasutaka Nishiyama, Karin Springob, Masahiko Kitayama, Norimoto Shimada, Toshio Aoki, Shin-ichi Ayabe, Kazuki Saito
    • Journal Title

      FEBS J. 275

      Pages: 3494-3502

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants.2008

    • Author(s)
      Supaart Sirikantaramas, Mami Yamazaki, Kazuki Saito
    • Journal Title

      Proc.Natl.Acad.Sci.USA 105

      Pages: 6782-6786

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive Flavonol Profiling and Transcriptome Coexpression Analysis Leading to Decoding Gene-Metabolite Correlation in Arabidopsis.2008

    • Author(s)
      Keiko Yonekura-Sakakibara, Takayuki Tohge, Fumio Matsuda, Ryo Nakabayashi, Hiromitsu Takayama, Rie Niida, Akiko Watanabe-Takahashi, Eri Inoue, Kazuki Saito
    • Journal Title

      Plant Cell 20

      Pages: 2160-2176

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of PAP1-upregulated Glutathione S-transferase genes in Arabidopsis thaliana.2008

    • Author(s)
      Bunyapa Wangwattana, Yoko Koyama, Yasutaka Nishiyama, Masahiko Kitayama, Mami Yamazaki, Kazuki Saito
    • Journal Title

      Plant Biotechnology 25

      Pages: 191-196

    • NAID

      10021913113

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physiological roles of the ・-substituted alanine synthase gene family in Arabidopsis.2008

    • Author(s)
      Mutsumi Watanabe, Miyako Kusano, Akira Oikawa, Atsushi Fukushima, Masaaki Noji, Kazuki Saito
    • Journal Title

      Plant Physiol. 146

      Pages: 310-320

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physiological roles of the ・-substituted alanine synthase gene family in Arabidopsis2008

    • Author(s)
      Mutsumi Watanabe, Miyako Kusano, Akira Oikawa, Atsushi Fukushima, Masaaki, Kazuki Saito
    • Journal Title

      Plant Physiol. 146

      Pages: 310-320

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants2008

    • Author(s)
      Supaart Sirikantaramas, Mami Yamazaki, Kazuki Saito
    • Journal Title

      Proc. Natl. Acad. Sci. USA 105

      Pages: 6782-6786

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Differential gene expression profiles of red and green forms of Perilla frutescens leading to comprehensive identification of anthocyanin biosynthetic genes2008

    • Author(s)
      Mami Yamazaki, Masahisa Shibata, Yasutaka Nishiyama, Karin Springob, Masahiko Kitayama, Norimoto Shimada, Toshio Aoki, Shin-ichi Ayabe, Kazuki Saito
    • Journal Title

      FEBS J. 275

      Pages: 3494-3502

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis2008

    • Author(s)
      Mutsumi Watanabe, Keiichi Mochida, Tomohiko Kato, Satoshi Tabata, Naoko Yoshimoto, Masaaki Noji, Kazuki Saito
    • Journal Title

      Plant Cell 20

      Pages: 2484-2496

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Characterization of PAP1-upregulated Glutathione S-transferase genes in Arabidopsis thaliana2008

    • Author(s)
      Bunyapa Wangwattana, Yoko Koyama, Yasutaka Nishiyama, Masahiko Kitayama, Mami Yamazaki, Kazuki Saito
    • Journal Title

      Plant Biotechnology 25

      Pages: 191-196

    • NAID

      10021913113

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive Flavonol Profiling and Transcriptome Coexpression Analysis Leading to Decoding Gene-Metabolite Correlation in Arabidopsis2008

    • Author(s)
      Keiko Yonekura-Sakakibara, Takayuki Tohge, Fumio Matsuda, Ryo Nakabayashi, Hiromitsu Takayama, Rie Niida, Akiko Watanabe-Takahashi, Eri Inoue, Kazuki Saito
    • Journal Title

      The Plant Cell 20

      Pages: 2160-2176

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative Genomics and Reverse Genetics Analysis Reveal Indispensable Functions of the Serine Acetyltransferase Gene Family in Arabidopsis2008

    • Author(s)
      Mutsumi Watanabe, Keiichi Mochida, Tomohiko Kato, Satoshi Tabata, Naoko Yoshimoto, Masaaki Noji, Kazuki Saito
    • Journal Title

      The Plant Cell 20

      Pages: 2484-2496

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiological roles of the β-substituted alanine synthase gene famil family in Arabidopsis2008

    • Author(s)
      Mutsumi Watanabe, Miyako Kusano, Akira Oikawa, Atsushi Fukushima, Masaaki Noji, and Kazuki Saito
    • Journal Title

      Plant Physiol 146

      Pages: 310-320

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Convergent evolution in the BAHD family of acyl transferases ; identification and characterisation of anthocyanin acyl transferases from Arabidopsis thaliana.2007

    • Author(s)
      Jie Luo, Yasutaka Nishiyama, Christine Fuell, Goro Taguchi, Katherine Elliott, Lionel Hill, Yoshikazu Tanaka, Masahiko Kitayama, Mami Yamazaki, Paul Bailey, Adrian Parr, Anthony J.Michael, Kazuki Saito, Cathie Martin
    • Journal Title

      Plant J. 50

      Pages: 678-695

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transport of camptothecin in hairy roots of Ophiorrhiza pumila.2007

    • Author(s)
      Supaart Sirikantaramas, Hiroshi Sudo, Takashi Asano, Mami Yamazaki, Kazuki Saito
    • Journal Title

      Phytochemistry 68

      Pages: 2881-2886

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a flavonol 7-O-rhamnosyltransferase gene determining flavonoid pattern in Arabidopsis by transcriptome coexpression and reverse genetics.2007

    • Author(s)
      Keiko Yonekura-Sakakibara, Takayuki Tohge, Rie Niida, Kazuki Saito
    • Journal Title

      J.Biol.Chem. 282

      Pages: 14932-14941

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a flavonol 7-O-rhamnosyltransferase gene determining flavonoid pattern in Arabidopsis by transcriptome coexpression and reverse genetics2007

    • Author(s)
      Keiko Yonekura-Sakakibara, Takayuki Tohge, Rie Niida, and Kazuki Saito
    • Journal Title

      J.Biol Chem 282

      Pages: 14932-14941

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transport of camptothecin in hairy roots of Ophiorrhiza pumila2007

    • Author(s)
      Supaart Sirikantaramas, Hiroshi Sudo, Takashi Asano, Mami Yamazaki, and Kazuki Saito
    • Journal Title

      Phytochemistry 68

      Pages: 2881-2886

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Convergent evolution in the BAHD family of acyl transferases;identification and characterisation of anthocyanin acyl transferases from Arabidopsis thaliana2007

    • Author(s)
      Jie Luo, Yasutaka Nishiyama, Christine Fuell, Goro Taguchi, Katherine Elliott, Lionel Hill, Yoshikazu Tanaka, Masahiko Kitayama, Mami Yamazaki, Paul Bailey, Adrian Parr, Anthony J. Michael, Kazuki Saito and Cathie Marthin
    • Journal Title

      Plant J 50

      Pages: 678-695

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Plant metabolomics for systems biology and crop biotechnology.2010

    • Author(s)
      斉藤和季
    • Organizer
      Cold Spring Harbor Asia conference From Plant Biology to Crop Biotechnology.
    • Place of Presentation
      Suzhou, China
    • Related Report
      2010 Final Research Report
  • [Presentation] Omics-based understanding of biosynthetic systems of plant specialized products.2010

    • Author(s)
      斉藤和季
    • Organizer
      European Plant Science Organisation. 5t^<th> EPSO Conference 'Plant for Life'
    • Place of Presentation
      Kittila (Lapland), Finland
    • Related Report
      2010 Final Research Report
  • [Presentation] Plant metabolomics for systems biology-From Arabidopsis to crops.2010

    • Author(s)
      斉藤和季
    • Organizer
      21^<st> International Conference on Arabidopsis Research.
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] メタボロミクスを基盤としたファイトケミカルゲノミクス2010

    • Author(s)
      斉藤和季
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Plant metabolomics for systems biology-From Arabidopsis to crops.2010

    • Author(s)
      K.Saito
    • Organizer
      21^<st> International Conference on Arabidopsis Research
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Omics-based understanding of biosynthetic systems of plant specialized products.2010

    • Author(s)
      K.Saito
    • Organizer
      European Plant Science Organisation.5^<th> EPSO Conference Plant for Life
    • Place of Presentation
      Kittila (Lapland), Finland
    • Related Report
      2010 Annual Research Report
  • [Presentation] Plant metabolomics for systems biology and crop biotechnology.2010

    • Author(s)
      K.Saito
    • Organizer
      Cold Spring Harbor Asia conference From Plant Biology to Crop Biotechnology
    • Place of Presentation
      Suzhou, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] シロイヌナズナにおける二つのMYB遺伝子同時過剰発現による遺伝子発現及びフラボノイド蓄積への効果2009

    • Author(s)
      中林亮,榊原圭子,松田史生,峠隆之,北島満里子,高山廣光,山崎真巳,斉藤和季
    • Organizer
      第4回メタボロームシンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Why plants can resist their own deadly metabolites : Coevolution of specialized toxin-producing pathway and self-resistance mechanism.2009

    • Author(s)
      S.Sirikantaramas, M.Yamazaki, K.Saito
    • Organizer
      9th International Plant Molecular Biology Congress.
    • Place of Presentation
      St. Louis, Missouri, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Metabolomics-based functional genomics-From Arabidopsis and beyond.2009

    • Author(s)
      斉藤和季
    • Organizer
      Metabolomics Society's 5th Annual International Conference.
    • Place of Presentation
      Edmonton, Canada
    • Related Report
      2010 Final Research Report
  • [Presentation] TDCi毛状根の代謝物変動解析に基づくカンプトテシン生合成中間体の探索2009

    • Author(s)
      小林可菜英,浅野孝,佐々木亮介,飯島陽子,青木考,柴田大輔,斉藤和季,山崎真巳
    • Organizer
      第27回日本植物細胞分子生物学会(藤沢)大会・シンポジウム
    • Place of Presentation
      藤沢
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] シロイヌナズナにおける硫黄同化酵素ATPスルフリラーゼの機能解析2009

    • Author(s)
      吉本尚子,東泰弘,勝沼咲子,水野新也,高橋秀樹,野路征昭,斉藤和季
    • Organizer
      第27回日本植物細胞分子生物学会(藤沢)大会・シンポジウム
    • Place of Presentation
      藤沢
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Why plants can resist their own deadly metabolites : Coevolution of specialized toxin-producing pathway and self-resistance mechanism2009

    • Author(s)
      S. Sirikantaramas, M. Yamazaki, K. Saito
    • Organizer
      9th International Plant Molecular Biology Congress
    • Place of Presentation
      St. Louis, Missouri, USA.
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Metabolomics-based functional genomics-From Arabidopsis and beyond2009

    • Author(s)
      K. Saito
    • Organizer
      Metabolomics Society's 5th Annual International Conference
    • Place of Presentation
      Edmonton, Canada
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 二つのMYB遺伝子の同時過剰発現体におけるトランスクリプトームとフラボノイドプロファイル2008

    • Author(s)
      中林亮,榊原圭子,松田史生,北島満里子,高山廣光,山崎真巳,斉藤和季
    • Organizer
      第26回日本植物細胞分子生物学会大阪大会・シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] UDP-糖供給系がフラボノイド代謝系に及ぼす影響2008

    • Author(s)
      榊原圭子,峠隆之,新井田理絵,高橋晶子,斉藤和季
    • Organizer
      第26回日本植物細胞分子生物学会大阪大会・シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Flavonoid profiling and transcriptome in Arabidopsis overexpressing two MYB genes.2008

    • Author(s)
      R.Nakabayashi, K.Yonekura-Sakakibara, F.Matsuda, T.Tohge, M.Kitajima, H.Takayama, M.Yamazaki, K.Saito
    • Organizer
      5^<th> International Conference on Plant Metabolomics.
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Characterization of transcription factor expressed in camptothecin producing hairy roots.2008

    • Author(s)
      M.Yamazaki, J.Okuyama, T.Asano, K.Saito
    • Organizer
      5^<th> International Conference on Plant Metabolomics.
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Integration of metabolomics and transcriptomics for phytochemcal genomics in Arabidopsis and non-model plants.2008

    • Author(s)
      斉藤和季
    • Organizer
      The 1^<st> International Conference on Plant Secondary Metabolism.
    • Place of Presentation
      Kunming, China
    • Related Report
      2010 Final Research Report
  • [Presentation] Roles of gene families of O-acetylserine thiol-lyase and serine acetyltransferase in Arabidopsis : Just redundancy or hidden secret?.2008

    • Author(s)
      M.Watanabe, M.Kusano, A.Oikawa, A.Fukushima, M.Noji, K.Saito
    • Organizer
      7^<th> Workshop on Sulfur in Plants.
    • Place of Presentation
      Warsaw, Poland
    • Related Report
      2010 Final Research Report
  • [Presentation] Roles of gene families of O-acetylserine thiol-lyase and serine acetyltransferase in Arabidopsis : Just redundancy or hidden secret?2008

    • Author(s)
      M.Watanabe, M.Kusano, A.Oikawa, A.Fukushima, M.Noji, K.Saito
    • Organizer
      7^<th> Workshop on Sulfur in Plants
    • Place of Presentation
      Warsaw, Poland
    • Related Report
      2008 Annual Research Report
  • [Presentation] Integration of metabolomics and transcriptomics for phytochemcal genomics in Arabidopsis and non-model plants2008

    • Author(s)
      K.Saito
    • Organizer
      The 1^<st> International Conference on Plant Secondary Metabolism
    • Place of Presentation
      Kunming, China
    • Related Report
      2008 Annual Research Report
  • [Presentation] Flavonoid profiling and transcriptome in Arabidopsis overexpressing two MYB genes2008

    • Author(s)
      R.Nakabayashi, K.Yonekura-Sakakibara, F.Matsuda, T.Tohge, M.Kitajima, H.Takayama, M.Yamazaki, K.Saito
    • Organizer
      5^<th> International Conference on Plant Metabolomics
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Characterization of transcription factor expressed in camptothecin producing hairy roots2008

    • Author(s)
      M.Yamazaki, J.Okuyama, T.Asano, K.Saito
    • Organizer
      5^<th> International Conference on Plant Metabolomics
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Camptothecin biosynthetic system-Pathway elucidation, gene discovery and self-resistance.2007

    • Author(s)
      斉藤和季
    • Organizer
      PSE (Phytochemical Society of Europe) Congress. Plants for Human Health in the Post-Genome Era.
    • Place of Presentation
      Helsinki, Finland
    • Related Report
      2010 Final Research Report
  • [Presentation] Roles of gene families of O-acetylserine thiol-lyase and serine acetyltransferase in Arabidopsis : Just redundancy or hidden secret?2007

    • Author(s)
      M.Watanabe, M.Kusano, A.Oikawa, A.Fukushima, M.Noji, K.Saito
    • Organizer
      10^<th> International Congress on Amino Acids and Proteins.
    • Place of Presentation
      Chalkidiki, Greece
    • Related Report
      2010 Final Research Report
  • [Presentation] Phytochemical genomics in Arabidopsis thaliana and towards non-model plants. Integration of metabolomics and transcriptomics.2007

    • Author(s)
      斉藤和季
    • Organizer
      2007 Phytochemical Society of North America Annual Meeting.
    • Place of Presentation
      St.Louis, Missouri, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Integration of transcriptomics and metabolomics for finding regulatory networks in plant metabolism.2007

    • Author(s)
      斉藤和季
    • Organizer
      Gordon Research Conferences 'Plant Metabolic Engineering'.
    • Place of Presentation
      Tilton, New Hampshire, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Integration of transcriptomics and metabolomics for finding regulatory networks in plant metabolism.2007

    • Author(s)
      K. Saito
    • Organizer
      Gordon Research Conferences‘Plant Metabolic Engineering
    • Place of Presentation
      Tilton,New Hampshire,USA.
    • Related Report
      2007 Annual Research Report
  • [Presentation] Phytochemical genomics in Arabidopsis thaliana and towards non-model plants2007

    • Author(s)
      K. Saito
    • Organizer
      Integration of metabolomics and transcriptomics.2007 Phytochemical Society of North America Annual Meeting.
    • Place of Presentation
      St.Louis,Missouri,USA.
    • Related Report
      2007 Annual Research Report
  • [Presentation] Roles of gene families of O-acetylserine thiol-lyase and serine acetyltransferase in Arabidopsis:Just redundancy or hidden secret?2007

    • Author(s)
      M.Watanabe, M. Kusano, A. Oikawa, Atsushi Fukush ima, M. Noji, K. Saito
    • Organizer
      10th International Congress on Amino Acids and Proteins.
    • Place of Presentation
      Chalkidiki,Greece
    • Related Report
      2007 Annual Research Report
  • [Presentation] Camptothecin biosynthetic system-Pathway elucidation, genediscovery and self-resistance.2007

    • Author(s)
      K. Saito
    • Organizer
      PSE (Phytochemical Society of Europe)Congress.Plants for Human Health in the Post-Genome Era.
    • Place of Presentation
      Helsinki,Finland
    • Related Report
      2007 Annual Research Report
  • [Book] Comprehensive Natural Products II Chemistry and Biology(Mander, L., Lui, H.-W., eds.)(Production of Pharmaceuticals by Plant Tissue Cultures volume 3)2010

    • Author(s)
      Toshiya Muranaka, Kazuki Saito
    • Publisher
      Elsevier
    • Related Report
      2010 Final Research Report
  • [Book] Production of Pharmaceuticals by Plant Tissue Cultures.In(Comprehensive Natural Products II Chemistry and Biology)2010

    • Author(s)
      Toshiya Muranaka, KazukiSaito
    • Total Pages
      14
    • Publisher
      Elsevier : Oxford
    • Related Report
      2010 Annual Research Report
  • [Book] Methods in Molecular Biology 547. Protocols for In Vitro Cultures and Secondary Metabolite Analysis of Aromatic and Medicinal Plants(S.Mohan Jain and Praveen K.Saxena, eds)(Camptothecin production by in vitro cultures and plant regeneration in Ophiorrhiza species)2009

    • Author(s)
      Takashi Asano, Hiroshi Sudo, Mami Yamazaki, Kazuki Saito
    • Publisher
      Humana Press-Springer
    • Related Report
      2010 Final Research Report
  • [Book] Methods in Molecular Biology 547. Protocols for In Vitro Cultures and Secondary Metabolite Analysis of Aromatic and Medicinal Plants(S. Mohan Jain and Praveen K. Saxena, eds, Camptothecin production by in vitro cultures and plant regeneration in Ophiorrhiza species.)2009

    • Author(s)
      Takashi Asano, Hiroshi Sudo, Mami Yamazaki, Kazuki Saito
    • Publisher
      Humana Press-Springer
    • Related Report
      2009 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.p.chiba-u.ac.jp/lab/idenshi/index.htm

    • Related Report
      2010 Final Research Report
  • [Remarks] 「第57回日本生薬学会年会と第5回日中韓合同シンポジウムで徳島に計1200人、吉川雅之京都薬大教授が会長講演と学会賞受賞講演、斉藤和季千葉大教授が特別講演」バイオテクノロジージャパンニュース2010年9月29日

    • Related Report
      2010 Final Research Report
  • [Remarks] 斉藤和季、"植物はなぜ薬になる物質を作るのか?植物の化学的多様性のゲノム基盤解明"研究成果の見える化、千葉大学、2010.10 Ver.5,pp3(2010)

    • Related Report
      2010 Final Research Report
  • [Remarks] ネイチャージャパン特集記事「メタボロミクスで植物の成分を解明、将来の生産につなげたい」平成22年(2010年)5月

    • URL

      http://www.natureasia.com/japan/jobs/tokushu/detail.php?id=216

    • Related Report
      2010 Final Research Report
  • [Remarks] 「日本薬学会第130年会ハイライト講演注目の10題紹介有用物質生産工場としての植物細胞」科学新聞平成22年(2010年)3月26日

    • Related Report
      2010 Final Research Report
  • [Remarks] 千葉大・JSTプレスリリース「植物が自ら作る抗がん物質に対する自己耐性機構を解明-抗がん物質の効率的生産や抗がん剤耐性機構の解明に手がかり-」平成20年(2008年)4月29日。平成20年4月29日朝日新聞朝刊(全国版)「抗がん剤副作用減に光」、平成20年4月29日読売新聞朝刊(京葉版)「抗がん物質メカニズム解明」、2008年4月29日Biotechnology Japan「千葉大、JST、抗がん性アルカロイドに対する植物の自己耐性機構を解明、標的分子の変異明らかに」、2008年4月30日アサヒコム(asahi.com)「抗がん剤原料の猛毒もつ植物、なぜ平気?副作用減に道」、2008年4月30日YAHOO!ニュース「抗がん物資作る木の耐性解明=効率的生産法への応用期待-千葉大」、2008年5月16日科学新聞「千葉大植物由来の抗ガン物質自己耐性機構を解明-効果的な抗ガン剤開発に期待-」、2008年5月12日薬事日報「カンプトテシン量産と耐性克服に道千葉大グループが解明」

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.p.chiba-u.ac.jp/lab/idenshi/index.htm

    • Related Report
      2010 Annual Research Report
  • [Remarks] 千葉大・JSTプレスリリース「植物が自ら作る抗がん物質に対する自己耐性機構を解明―抗がん物質の効率的生産や抗がん剤耐性機構の解明に手がかり―」平成20年 (2008年) 4月29日。平成20年4月29日 朝日新聞朝刊 (全国版)「抗がん剤副作用減に光」、平成20年4月29日 読売新聞朝刊 (京葉版)「抗がん物質メカニズム解明」、2008年4月29日 Biotechnology Japan「千葉大、JST、抗がん性アルカロイドに対する植物の自己耐性機構を解明、標的分子の変異明らかに」、2008年4月30日 アサヒコム (asahi. com)「抗がん剤原料の猛毒もつ植物、なぜ平気? 副作用減に道」、2008年4月30日YAHOO! ニュース「抗がん物資作る木の耐性解明=効率的生産法への応用期待―千葉大」、2008年5月16日科学新聞「千葉大植物由来の抗ガン物質自己耐性機構を解明―効果的な抗ガン剤開発に期待―」、2008年5月12日 薬事日報「カンプトテシン量産と耐性克服に道 千葉大グループが解明」

    • Related Report
      2009 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.p.chiba-u.ac.jp/lab/idenshi/index.htm

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.p.chiba-u.ac.jp/lab/idenshi/index.htm

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.p.chiba-u.ac.jp/lab/idenshi/index.html

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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